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Phospho-ATF2 (T71) recombinant monoclonal antibody was prepared by cloning the coding sequence for the phospho-ERN1 (S724) monoclonal antibody (produced by immunizing animals with the synthetic phosphopeptide of ERN1) into the plasmids and transfecting the clones into cell lines. It is a rabbit IgG purified through the affinity-chromatography method. This phospho-ATF2 (T71) antibody detects endogenous levels of human ATF2only when phosphorylated at T71. It can be applied in ELISA, WB, and IF analyses.
ATF2 is found in almost all cell types and regulates the transcription of genes involved in a wide range of biological processes, including cell growth, development, and stress. ATF2 participates in the transmission of extracellular signals to the nucleus, promoting transcriptional responses to stimuli. Many stimuli, such as growth hormones, UV radiation, and cytokines, can activate ATF2. Stress-activated protein kinases (SAPKs) (e.g., p38) phosphorylate ATF2 at Thr69 and Thr71, which activates transcriptional activation of ATF2. ATF2 can interact with other AP1 proteins and translocate to the nucleus after being phosphorylated at T69/T71, allowing it to influence gene expression.
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