Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 6 (Ptpn6)

1. Deletion of AT2 receptor reduced SHP-1 activity and restored VEGF actions, leading to an increased blood flow reperfusion after ischemia in diabetes mellitus. PMID: 29074590
2. These findings show a novel role for Shp-1 in the regulation of IEC growth and secretory lineage allocation, possibly via modulation of PI3K/Akt-dependent signaling pathways. PMID: 28465325
3. These findings suggest that protein tyrosine phosphatase SHP-1 may act as a positive regulator of osteoblast differentiation through direct association with and dephosphorylation of GSK3beta. PMID: 27614023
4. data establish SHP-1 as a critical player in setting the threshold downstream of TCR signaling and identify a novel function of SHP-1 as a regulator of T cell susceptibility to Treg-mediated suppression in vitro and in vivo PMID: 28550200
5. Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus PMID: 27114609
6. Our data show that SHP1 is required for the survival of mature thymocytes and the generation of the functional T-cell repertoire, as its absence leads to a reduction in the numbers of CD4(+) and CD8(+) naive T cells in the peripheral lymphoid compartments. PMID: 27354309
7. Our study suggests that metformin exerts its insulin sensitizing effects via inhibition of SHP-1 activity and expression. PMID: 28389241
8. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. PMID: 28250424
9. Studies indicate that SHP1 and SYK crosstalk as a critical regulator of MyD88 post-translational modifications and IL-1-driven inflammation. PMID: 28410990
10. Our findings uncover an important role for PP6 as an indispensable guardian of genomic integrity of the lengthy prophase I oocyte arrest, maintenance of primordial follicle pool, and thus female fertility. PMID: 27930667
11. The goal of this study was to analyze differentially expressed genes in the bone marrow of mice with NDLD to gain insight into the role of Ptpn6 in myelopoietic bone marrow pathology, and the mechanisms by which Ptpn6 insufficiency in the hematopoietic cells can lead to the development of skin lesions. PMID: 27020408
12. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'. PMID: 26878112
13. The prostate of mev/mev mice exhibits signs of aberrant differentiation and the resulting phenotype may be related to the loss of function of SHP-1. Prostatic anomalies in these mice affect, together with defects in sperm maduration, for their sterility. PMID: 24819344
14. These studies reveal critical pathways controlled by SHP-1 in oligodendrocytes that relate to susceptibility of SHP-1-deficient mice to both developmental defects in myelination and to inflammatory demyelinating diseases PMID: 25919645
15. SHP-1 regulates Cbl-b-mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination PMID: 26416283
16. The inhibitory activity of SHP-1 is needed for setting the threshold of natural killer cell reactivity. PMID: 25355530
17. Shp1 signalling is required for the establishment of a life-long protective humoral immunity. PMID: 24978161
18. Shp1 binds and controls PIPKIgamma activity and, thereby, modulates phosphatidylinositol (4,5)-bisphosphate levels and adhesion. PMID: 26101325
19. CCN1-integrin binding increased the expression of and association between SHP-1 and VEGF-R2, which leads to rapid dephosphorylation of VEGF-R2 tyrosine, thus preventing endothelial cell hyperproliferation. PMID: 26002917
20. pY motifs from known SHP-1 and SHP-2-binding proteins show that many of the pY motifs contain a hydrophobic or positively charged residue(s) at the pY+4 and pY+5 positions PMID: 16702225
21. SHP-1 appears to alter multiple aspects of macrophage biology that control virus replication, chemokine responsiveness, and inflammatory activity, that directly relate to virus-induced demyelinating disease. PMID: 19951174
22. our data reveal SHP-1 as a critical modifier of Treg function PMID: 20952680
23. these findings demonstrate that infiltrating macrophages in SHP-1-deficient mice play a crucial role in promoting viral replication and contribute to increased proinflammatory gene expression leading to demyelination. PMID: 18987138
24. there is a critical role for the tyrosine phosphatase activity of SHP-1 for induction of IL-12p40 production in macrophages in response to TLR ligands PMID: 20145200
25. In mouse liver, transcriptional activation of SHP1 gene by Prep1 attenuates insulin signal transduction and reduces glucose storage. PMID: 20864515
26. data reveal that PD-L1 is a critical modulator of Tregs' ability to suppress iALI, and this appears to involve SHP-1 activation. PMID: 25057927
27. Data indicate a pathological role for protein tyrosine phosphatase non-receptor type 6 SHP-1 in promoting inflammatory macrophage differentiation and myofiber damage in virus-infected skeletal muscle. PMID: 25681345
28. SHP-1 enzyme and Th2/Th1 paradigm may play a critical role in the maintenance of nasal immune homeostasis and in the regulation of allergic rhinitis. PMID: 25090641
29. SHP-1 contributes to nephrin deactivation in podocytes exposed to high glucose levels. PMID: 25404734
30. These results indicate that JBP regulates the expressions of SHP-1, Wnt3a, and AP-1 proteins in chemically damaged mice. PMID: 24841652
31. an SHP-1-centered feedback system wherein SHP-1 modulates CD40-induced p38MAPK activation threshold and reciprocal ERK-1/2 activation, establishing itself as a critical regulator of CD40 signaling reciprocity PMID: 25187664
32. STAT3 was a substrate for SHP-1 by co-immunoprecipitation. PMID: 24466030
33. We demonstrated that the association and oxidation of c-Src and SHP-1 by ROS are key steps in enhancing OC survival, which are responsible for increased bone loss when ovarian function ceases. PMID: 24824657
34. in DKO pre-B cells, the kinase Zap70 is associated with the pre-BCR, suggesting that Zap70 is important to promote B cell maturation in the absence of Syk and SHP-1. PMID: 24899508
35. a novel role for hepatocyte Shp1 in the regulation of PPARgamma and hepatic lipid metabolism. PMID: 24327268
36. The endothelial tyrosine phosphatase SHP-1 plays an important role for vascular hemostasis in vivo, which is crucial in TNF alpha -induced endothelial inflammation. PMID: 23766558
37. our results show for the first time that SHP-1 acts as a positive regulator of LPS-induced IL-10 production in splenic macrophages PMID: 23904162
38. Activation of Shp1-deficient CD4+ T cells results in skewing to the Th2 lineage and increased IL-4 production. PMID: 23797092
39. FGFRL1 does not function as a decoy receptor in beta-cells, but rather it enhances ERK1/2 signaling through association of SHP-1 with the receptor's intracellular SH2-binding motif. PMID: 23640895
40. Shp1 and Shp2 are major regulators of megakaryocyte development, platelet production, and function. PMID: 23509158
41. high levels of SHP-1 expression in glomeruli cause insulin resistance and podocyte loss PMID: 23531619
42. SHP-1 plays a critical role as a negative regulator in allergic inflammation, in allergen induced anaphylaxis, and seems to be required for normal basophil development. PMID: 23390550
43. Advanced glycation end product Nepsilon-carboxymethyllysine induces endothelial cell injuryinvolving SHP-1-regulated VEGFR-2 dephosphorylation. PMID: 22553146
44. dendritic cells functionally educate iNKT cells by tuning SHP-1 expression to limit reactivity. PMID: 23427253
45. Data indicate the amounts of Ptpn6 (Shp1) and MyD88 protein were reduced in dendritic cells of Ptpn6fl/flMyd88fl/flItgax-cre mice. PMID: 23521885
46. Selective target recognition of the SHP-1 knockdown natural killer (NK) cells revealed also possible involvement of the SHP-1 phosphatase in regulating other NK functions in mature NK cells. PMID: 22952938
47. findings show that most proliferating Germinal center (GC) B cells did not demonstrate active B cell receptor(BCR)signaling; signaling was limited by increased phosphatase activity; both SHP-1 and SHIP-1 were hyperphosphorylated in GC cells and remained colocalized with BCRs after ligation; SHP-1 was required for GC maintenance PMID: 22555432
48. SHP-1 is recruited early to phagosomes and that it is required for the acquisition of macrophage lysosomal features and acidification. PMID: 22826316
49. These studies suggest that abrogating SHP-1 in effector T cells may improve the efficacy of tumor elimination by T cell therapy without affecting the ability of the effector cells to persist and provide a long-term response. PMID: 22798667
50. Hyperglycemia and diabetes can cause glomerular podocyte apoptosis and endothelial dysfunction partly due to increased PKCdelta/p38 MAPK activation and the expression of SHP-1 to cause VEGF resistance, independent of NF-kappaB activation. PMID: 22499584

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KEGG: mmu:15170

STRING: 10090.ENSMUSP00000004377

UniGene: Mm.271799