Recombinant Human Beta-2 adrenergic receptor(ADRB2)(G16R,E27Q)-VLPs

Code CSB-MP001392HU(M)
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Product Details

Target Names ADRB2
Uniprot No. P07550
Research Area Signal Transduction
Alternative Names ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor
Species Homo sapiens (Human)
Source Mammalian cell
Expression Region 1-413aa(G16R,E27Q)
Target Protein Sequence MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQ EKENKLLCED LPGTEDFVGH QGTVPSDNIDSQGRNCSTNDSLL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info C-terminal 10xHis-tagged
If you have specified tag type, please tell us and we will check if it’s possible to develop.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer Lyophilized from PBS, 6% Trehalose, pH 7.4
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
Datasheet & COA Please contact us to get it.

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Target Background

Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Gene References into Functions
  1. CD147 and the beta2-adrenergic receptor form hetero-oligomeric complexes. PMID: 28569760
  2. The authors suggest that increased circulating beta2-adrenergic receptor autoantibodies are associated with smoking-related emphysema. PMID: 28262783
  3. Phosphopeptide ligation onto the beta2-adrenergic receptor (beta2AR) allows stabilization of a high-affinity receptor active state by beta-arrestin1. PMID: 29581292
  4. This study provided proof that SNPs within ADRB2 is significantly associated with the susceptibility to and the prognosis of cervical vertigo, so that NPY and NA might serve as the precise diagnostic marker and treatment target of cervical vertigo. PMID: 29197114
  5. A functional SNP (rs12654778), upstream of ADRB2, was significantly associated with increased risk for COPD. PMID: 29588580
  6. Data indicate clustering of beta-2 adrenergic receptor (beta2AR) variants based on their signaling profiles. PMID: 29255305
  7. We found that polymorphic Arg16Gly in the ADRB2 gene and Ala54Thr in the FABP2 gene had a discernible effect on the renal function in Chinese type 2 DN. Our data further revealed that homozygous Gly16 allele and Thr54 allele concomitantly conferred a significantly higher risk in the eGFR reduction. PMID: 29404926
  8. decreased beta2AR functionality in patients with OA and LC was independent of patient's beta2AR genotype. PMID: 29620176
  9. there was no change in beta2-AR expression in the muscular layer of the dilated ureter PMID: 28756611
  10. Phosphorylation of the C-terminal region of ADRB2 allosterically alters the conformation around M215(5.54) and M279(6.41), located on transemembrane helices 5 and 6. PMID: 29335412
  11. Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2. PMID: 29257221
  12. In vitro studies confirmed that activation of b2AR can promote epithelial mesenchymal transition in Tongue squamous cell carcinoma (TSCC) by initiating an interleukin6/Stat3/Snail1 pathway. These results suggest that b2AR has an oncogenic role in TSCC and may be a potential therapeutic target in TSCC. PMID: 29138797
  13. Study analyzed dynamic behavior of 16 important residues in the binding pockets of beta2-adrenergic receptor bound with a variety of ligands, among which D1133.32 and N3127.39 are essential for ligand binding. The polar interactions with residues in TM5, particularly S2035.42 and S2075.46, are related to the agonistic properties, whereas hydrophobic interactions with residues in TM5 and TM6 help stabilize the receptor. PMID: 27703221
  14. SNPs at codon 16 of the ADRB2 plays a role in the oxidative metabolic demand during exercise. PMID: 29061864
  15. The presence of polymorphisms associated with the Glu27 allele and Arg16Gly and Gln27Glu genotypes had no influence on exercise-induced bronchospasm. However, the statistical trend towards greater frequency of the Gly16 allele in individuals with exercise-induced bronchospasm can be considered evidence of the influence of polymorphisms of the ADBR2 gene on EIB in adolescents. PMID: 26684442
  16. The association of Arg16 allele with the occurrence of asthma and of the Glu27 allele with overweight asthmatic adolescents evidenced the contribution of the ADBR2 gene to the development of obesity and asthma. PMID: 26409918
  17. These data highlight a novel arrestin-mediated modulation of CREB signalling, suggesting a reciprocal relationship between arrestin2 and arrestin3, wherein recruitment of arrestin3 restricts the ability of beta2AR to activate prolonged CREB phosphorylation by precluding recruitment of an arrestin2/Src/p38 complex. PMID: 28733084
  18. This systematic review and meta-analyses found that COPD risk and response to inhaled beta2-agonists were not associated with Thr164Ile, Arg16Gly, and Gln27Glu genotypes. PMID: 28506092
  19. The discovery of B2AR as a new molecular marker of obesity subphenotypes in PBMCs might contribute to clarify the adrenergic immunomodulation of inflammatory obesity. PMID: 28824322
  20. Genotypes at two variants of ADRB2 are associated with IAH. This association is comparable with the risk of classical risk factors for hypoglycemia . PMID: 28692628
  21. beta2AR signaled through Galphas and Gbetagamma subunits through a pathway that involved the tyrosine kinase SRC, the adaptor protein SHC, the guanine nucleotide exchange factor SOS, the small GTPase RAS, and the kinases RAF and MEK, which led to ERK activation PMID: 28634209
  22. these results indicate that stimulation of the beta2AR in osteoblasts triggers a Vegf-dependent neo-angiogenic switch that promotes bone vascular density and the colonization of the bone microenvironment by metastatic breast cancer cells. PMID: 28300321
  23. beta2AR is linked to transcription of alpha-synuclein and risk of Parkinson's disease in a ligand-specific fashion and constitutes a potential target for therapies. PMID: 28860381
  24. Lifetime ovulatory years were more strongly associated with ADRB2-positive ovarian tumors compared with ADRB2-negative tumors. Significant heterogeneity by ADRB2 was also observed for parity, oral contraceptive use, and age at menopause. Tumor expression of ADRB2 was not associated with ovarian cancer mortality. PMID: 27587791
  25. ADRB2 gene polymorphism is associated with bronchodilator response in chronic obstructive pulmonary disease. PMID: 28327457
  26. These data suggest that genetic variation of the ADRB2 may influence relative strength in healthy subjects and may become an important genetic determinant of muscular strength and functional capacity PMID: 28557859
  27. Findings support a supramultiplicative interaction between the Gln27Glu ADRB2 variant and socioeconomic deprivation among individuals of European descent. PMID: 27153462
  28. ADRB2 gene expressed in HIV-associated neurocognitive impairment and encephalitis chaperones OPRM1, normally located intracellularly in astrocytes, to the cell surface. PMID: 27400929
  29. X ray structure of the beta2AR bound to a polyethylene glycol-carboxylic acid derivative (Cmpd-15PA) PMID: 28813418
  30. This study demonstrates that adverse drug events induced by ritodrine are associated with ADRB2 gene polymorphisms, as well as the infusion rate of ritodrine in pregnant women with preterm labor. PMID: 29132297
  31. The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease. PMID: 27900465
  32. a substantial proportion of the beta2AR produced is non-functional and VCP plays a key role in the maturation and trafficking of the beta2AR. PMID: 27887991
  33. The protein kinase activity of PI3K phosphorylates serine residue 70 on Src to enhance its activity and induce EGFR transactivation following betaAR stimulation. PMID: 27169346
  34. The data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of chronic obstructive pulmonary disease PMID: 28093224
  35. using single-molecule fluorescence resonance energy transfer imaging, we examine TM6 movements in the beta2 adrenergic receptor (beta2AR) upon exposure to orthosteric ligands with different efficacies, in the absence and presence of the Gs heterotrimer PMID: 28607487
  36. Data show that both N6Q and N15Q mutations decreased receptor dimerization, while N187Q mutation did not influence receptor dimerization. PMID: 28467637
  37. The frequency of the genotypes and alleles of rs1042711 in ADRB2 showed a significant difference between the COPD and control groups. TT genotype and TG and TC haplotypes of rs1042711 in ADRB2 are related to pulmonary function in COPD patients. TT genotype of rs1042711 in ADRB2 and smoking amount are risk factors for COPD development. PMID: 28753063
  38. Results provide further evidence for the interaction of rs2400707, and other SNPs within the ADRB2 gene, with childhood trauma in relation to risk for posttraumatic stress disorder. PMID: 27701011
  39. Gln27Glu polymorphism of ADRB2 influences exercise-induced vascular adaptation in patients with acute coronary syndrome. PMID: 28235084
  40. B2A receptors play an important role in colorectal carcinogenesis and can be utilized as prognostic factors PMID: 28275305
  41. beta2-adrenoceptor gly16gly genotype is associated with the elevated resting cardiac output during anesthesia for abdominal aortic aneurysm surgery. PMID: 27632347
  42. Data suggest that ADRB2 (beta2 adrenergic receptor) activation (as illustrated by epinephrine and nor epinephrine) leads to robust calcium ion mobilization from intracellular stores in endoplasmic reticulum via activation of phosphoinositide phospholipase C (PLC) and opening of inositol trisphosphate receptor (IP3R). PMID: 28442571
  43. Data suggest that post-translational modifications (phosphorylation, oxidation, and nitrosylation) of RyR2 (ryanodine receptor 2) occur downstream of production of amyloid beta-peptides through ADRB2 (beta2-adrenergic receptor) Ca2+ signaling cascade that activates PKA (protein kinase A). PMID: 28476886
  44. The use of a LABA but not an LTRA as an "add-on controller" is associated with increased risk of asthma exacerbation in children carrying 1 or 2 A alleles at rs1042713. PMID: 26774659
  45. ADRB2 SNPs might be a genetic risk factor for dyslipidemia in the Chinese hypertensive patients. the A46G polymorphism was significantly associated with the elevated risk of hypertriglyceridemia. Haplotype analysis showed that the TAC haplotype carrying frequent alleles of the three SNPs played a reduced role in hypertriglyceridemia risk and the TGC haplotype carrying rare allele of A46G expressed a significant risk effe PMID: 28287890
  46. The beta2-adrenergic receptor, which induces a short cAMP response, prolongs nuclear cAMP and protein kinase A (PKA) activation by promoting endosomal cAMP production in parathyroid hormone (PTH) receptor signaling through the stimulatory action of G protein Gbetagamma subunits on adenylate cyclase type 2. PMID: 28024151
  47. beta2AR S-palmitoylated at Cys-265 are selectively preserved under a sustained adrenergic stimulation, which results in the down-regulation and degradation of betaAR. PMID: 27481942
  48. The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic. PMID: 27330078
  49. Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function. PMID: 27342779
  50. In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma. The ADRB2 genotype frequencies of the patients and control cases were found to be 10.9% (Arg16Arg), 48.8% (Arg16Gly), and 40.3% (Gly16Gly) and 24.4% (Arg16Arg), 36.2% (Arg16Gly), and 39.4% (Gly16Gly), respective PMID: 27385593

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Subcellular Location Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus.
Protein Families G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB2 sub-subfamily
Database Links

HGNC: 286

OMIM: 109690

KEGG: hsa:154

STRING: 9606.ENSP00000305372

UniGene: Hs.2551

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