Recombinant Human Nucleotide-binding oligomerization domain-containing protein 1 (NOD1), partial

1. Two Single-Nucleotide Polymorphisms associated with susceptibility to develop dengue in NOD1 or RIPK2 genes were observed Children from Colombia. PMID: 30332343
2. our work indicates that NOD1 plays a previously undetected protective role in larval survival through CD44a-mediated activation of the PI3K-Akt signaling. PMID: 28592872
3. Upregulation of miR-495 ameliorates the high glucose-induced inflammatory, cell differentiation and extracellular matrix accumulation of human CFs by modulating both the NF-kappaB and TGF-beta1/Smad signaling pathways through downregulation of NOD1 expression. PMID: 29760746
4. Study proposes that NOD1 contributes to inflammation not only by promoting pro-inflammatory processes, but also by suppressing anti-inflammatory pathways. PMID: 28432285
5. Overexpression of either NOD1 or NOD2 reduces cell proliferation and increases clonogenic potential in vitro in breast cancer cell lines. PMID: 29615116
6. NOD1 (rs6958571) SNP was associated with gram-positive blood stream infection in Caucasian infants and extremely low birth weight infants. PMID: 28768269
7. In transgenic mice expressing human NOD1 and deficient for the murine NOD1, we showed enhanced clearance of a lipl21- mutant of Leptospira interrogans compared to the complemented strain, or to what was observed in NOD1KO mice, suggesting that LipL21 facilitates escape from immune surveillance in humans. PMID: 29211798
8. The changes in the nucleotide-binding oligomerization domain-like receptors (NLRs) in human corneas with disease expression may reflect different susceptibility to infectious and non-infectious injuries in corneas with various diseases. PMID: 26902715
9. A role for NOD1 in HCMV control via RIPK2- IKKalpha-IRF3 signaling, NOD1 polymorphisms predict the risk of infection. PMID: 27856764
10. Bronchial epithelial overexpression of TLR4 and NOD1 in severe/very severe stable COPD, associated with increased bronchial inflammation and P. aeruginosa bacterial load, may play a role in the pathogenesis of COPD PMID: 28536249
11. study provides structural and dynamic insights into the NOD1-RIP2 oligomer formation, which will be crucial in understanding the molecular basis of NOD1-mediated CARD-CARD interaction in higher and lower eukaryotes PMID: 28114344
12. Based on molecular docking studies using PG ligands, we propose few residues - G825, D826 and N850 in hNOD1-LRR and L904, G905, W931, L932 and S933 in hNOD2-LRR, evolutionarily conserved across different host species, which may play a major role in ligand recognition. PMID: 28673961
13. Nucleotide-binding oligomerization domain (NOD1) was the most significantly associated gene when analyzing exonic rare variants (RVs) in chromosome 7p to carotid bifurcation intima-media thickness (bIMT). PMID: 27936005
14. Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha. PMID: 27591899
15. the results suggest that the chronic activation of NOD1 and NOD2 receptors might play a role in the development of gastric cancer. PMID: 27917621
16. this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway. PMID: 27830463
17. Finally, NOD1 agonist increased the formation of cranial and subintestinal vessel plexus in zebrafish, and this effect was abrogated by concurrent PPARgamma activation. Overall, these findings identify a PPARgamma-miR-125a-NOD1 signaling axis in endothelial cells that is critical in the regulation of inflammation-mediated angiogenesis. PMID: 27836539
18. NOD1/2 gene variants are not linked with T2DM and IR. PMID: 27885704
19. findings show that NOD1, a PRR that normally senses bacterial peptidoglycans, is activated by HCV viral polymerase, probably through an interaction with dsRNA, suggesting that NOD1 acts as an RNA ligand recognition receptor. PMID: 27099311
20. Brain pericytes can sense Gram-negative bacterial products by both NOD1 and TLR4 receptors, acting through distinct pathways. PMID: 26915562
21. NOD1 And NOD2 polymorphisms were associated with increased susceptibility to Guillain-Barre syndrome in a Northern Indian population. PMID: 27000222
22. over-expression of NOD1 and NOD2 may be involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) Syndrome syndrome. PMID: 26980698
23. Porphyromonas gingivalis induced NOD1 overexpression in endothelial cells and that NOD1 played an important role in the process of VCAM-1 and ICAM-1 expression in endothelial cells infected with Porphyromonas gingivalis through the NF-kappaB signaling pathway. PMID: 24862550
24. contributes to fetal growth retardation and death through vascular inflammation PMID: 26880761
25. findings illuminated a role for NOD1 signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells PMID: 26759244
26. NOD1/CARD4 gene may influence the diagnosis and treatment of lung cancer PMID: 26238283
27. NOD1 and NOD2, two members of the NOD-like receptor family of pattern recognition receptors, are important mediators of ER-stress-induced inflammation in mouse and human cells PMID: 27007849
28. NOD1 signaling results in the induction of the cellular degradation pathway of autophagy and the development of pro-inflammatory responses that activate the adaptive immune system. PMID: 25801093
29. The higher NOD1 and NOD2 were observed in villi from patients who experienced recurrent spontaneous abortion compared with those who experienced a normal pregnancy. PMID: 25840495
30. Activation of the innate immune pathway via NOD1 may be partially responsible for the increased systemic inflammation and insulin resistance in metabolic syndrome. PMID: 26052894
31. NOD1 rs2709800, NOD2 rs718226, rs2111235, rs7205423 and interaction between rs718226 and H. pylori infection may be related to risk of gastric lesions. PMID: 25933107
32. We found that RNA interference-induced Caspase-12 silencing increased NOD1, hBD1 and hBD2 expression PMID: 25503380
33. Human embryonic stem cell-derived endothelial cells are TLR4 deficient but respond to bacteria via NOD1. PMID: 24690886
34. A significant association of the NOD1 +32656 GG insertion variant with protection against infection with Chlamydia trachomatis has been detected [p: 0.0057; OR: 0.52]. PMID: 25854006
35. Data indicate that E3 ligase RNF34 is associated with nucleotide-binding oligomerization domain-containing protein 1 (NOD1). PMID: 25012219
36. These findings reveal a novel pathway whereby Helicobacter pylori CagL, via interaction with host integrins, can trigger pro-inflammatory responses independently of CagA translocation or NOD1 signalling. PMID: 23107019
37. Monocyte expression and function of NOD1 and NOD2 in very preterm infants are intact and comparable/equivalent to term infants and adults. PMID: 24444388
38. Endosomal membranes are sites of NOD1/NOD2-dependent signal transduction. PMID: 24832447
39. NOD1 and RIP2 interact with bacterial peptidoglycan on endosomes to promote autophagy and inflammatory signaling. PMID: 24746552
40. the NOD1-RIP2 signaling axis is more complex than previously assumed, that simple engagement of RIP2 is insufficient to mediate signaling PMID: 24958724
41. This work reveals a role of Aggregatibacter actinomycetemcomitans outer membrane vesicles as a trigger of innate immunity via carriage of NOD1- and NOD2-active pathogen-associated molecular patterns (PAMPs). PMID: 25024364
42. NOD1 has an active role in the heightened inflammatory environment associated with both experimental murine and human diabetic cardiac disease. PMID: 24934088
43. Data indicate that the mutation of serine 7 does not affect nucleotide-binding oligomerization domain-containing protein 1 (NOD1) function. PMID: 24598002
44. NOD1 has a role in the development of insulin resistance and inflammation in pregnancies complicated by gestational diabetes mellitus. PMID: 24829218
45. The expression profile of NLRs in head and neck cancer cells differed from that seen in healthy epithelial cells. PMID: 24053487
46. NOD1 priming of human dendritic cells promoted a Th2 polarization profile that involved the production of CCL17 and CCL22 in nonallergic subjects but only CCL17 in allergic patients. PMID: 24661094
47. Helicobacter pylori cag pathogenicity island (cagPAI) involved in bacterial internalization and IL-8 induced responses via NOD1- and MyD88-dependent mechanisms in human biliary epithelial cells PMID: 24143223
48. The Nod1/2-Rip2 axis was critical to induce optimal cytokine and chemokine responses to A. baumannii infection. PMID: 24366254
49. NOD1 may have a role in mediating infection-associated inflammation PMID: 24041848
50. bacterial infection-mediated activation of NOD1,2, together with IL-32gamma, can synergize the activation of eosinophils interacting with bronchial epithelial cells. PMID: 24295830

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HGNC: 16390

OMIM: 605980

KEGG: hsa:10392

STRING: 9606.ENSP00000222823

UniGene: Hs.405153