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| Code | CSB-CF013563HU |
| Product Type | Transmembrane Protein |
| Size | Pls inquiry other sizes |
| Uniprot No. | P43121 |
| Storage Buffer | Tris-based buffer,50% glycerol |
| Species | Homo sapiens (Human) |
| Sequence | VPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH |
| Source | in vitro E.coli expression system |
| Gene Names | MCAM |
| Protein Names | Recommended name: Cell surface glycoprotein MUC18 Alternative name(s): Cell surface glycoprotein P1H12 Melanoma cell adhesion molecule Melanoma-associated antigen A32 Melanoma-associated antigen MUC18 S-endo 1 endothelial-associated antigen |
| Expression Region | 24-646 |
| Tag Info | 10xHis-SUMO-tag |
| Protein Description | Full Length of Mature Protein |
| Storage | Store at -20°C, for extended storage, conserve at -20°C or -80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. |
| Subcellular Location | Membrane, Single-pass type I membrane protein |
| Tissue Specificity | Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progress |
| Database Links |
HGNC: 6934 OMIM: 155735 KEGG: hsa:4162 STRING: 9606.ENSP00000264036 UniGene: Hs.599039 |
MCAM Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA013563GA01HU | MCAM Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA066991 | MCAM Antibody | Human | ELISA,WB,IHC |
| CSB-PA783399 | MCAM Antibody | Human | ELISA,WB,IHC |
| CSB-RA013563A0HU | CD146 Antibody | Human | ELISA, WB, IHC, IF, FC |
MCAM Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA10439C0Rb | MCAM Antibody, FITC conjugated | Human | ELISA |
| CSB-PA10439A0Rb | MCAM Antibody | Human | ELISA, IHC |
| CSB-PA10439D0Rb | MCAM Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA10439B0Rb | MCAM Antibody, HRP conjugated | Human | ELISA |
| CSB-MA013563A0m | CD146 Monoclonal Antibody | Human | ELISA, WB, IF, FC |
MCAM Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP013563HU CSB-EP013563HU CSB-BP013563HU CSB-MP013563HU |
Recombinant Human Cell surface glycoprotein MUC18(MCAM),partial | Yeast E.coli Baculovirus Mammalian cell |
| CSB-RP104394h | Recombinant Human Cell surface glycoprotein MUC18(MCAM),partial | E.coli |
MCAM ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E11336h | Human soluble cluster of differentiation 146,sCD146 ELISA Kit | serum, plasma, tissue homogenates | 0.31 ng/mL |
Recombinant Rat Sulfotransferase 1A1(Sult1a1)
Express system: E.coli
Species: Rattus norvegicus (Rat)
Recombinant Rabbit Integrin beta-8(ITGB8),partial,Yeast
Express system: Yeast
Species: Oryctolagus cuniculus (Rabbit)
Recombinant Human Receptor-type tyrosine-protein phosphatase zeta(PTPRZ1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Transcription initiation factor IIA subunit 2(GTF2A2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Cellular tumor antigen p53(TP53)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Plasma kallikrein(KLKB1),partial
Express system: Yeast
Species: Homo sapiens (Human)
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