Recombinant Mouse Cyclin-dependent kinase inhibitor 1B (Cdkn1b)

1. after irradiation, loss of p27 is associated to accumulation of residual DNA damage and increased number of mitotic aberration. We show that p27 expression is necessary to preserve genomic integrity and for correct recognition and clearing-out of aberrant cells. PMID: 28377607
2. Although expressed in all retinal cell types, p27 is required to maintain the quiescence of specific cell types including bipolar cells, Muller glia, and cones while it is dispensable for preventing cell cycle reentry in other cell types PMID: 28931408
3. Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA signaling. PMID: 28506232
4. Data show that both bone marrow-derived and gastric epithelial cells contribute to the increased gastric cancer susceptibility of p27-deficient Helicobacter pylori (H. pylori) -infected mice. PMID: 27655701
5. Our results revealed that CKS1 is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability. PMID: 28365778
6. p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis. PMID: 27790794
7. p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts. PMID: 29155860
8. This study demonstrates that LMP2A uses the role of MYC in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo. PMID: 29074502
9. Our findings demonstrate a direct role for microRNAs in controlling the rate of liver regeneration after injury. PMID: 28232457
10. systems-level control of cell cycle arrest by pRB-E2F and p27-CDK regulation, is reported. PMID: 27821477
11. Results demonstrated that the addition of oncogenic mutations, such as loss of p27 or p53, promotes ovarian tumor development from the benign adenomas of germ cell-deficient ovaries. PMID: 27354067
12. p27 inactivation promotes injury islet graft loss via the elevation of proliferation and inflammatory cytokines secretion in infiltrating macrophages which induced nonspecific inflammation independent of TNF-alpha/nuclear factor-kappa b pathway. T PMID: 27631551
13. Knockout of p27 enhances arterial collateralization in response to hindlimb ischemia through enlargement of a new collateral pathway. PMID: 25701497
14. Cdkn1b exert its effects via the inhibition of proliferation and is mediated by miR-24 and targeted by the transcription factors FOXO4 and AP4 in the peroxidasin (Pxdn) mutation-induced eye disorders, such as glaucoma. PMID: 27121343
15. These results suggest that fad24 may have an important role in the S phase re-entry of quiescent C2C12 cells through the regulation of p27(Kip1) at the protein level PMID: 26902224
16. The down-regulation of p27 and the activation of mTOR pathway may be involved in miR-222-induced heart failure and autophagy inhibition. PMID: 27614440
17. Used LDLr knockout mice to identify the effects of Kiom-18 as a preliminary result in an atherosclerosis animal model; the level of p27(kip1) expression was upregulated in the presence of the Kiom-18 extract. PMID: 27465365
18. Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 gene. PMID: 26795560
19. Mice depleted for p27Kip1 in a Cdk4 R24C background develop pituitary tumors with complete penetrance and very short latencies. PMID: 26292757
20. autophagy is required for maintaining the expression level of CDKN1B in naive T cells and selectively degrades CDKN1B after TCR stimulation PMID: 26569626
21. nuclear localization sequence and C-terminus of PTHrP play a critical role in preventing skin from premature ageing that is partially mediated by p27 PMID: 26121068
22. The overexpression of p27 attenuates tumorigenicity by reducing proliferation and earlier loss of stemness of mouse induced pluripotent stem cells. PMID: 26880084
23. p27(Kip1) and p21(Cip1) are insufficient for the proliferative inhibition of smooth muscle cells cultured in type 1 collagen. honeycombs. PMID: 26522285
24. results implicate Eya4/Six1 regulates normal cardiac function via p27/casein kinase-2alpha/histone deacetylase 2 and indicate that mutations within this transcriptional complex and signaling cascade lead to the development of cardiomyopathy. PMID: 26499333
25. the p27 pathway may function downstream in the action of PTHrP to regulate skeletal growth and development. PMID: 25917430
26. Findings indicate that the Cdkn1b gene is positively regulated by a cis element at the promoter of the adjacent Lockd locus, whereas the transcribed Lockd lncRNA is dispensable for this function. PMID: 27041223
27. These results suggest that the abnormal expression of miR222 may contribute to dysregulation of the cellcycle in Alzheimer's disease, at least in part by affecting the expression of p27Kip1. PMID: 26398571
28. Data demonstrate that the deletion of cyclin-dependent kinase inhibitor p27 (p27) in parathyroid hormone like hormone (Pthrp) knock-in(KI/KI) mice can partially rescue defects in dental and mandibular development. PMID: 26859332
29. Data indicate that an AMP-ctivated kinase (AMPK)/cell-cycle inhibitor p27KIP1 (p27) axis drives activation of autophagy in rapamycin-treated tuberous sclerosis 2 protein (Tsc2)-null cells. PMID: 26975583
30. Study shows that SGK1 impairs nuclear abundance of p27 and suggests that phosphorylation of p27T197 by SGK1 is required for cardiac hypertrophy. PMID: 26344141
31. MARCKS knockdown arrested VSMC cell cycle by decreasing KIS expression. Decreased KIS expression resulted in nuclear trapping of p27kip1 in VSMCs. PMID: 26528715
32. Report defective erythropoiesis in transgenic mouse with reduced Fbxo7 expression due to decreased erythrocyte p27 expression. PMID: 26095538
33. Data (including data from studies in knockout/transgenic mice) suggest CDKN1B-RB1-E2F1 (CDKN1B-retinoblastoma 1-E2F transcription factor 1) pathway is essential for SSC (spermatogonial stem cell) self-renewal and protection against genomic damage. PMID: 25959802
34. Sphingomyelin synthase 1 regulates Neuro-2a cell proliferation and cell cycle progression through modulation of p27 expression and Akt signaling PMID: 25084761
35. identifies a regulatory axis controlling the G1/S-phase transition, relying on the regulation of MT stability by p27(kip1) and finely controlling the spatiotemporal activation of the Ras-MAPK signaling pathway PMID: 26512117
36. p27(kip1) acts as a central player of the molecular program that keeps adult hippocampal stem cells out of the cell cycle. PMID: 25185890
37. The p27(kip1) cooperates with stathmin to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression. PMID: 25486569
38. By targeting Ras/ERK pathway, p27 provided a negative control over HIF-1alpha protein synthesis in an S6-dependent manner, and abrogated arsenite-induced cell transformation via downregulation of HIF-1alpha translation. PMID: 25412313
39. P27 plays a negative regulatory role in dentin formation and alveolar bone development. PMID: 24916068
40. p27(kip1) promotes mesenchymal migration and hinders amoeboid migration upstream of the Rho/ROCK pathway. PMID: 25015295
41. Data show that phosphorylation of p27Kip1 threonine 187 (p27T187) is important in retinoblastoma protein Rb1-deficient tumorigenesis and immunity in aging. PMID: 25583987
42. Kip1 has an important role in HDAC inhibitors -mediated cell cycle arrest at G1/S but not HDAC inhibitors -induced apoptosis. PMID: 24292681
43. Data indicate that the positive rates of cyclin-dependent kinase inhibitor p27 (p27) immunocytochemical reaction were higher in the octreotide (OCT)-treated tumors. PMID: 24694834
44. These results show that p27(Kip1) actively maintains hair cells quiescence in postnatal mice PMID: 25411503
45. This study suggests that PTEN regulates p27kip1 through p-Akt, thereby regulating the proliferation and differentiation of auditory progenitors PMID: 24481416
46. involved in the chronic AMP-activated protein kinase activation that inhibits mesenchymal stem cell proliferation PMID: 24104879
47. Propose a receptor-specific function for Notch2 in regulating Jag-1-induced p27(kip1) expression and growth arrest in vascular smooth muscle cells. PMID: 23965337
48. p27 represses the proliferation of LCs, which is specifically required for maintaining the quiescent and drug-resistant states of a small subset of MA9-LSCs in collaboration with the differentiation blockage function of c-Myc. PMID: 23988911
49. Restriction of self-renewal potential to label-retaining cells is established early in life and is maintained during increased tissue turnover through the cell cycle inhibitor p27(kip1). PMID: 24715455
50. Cdkn1b overexpression in adult mice alters the balance between genome and tissue aging. PMID: 24149709

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KEGG: mmu:12576

STRING: 10090.ENSMUSP00000003115

UniGene: Mm.2958