Code | CSB-RA196762A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:2000 |
FC | 1:50-1:200 |
The EGR2 recombinant monoclonal antibody is synthetically generated in vitro, starting with the retrieval of EGR2 antibody genes from B cells obtained from immunoreactive rabbits. These EGR2 antibody genes are then amplified and cloned into appropriate phage vectors, which are subsequently introduced into mammalian cell lines to enable the production of functional antibodies in substantial quantities. Following this, the EGR2 recombinant monoclonal antibody is purified from the culture supernatant of the transfected cell lines through affinity chromatography. It is suitable for a range of applications, including ELISA, WB, and FC, facilitating the accurate detection of human and mouse EGR2 proteins.
EGR2 is a transcription factor that plays a central role in the development, myelination, and maintenance of the peripheral nervous system. Its functions are crucial for proper nerve function, and mutations in the EGR2 gene can lead to neurological disorders such as Charcot-Marie-Tooth disease. Additionally, EGR2 has been implicated in regulating cellular processes in cancer and nerve injury response.
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