EIF4E

EIF4E, a critical modulator of mRNA translation, is a product of eukaryotic cells. It shepherds the translation machinery to the mRNA's 5' cap, liberating the mRNA to bind ribosomes and commence protein synthesis. This protein not only governs the rate and extent of gene expression but also partakes in cellular processes such as mRNA stability, transport, and decay. Aberrations in EIF4E regulation are linked to numerous diseases, with high expression levels often correlating with tumorigenesis and drug resistance, marking EIF4E as a promising target for novel cancer therapeutics.

Validated Data

Western Blot
Positive WB detected in 293 whole cell lysate,HepG2 whole cell lysate(treated with Calyculin A or not)
All lanes Phospho-EIF4E antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 25 KDa
Observed band size: 25 KDa

IHC image of CSB-RA007556A209phHU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The following EIF4E reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

EIF4E Antibodies

EIF4E Proteins

EIF4E Antibodies

EIF4E Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007556GA01HU	EIF4E Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA935753	Phospho-EIF4E (Ser209) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA190338	EIF4E (Ab-209) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA000519	Phospho-EIF4E (S209) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA002308	EIF4E Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA007556LA01HU	EIF4E Antibody	Human	ELISA, IHC, IF
CSB-PA007556LB01HU	EIF4E Antibody, HRP conjugated	Human	ELISA
CSB-PA007556LC01HU	EIF4E Antibody, FITC conjugated	Human
CSB-PA007556LD01HU	EIF4E Antibody, Biotin conjugated	Human	ELISA
CSB-RA007556A209phHU	Phospho-EIF4E (S209) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

EIF4E Proteins

EIF4E Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP007556RB CSB-EP007556RB CSB-BP007556RB CSB-MP007556RB CSB-EP007556RB-B	Recombinant Rabbit Eukaryotic translation initiation factor 4E (EIF4E)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EIF4E Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP007556MO CSB-EP007556MO CSB-BP007556MO CSB-MP007556MO CSB-EP007556MO-B	Recombinant Mouse Eukaryotic translation initiation factor 4E (Eif4e)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EIF4E Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-EP007556HU CSB-BP007556HU CSB-MP007556HU CSB-EP007556HU-B	Recombinant Human Eukaryotic translation initiation factor 4E (EIF4E)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP007556HU	Recombinant Human Eukaryotic translation initiation factor 4E (EIF4E)	Yeast

EIF4E Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP007556XBE CSB-EP007556XBE CSB-BP007556XBE CSB-MP007556XBE CSB-EP007556XBE-B	Recombinant Xenopus laevis Eukaryotic translation initiation factor 4E (eif4e)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EIF4E Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP007556RA CSB-EP007556RA CSB-BP007556RA CSB-MP007556RA CSB-EP007556RA-B	Recombinant Rat Eukaryotic translation initiation factor 4E (Eif4e)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EIF4E Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-YP007556DKK CSB-EP007556DKK CSB-BP007556DKK CSB-MP007556DKK CSB-EP007556DKK-B	Recombinant Dictyostelium discoideum Eukaryotic translation initiation factor 4E (eif4e)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

EIF4E Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP007556BO CSB-EP007556BO CSB-BP007556BO CSB-MP007556BO CSB-EP007556BO-B	Recombinant Bovine Eukaryotic translation initiation factor 4E (EIF4E)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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EIF4E

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