Recombinant Human Toll/interleukin-1 receptor domain-containing adapter protein(TIRAP)

Code CSB-EP023570HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. P58753
Relevance Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Adaptor protein Wyatt MyD88 adapter-like protein
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLS
Research Area Immunology
Source E.coli
Gene Names TIRAP
Protein Names Recommended name: Toll/interleukin-1 receptor domain-containing adapter protein Short name= TIR domain-containing adapter proteinAlternative name(s): Adaptor protein Wyatt MyD88 adapter-like protein
Expression Region 1-221aa
Tag Info N-terminal GST-tagged
Mol. Weight 50.9kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Still Have Questions? Leave a Message or Start an on-line Chat
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Subcellular Location Cytoplasm, Cell membrane, Membrane
Tissue Specificity Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.
Database Links

HGNC: 17192

OMIM: 606252

KEGG: hsa:114609

STRING: 9606.ENSP00000376445

UniGene: Hs.537126

Pathway NF-kappa B signaling pathway
Toll-like receptor signaling pathway

Related Products

TIRAP Antibodies

TIRAP Antibodies for Homo sapiens (Human)

TIRAP Antibodies for Human

TIRAP Proteins

TIRAP Proteins for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.