Recombinant Human ETS translocation variant 1(ETV1)

Code CSB-YP007854HU
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Source Yeast
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Code CSB-EP007854HU
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Source E.coli
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Code CSB-EP007854HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007854HU
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Source Baculovirus
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Code CSB-MP007854HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ETV1
Uniprot No. P50549
Alternative Names DKFZp781L0674; ER81; ER81 protein; ER81; mouse; homolog of; ETS translocation variant 1; ets variant gene 1; Ets-related protein 81; Etsrp81; ETV 1; ETV1; ETV1_HUMAN; MGC104699; MGC120533; MGC120534
Species Homo sapiens (Human)
Expression Region 1-477
Target Protein Sequence MDGFYDQQVP YMVTNSQRGR NCNEKPTNVR KRKFINRDLA HDSEELFQDL SQLQETWLAE AQVPDNDEQF VPDYQAESLA FHGLPLKIKK EPHSPCSEIS SACSQEQPFK FSYGEKCLYN VSAYDQKPQV GMRPSNPPTP SSTPVSPLHH ASPNSTHTPK PDRAFPAHLP PSQSIPDSSY PMDHRFRRQL SEPCNSFPPL PTMPREGRPM YQRQMSEPNI PFPPQGFKQE YHDPVYEHNT MVGSAASQSF PPPLMIKQEP RDFAYDSEVP SCHSIYMRQE GFLAHPSRTE GCMFEKGPRQ FYDDTCVVPE KFDGDIKQEP GMYREGPTYQ RRGSLQLWQF LVALLDDPSN SHFIAWTGRG MEFKLIEPEE VARRWGIQKN RPAMNYDKLS RSLRYYYEKG IMQKVAGERY VYKFVCDPEA LFSMAFPDNQ RPLLKTDMER HINEEDTVPL SHFDESMAYM PEGGCCNPHP YNEGYVY
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
Gene References into Functions
  1. Our data indicate that miR-17-5p acts as a tumour suppressor in Triple-negative breast cancer (TNBC)by targeting ETV1, and a low-abundance of miR-17-5p may be involved in the pathogenesis of TNBC. These findings indicate that miR-17-5p may be a therapeutic target for TNBC PMID: 29126392
  2. Our results indicate that assessing AP1 and PEA3 transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3-AP1 regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 and/or ETV4 causes an OAC cell growth defect PMID: 28859074
  3. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5. PMID: 28161714
  4. the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells PMID: 28408625
  5. C646 treatment attenuated ETV1 protein expression and inactivated KIT-dependent pathways. Taken together, the present study suggests that CBP/p300 may serve as novel antineoplastic targets and that use of the selective HAT inhibitor C646 is a promising antitumor strategy for Gastrointestinal stromal tumors. PMID: 27633918
  6. these data reveal a JMJD2A/ETV1/YAP1 axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition. PMID: 26731476
  7. conclude that ETV1 is specifically expressed in the majority of gastrointestinal stromal tumors, even in some KIT-negative cases PMID: 26243012
  8. ETV1 and COP1 are a pair of independent predictors of prognosis for triple-negative breast cancer. PMID: 25884720
  9. ETV1 overexpression is associated with prostate cancer aggressiveness. PMID: 25595908
  10. Results show that ETV1 was upregulated at a higher rate in Gastrointestinal stromal tumor and was correlated with KIT expression. PMID: 24970355
  11. These results illuminate the complex interplay of AR, ETV1, and PTEN pathways in pre-cancerous neoplasia and early tumorigenesis PMID: 25631336
  12. YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts. PMID: 25479232
  13. mutation of the KIT protein that stabilizes ETV1 is likely to be a key step by which an endogenous brain-cell progenitor may form a germinoma. PMID: 25736805
  14. ETV1 expression is a rare event in human melanoma and seems to be rather based on hyperactivation of MAPK signals, by BRAF (V600E) mutation, than on ETV1 gene amplification. PMID: 25073704
  15. developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes PMID: 25203299
  16. Elevated levels of either wild-type ETV1 or its truncated derivative, dETV1, which mimics the product of an oncogenic rearrangement in certain tumors, results in increased expression of mRNA for p14ARF, a known activator of p53. PMID: 24157551
  17. These results point to a new avenue for pharmacologic ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins. PMID: 24737027
  18. The gastrointestinal stromal tumor-specific transcription factor ETV1 may have no prognostic potential, whereas its downstream gene KCTD10 is associated with a favorable prognosis. PMID: 23977394
  19. ETV1 expression is significantly correlated with Snail expression in human gastric tumor samples. In summary, we present data that ETV1 promotes Snail expression to induce EMT-like metastatic progression in gastric cancer. PMID: 24100634
  20. Non-sigma 14-3-3 proteins synergized with ETV1 to activate transcription. PMID: 23774214
  21. High ETV1 expression is associated with prostate cancer. PMID: 23076342
  22. Proprioceptive sensory neurons innervating hypaxial and axial muscles depend critically on Etv1 for survival. PMID: 23522042
  23. Our collective results identify a regulatory pathway involving ETV1, ATR, and TERT that is preferentially important for proliferation of diverse p53- cancer cells PMID: 23284306
  24. confirmed the association of an ETV1 expression signature with aggressive disease and poorer outcome in patient data PMID: 23512661
  25. Reviews evidence for a role of ETV1, 4 and 5 as oncoproteins and describe modes of their action. PMID: 22425584
  26. High ER81 expression is associated with breast cancer. PMID: 22901226
  27. Data show that MAPKAP kinase 2 overexpression is associated with expression of p38 MAP kinase and ETV1 in gastrointestinal stromal tumors (GIST). PMID: 22351694
  28. Pea3 and Erm, but not Er81, play an important role in the progression of esophageal squamous cell carcinoma PMID: 21689625
  29. The coordinate expression of Etv1 with POMC cell differentiation and its interaction with the highly cell-restricted Tpit factor indicate that Etv1 participates in a combinatorial code for pituitary cell-specific gene expression. PMID: 21622576
  30. High ER81 expression is associated with gastric adenocarcinoma. PMID: 21673681
  31. in clinical prostate cancer overexpression of full-length ETV1 is due to genomic rearrangements involving different chromosomes PMID: 21298110
  32. the ETS family member ETV1 is highly expressed in the subtypes of interstitial cells of Cajal sensitive to oncogenic KIT mediated transformation, and is required for their development PMID: 20927104
  33. Melanoma cell lines, including those with ETV1 amplification, exhibited dependency on ETV1 expression for proliferation and anchorage-independent growth. PMID: 20160028
  34. ER81 is acetylated by two coactivators/acetyltransferases, p300 and p300- and CBP-associated factor (P/CAF) . Whereas p300 acetylates two lysine residues (K33 and K116) within the ER81 N-terminal transactivation domain, P/CAF targets only K116. PMID: 12917345
  35. attenuation of transforming growth factor-beta signaling by activating Smad7 transcription may proceed not only through TGF-beta receptor-regulated Smad proteins but also an independent pathway involving transcription factor ER81 and TAK1 protein kinase PMID: 12947087
  36. transcription factor ER81 is regulated by oncogenic HER2/Neu and ACTR in mammary tumorigenesis PMID: 14747462
  37. findings show that the TMPRSS2-ERG fusion is common in prostate cancer and that the related TMPRSS2-ETV1 fusion is very rare PMID: 17390040
  38. Expression transitions from androgen-induced to androgen-independent as prostate cancer cells switch from hormone-dependent to hormone-refractory. PMID: 17505060
  39. TMPRSS2-ERV1 fusion protein was found in 1/82 prostate neoplasms. PMID: 17632455
  40. These results imply that c-Jun plays a pivotal role in the pathway that connects ligand-activated AR to elevated ETV1 expression, leading to enhanced expression of matrix metalloproteinases and prostate cancer cell invasion. PMID: 17634427
  41. Studies report a novel fusion partner for ETV1 and highlight the considerable heterogeneity of ETV1 gene rearrangements in human prostate cancer. PMID: 18594527
  42. Sox-9, ER81 and VE-cadherin have roles in retinoic acid-mediated trans-differentiation of breast cancer cells PMID: 18628953
  43. ETV1 and HER2/Neu synergized to upregulate the endogenous Rcl gene. ETV1 also bound to the Rcl promoter. PMID: 18726892
  44. 1% histologic variant of prostate carcinoma or variation morphologies demonstrated ETV! aberrations PMID: 19465903
  45. Transcriptional activation of hTERT in breast carcinomas by the Her2-ER81-related pathway. PMID: 19718948
  46. Overexpression of ETV1 is associated with tha induction of prostatic intraepithelial neoplasia. PMID: 19789348

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Involvement in disease Ewing sarcoma (ES)
Subcellular Location Nucleus.
Protein Families ETS family
Tissue Specificity Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and periphera
Database Links

HGNC: 3490

OMIM: 600541

KEGG: hsa:2115

STRING: 9606.ENSP00000385551

UniGene: Hs.22634

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