Code | CSB-RA007556A209phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The DNA sequence of the phospho-EIF4E (S209) monoclonal antibody was obtained by CUSABIO from splenocytes isolated from animals with human EIF4E phosphopeptide (S209) immunization. The DNA sequence was cloned into the plasmid and then transfected into cell lines for in vitro expression. The product is the phospho-EIF4E (S209) recombinant monoclonal antibody. It's an affinity-chromatography purified rabbit IgG antibody. This phospho-EIF4E (S209) antibody detects the phospho-EIF4E (S209) protein from human sources in ELISA, WB, and IHC applications.
EIF4E plays an essential role in the efficient translation of the vast majority of capped cellular mRNAs. It functions as a nucleation location for the construction of the 48S preinitiation complex by binding to the 5'-methylated guanosine cap of mRNA. EIF4E is overexpressed in numerous epithelial tumors and regulates the translation of multiple malignancy-associated mRNAs. Phosphorylation of EIF4E at serine 209 has been linked to tumor growth and decreased survival in malignant melanoma, according to Julia H Carter et al.
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