Recombinant Human Vasopressin V1a receptor(AVPR1A),partial

Code CSB-YP002468HU
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Source Yeast
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Code CSB-EP002468HU
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Source E.coli
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Code CSB-EP002468HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002468HU
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Source Baculovirus
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Code CSB-MP002468HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names AVPR1A
Uniprot No. P37288
Alternative Names Antidiuretic hormone receptor 1a; Arginine vasopressin receptor 1A; AVPR 1; AVPR 1A; AVPR V1a; AVPR1; AVPR1A; SCCL vasopressin subtype 1a receptor; V1 vascular vasopressin receptor AVPR1A; V1a vasopressin receptor; V1aR; V1AR_HUMAN; Vascular/hepatic type arginine vasopressin receptor; Vascular/hepatic-type arginine vasopressin receptor; Vasopressin V1a receptor
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.
Gene References into Functions
  1. Study finds evidence of differential allele expression, in at least a third of human brain samples heterozygous for a reporter single nucleotide polymorphism (SNP) in the arginine vasopressin receptor 1a (AVPR1a) transcript. We also show that this functional effect and a downstream phenotype, externalizing behavior, are predicted by AVPR1a short tandem repeats but not SNPs. PMID: 29581423
  2. Despite having a similar minor allele frequency (MAF) of 14.5% compared with the SMILE cohort, our results did not support an association of the mirSNP rs11174811 with the hypertension phenotype or with continuous blood pressure outcomes in the south Indian population. PMID: 29182374
  3. The data of this study indicated that alterations in amygdala signalling may constitute a neural mechanism by which polymorphisms of the AVPR1A gene could influence ASD susceptibility. PMID: 28322981
  4. These results demonstrate that polymorphisms in the AVPR1A promoter region might be involved in pathophysiology of ASD and in functional regulation of the expression of AVPR1A. PMID: 28808521
  5. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. PMID: 27874273
  6. Three OXTR polymorphisms (rs2270465, rs2268493, rs7632287) and 2 AVPR1A polymorphisms (rs1587097, rs1042615) showed nominal effects (p < .05) on vocal symptoms, of which 1 (rs1587097) remained significant after correcting for multiple testing (p = .003). Study found potential mediation of the effect of the OXTR rs2268493 polymorphism on vocal symptoms through levels of cortisol. PMID: 28687839
  7. Using a mixed mediation and moderation model, study found that the gray matter volume of the right fusiform face area mediated the association between AVPR1A RS3 and altruistic behavior. Moreover, this mediation effect was significant only in male subjects. PMID: 27027249
  8. Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and acute-on-chronic liver failure. PMID: 28350742
  9. The gene-based analysis indicated association of variation within AVPR1A with aggressive behavior. We conclude that common variants at 2p12 show suggestive evidence for association with childhood aggression. PMID: 26087016
  10. Association between neural activation of the anterior prefrontal cortex in mothers and fathers in response to their child smiling video stimuli to induce the positive affect related to attachment with their child, and genetic variants of OT receptor (OXTR) and AVP receptor 1A (AVPR1A). PMID: 27743766
  11. Study used brainstem tissue containing this region in order to validate a reliable, pharmacologically informed receptor autoradiography protocol for use in human brain tissue more broadly and to establish where OXTR and AVPR1a are expressed in adjacent regions in the human brainstem. PMID: 26911439
  12. Mothers with long alleles for AVPR1a and DRD4 engaged in more mother-oriented social cognition, which in turn predicted less sensitive maternal behavior. There were no significant direct effects of AVPR1a or DRD4 on maternal sensitivity (beta = 0.02, P = .73 and beta = -0.10, P = .57, respectively). PMID: 27581946
  13. The arginine vasopressin receptor 1A gene (AVPR1A) is known to affect social communication and has been reported to associate with autism in several studies. PMID: 25707602
  14. examined associations between polymorphisms in OXTR and AVPR1a and individual differences in emotional and cognitive empathy 367 young adults; emotional empathy was associated solely with OXTR, whereas cognitive empathy was associated solely with AVPR1a PMID: 25476609
  15. AVPR1A RS3 was not associated with schizophrenia; variation in the AVPR1A gene contributes to social behavioral deficits associated with schizophrenia PMID: 25529259
  16. Study identified, in OXTR and AVPR1A genes, signatures of balancing selection in the cis-regulative acting sequences such as transcription factor binding and enhancer sequences, as well as in a transcriptional repressor sequence motif. Additionally, in the intron 3 of the OXTR gene, the SNP rs59190448 appears to be under positive directional selection. PMID: 25968600
  17. Haplotype analysis revealed an association of AVPR1A C*S- and C*L-haplotype (rs11174811 and RS1, respectively) and increased or decreased Extraversion (EPI) in Bashkirs, respectively. PMID: 25438555
  18. Study found that variability in the rs7298346 marker, located in the 5'-flanking region, was related to a composite measure of executive functioning in 4-year-old children after controlling for a variety of covariates and children's theory of mind. PMID: 25016245
  19. Gene-level tests showed that DRD2 was associated with vocabulary, ASPM with vocabulary and reading decoding, and AVPR1A with all three endophenotypes. PMID: 24849541
  20. humanized AVPR1A mice displayed increased reciprocal social interactions compared with wild-type animals. PMID: 24924430
  21. Early caregiving combined with genetic liability along the axis of vasopressin-oxytocin gene pathways: G x E contributions to PTSD. PMID: 24618689
  22. Men, but not women, with high levels of poststressor AVP and the 320 allele of the RS1 polymorphism reported more poststressor anger than noncarriers. PMID: 24660771
  23. There was moderate statistical evidence for interactions shoulder pain phenotypes between AVPR1A and depressive symptoms, pain catastrophizing, or kinesiophobia PMID: 24373571
  24. The results of this study found a statistically significant association between microsatellites and Korean autism spectrum disorders. PMID: 20452058
  25. Human maternal behaviour is associated with arginine vasopressin receptor 1A gene PMID: 22764113
  26. In a sample of European mothers, a microsatellite variant RS3 of the vasopressin 1a receptor gene is associated with maternal sensitivity; this association is strongest under conditions of high maternal early adversity. PMID: 22288734
  27. greater perceived threat predicted lower commitment to civic duty for individuals with one or two short alleles for AVPR1a rs1, but not for individuals with only long alleles PMID: 22457427
  28. analysis of AVPR1A and SLC6A4 polymorphisms in choral singers and non-musicians PMID: 22384070
  29. data suggest a possible interrelation between AVR and RS3 gene variants of the AVPR1A gene and impulsive aggression in patients with borderline personality disorder PMID: 22008661
  30. AVPR1A variant associated with preschoolers' lower altruistic behavior. PMID: 21980412
  31. Our results demonstrate a role for V1A-mediated signaling in the development of heart failure. PMID: 21747049
  32. report finds an association between AVPR1A and the risk for DUD. PMID: 21514569
  33. The importance of subtle, quantitative measures of endophenotype are emphasized in this review of the neural distribution of vasopressin 1a receptor (V1aR), a recent focus for studies of social behavior. PMID: 20889332
  34. A positive association between the AVPR1A haplotype (RS1 and AVR) and active current listening to music (permuted P=0.0019) was observed. PMID: 21307861
  35. Possible roles of oxytocin receptor and vasopressin-1alpha receptor in the pathomechanism of dysperistalsis and dysmenorrhea in patients with adenomyosis uteri. PMID: 20413116
  36. Evidence provided for a possible association between these SNPs and the phenotype of autism spectrum disorders. PMID: 20546835
  37. polymorphism rs1042615 of the V1a receptor altered body mass index and diastolic pressure in middle-aged and older men and the training-induced responses of DBP and low-density lipoprotein cholesterol, whereas women did not show any of these responses PMID: 20142561
  38. transmission disequilibrium testing of polymorphism in autism PMID: 12082568
  39. residue Phe225, located in transmembrane domain V, directly participates in the binding of the V1a-selective nonpeptide antagonist SR49059 PMID: 12869559
  40. In the wildtype V1aR, Arg46 constrains the inactive conformation of the receptor; on binding AVP this constraint is alleviated, promoting the transition to active V1aR PMID: 14622255
  41. examination of interaction with beta-arrestin and trafficking patterns by heterodimerization with V2 vasopressin receptor PMID: 14757828
  42. AVPR1a's exons were screened in 125 independent autistic probands. 2 promoter polymorphisms were typed in 65 autism-affected sibling-pair families. Linkage & linkage disequilibrium were seen in a subset with relatively less severe language impairment. PMID: 15098001
  43. Glu54 is critical for arginine vasopressin binding by V1aR. PMID: 15994199
  44. Association between AVPR1a and SLC6A4 reflects the social communication, courtship, and spiritual facets of the dancing phenotype. PMID: 16205790
  45. This study confirms an association between the AVPR1a gene and autism spectrum disorders and identifies a third microsatellite associated with autism spectrum disorders as well as haplotypes consisting of all three markers. PMID: 16520824
  46. analysis of a pharmacological chaperone ligand that acts on misfolded mutant V(1a) receptors PMID: 16565083
  47. These results suggest that the four SNPs in the promoter region of the V1aR gene may not be useful as genetic markers for platelet aggregation heterogeneity. PMID: 16721832
  48. There is an association of the V1aR SNP-6951 with essential hypertension in nonobese individuals. PMID: 17653244
  49. This gene contributes to social bonding in lower animals and in human behavior, suggesting a common evolutionary mechanism. PMID: 17696996
  50. study is the first to report associations between AVPR1A and OXTR genetic variation with life history traits in humans PMID: 17939166

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily
Database Links

HGNC: 895

OMIM: 600821

KEGG: hsa:552

STRING: 9606.ENSP00000299178

UniGene: Hs.2131

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