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| Code | CSB-RA007556A209phHU |
| Size | US$350 |
| Uniprot No. | P06730 |
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| Immunogen | A synthesized peptide derived from Human Phospho-EIF4E (S209) |
| Species Reactivity | Human |
| Tested Applications | ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200 |
| Relevance | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method | Affinity-chromatography |
| Isotype | Rabbit IgG |
| Clonality | Monoclonal |
| Alias | Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
| Research Area | Epigenetics and Nuclear Signaling |
| Gene Names | EIF4E |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| Involvement in disease | Autism 19 (AUTS19) |
| Subcellular Location | Cytoplasm, P-body, Cytoplasm |
| Protein Families | Eukaryotic initiation factor 4E family |
| Database Links |
HGNC: 3287 OMIM: 133440 KEGG: hsa:1977 UniGene: Hs.13211 |
| Pathway |
HIF-1 signaling pathway
mTOR signaling pathway PI3K-Akt signaling pathway Insulin signaling pathway |
EIF4E Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA007556GA01HU | EIF4E Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA935753 | Phospho-EIF4E (Ser209) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA190338 | EIF4E (Ab-209) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000519 | Phospho-EIF4E (S209) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA002308 | EIF4E Antibody | Human,Mouse,Rat,Monkey | WB,IHC,ELISA |
EIF4E Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA007556LA01HU | EIF4E Antibody | Human | ELISA, IHC, IF |
| CSB-PA007556LB01HU | EIF4E Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007556LC01HU | EIF4E Antibody, FITC conjugated | Human | ELISA |
| CSB-PA007556LD01HU | EIF4E Antibody, Biotin conjugated | Human | ELISA |
EIF4E Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP007556HU CSB-EP007556HU CSB-BP007556HU CSB-MP007556HU |
Recombinant Human Eukaryotic translation initiation factor 4E(EIF4E) | Yeast E.coli Baculovirus Mammalian cell |
2-hydroxyisobutyryl-HIST1H4A (K5) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K8) Antibody
Applications: ELISA, WB, ICC, IF
Species Reactivity: Human
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