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The ADRB2 recombinant monoclonal antibody is synthesized using recombinant DNA technology and is useful in detecting human ADRB2 protein in ELISA and IHC applications. To produce this antibody, the gene responsible for the ADRB2 monoclonal antibody is first synthesized after sequencing the cDNA of the ADRB2 antibody-producing hybridomas. The hybridomas are created by fusing B cells isolated from the animal that was immunized with a synthesized peptide derived from human ADRB2 with myeloma cells. The synthesized gene is then cloned into a vector and transfected into cells for cultivation. The resulting ADRB2 recombinant monoclonal antibody is then purified through affinity chromatography from the cell culture supernatant.
The ADRB2 protein plays an important role in regulating the body's response to stress and maintaining homeostasis. It is activated by the catecholamines adrenaline and noradrenaline, which are released by the sympathetic nervous system during the "fight or flight" response. Activation of ADRB2 can lead to a number of cellular responses, including relaxation of smooth muscle in the airways, enhanced heart rate and contractility, stimulation of lipolysis, increased glucose uptake in skeletal muscle, liver, and adipose tissue, and inhibition of the release of inflammatory mediators from immune cells.
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