B cells, also known as B lymphocytes, are pluripotent stem cells derived from bone marrow. It is an important part of adaptive immunity. When mature B cells are stimulated by antigen, they can differentiate into plasma cells, synthesize antibodies, and exert humoral immunity. In addition, B cells can also be used as antigen-presenting cells to capture antigen and present it to T lymphocytes.
The B cell antigen receptor (BCR) is a complex composed of mIg (mlgM and mlgD) and Igα/Igβ. The former recognizes the antigen and the latter transduces the antigenic stimulation signal received by the BCR. BCR directly recognizes intact, natural protein antigens, polysaccharides or lipid antigens. The cellular processes mediated by B cell antigen receptors mainly include cell proliferation and apoptosis. Its abnormality can cause a lack of humoral immune response or autoimmunity.
B cell receptor (BCR) signaling pathway is an important signaling pathway for B cell survival. B cell receptor (BCR) on the surface of B cells can recognize foreign antigen signals and mediate a series of complex biological effects, including activation, proliferation and differentiation of B cells.
Overactivation of several key kinases in the BCR signaling pathway plays an important role in the occurrence, development and drug resistance of B-cell tumors. Downstream effectors of BCR signals (e.g. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
|AKT1||AKT1 Antibody||AKT1 Protein||AKT1 ELISA Kit|
|AKT2||AKT2 Antibody||AKT2 Protein||AKT2 ELISA Kit|
|AKT3||AKT3 Antibody||AKT3 Protein||AKT3 ELISA Kit|
|BCL10||BCL10 Antibody||BCL10 Protein||BCL10 ELISA Kit|
|BLNK||BLNK Antibody||BLNK Protein||BLNK ELISA Kit|
|BTK||BTK Antibody||BTK Protein||BTK ELISA Kit|
|CARD11||CARD11 Antibody||CARD11 Protein||CARD11 ELISA Kit|
|CD19||CD19 Antibody||CD19 Protein||CD19 ELISA Kit|
|CD22||CD22 Antibody||CD22 Protein||CD22 ELISA Kit|
|CD72||CD72 Antibody||CD72 Protein||CD72 ELISA Kit|
|CD79A||CD79A Antibody||CD79A Protein||CD79A ELISA Kit|
|CD79B||CD79B Antibody||CD79B Protein||CD79B ELISA Kit|
|CD81||CD81 Antibody||CD81 Protein||CD81 ELISA Kit|
|CHUK||CHUK Antibody||CHUK Protein||CHUK ELISA Kit|
|CR2||CR2 Antibody||CR2 Protein||CR2 ELISA Kit|
|DAPP1||DAPP1 Antibody||DAPP1 Protein||DAPP1 ELISA Kit|
|F3||F3 Antibody||F3 Protein||F3 ELISA Kit|
|FCGR2B||FCGR2B Antibody||FCGR2B Protein||FCGR2B ELISA Kit|
|FOS||FOS Antibody||FOS Protein||FOS ELISA Kit|
|GRB2||GRB2 Antibody||GRB2 Protein||GRB2 ELISA Kit|