Recombinant Mouse Adenosine receptor A2a (Adora2a)

1. protective role in obesity-associated nonalcoholic fatty liver disease attributable to the direct effects of A2AR on altering inflammatory and metabolic responses of macrophages and hepatocytes PMID: 29315766
2. Study demonstrates that cognitive functions, including spatial memory and mood, are impaired due to acute hypobaric hypoxia (HH); and demonstrate that genetic inactivation of A2AR prevented spatial memory impairment in acute HH model of mice. The underlying mechanism might include microglia-mediated neuroinflammation via A2AR activation in the hippocampus. PMID: 29501623
3. Cigarette smoke impairs A2A adenosine receptor mediated wound repair through up-regulation of Duox-1 expression. PMID: 28337995
4. The present study evaluates the behavioral effects of pharmacological manipulation and genetic blockade of A2A R and D2 R within the frame of such a predominant striatal heteromeric population. PMID: 29053217
5. Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors. PMID: 27312972
6. importance for MC5r and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients PMID: 27886238
7. Body weight was significantly smaller in A2AR-KO mice at the age of 6 months PMID: 29064819
8. Results show overall cognitive impairments in A2A adenosine receptor knockout mice associated with a decrease in new-born hippocampal neuron proliferation and concomitant changes in synaptic protein expression, in both the prefrontal cortex and the hippocampus. PMID: 28844595
9. aged mice have a lower ability to cope with inflammation due to C. albicans over-colonization, associated with an inability to adaptively adjust adenosine A2A receptors density PMID: 27590517
10. A2AR activation enhances its interaction with endothelial glutamate transporters. Inhibition of A2AR rescued dysfunction of brain endothelial glutamate transporters. PMID: 29526759
11. The astrocytic Lrp4 plays an important role in ischemic brain injury response. Lrp4 deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling. PMID: 29212737
12. the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH 5826 (SCH) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A(+), RORgammat(+), Foxp3(+), and IL-10(+) in CD4(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated. PMID: 28438638
13. Compared to adults, young WT mice failed to control S. pneumoniae infection after vaccination and this was associated with lower levels of CD73 on innate B cells. We hypothesized that pharmacological activation of A2a receptor may improve Pneumovax 23 immunization in young WT mice PMID: 29377929
14. Absence of A2AAR increases cochlear resistance to acoustic trauma. PMID: 28034618
15. Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder. PMID: 27133030
16. Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK/Akt/HIF-1alpha pathway. PMID: 28928465
17. it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 were mediated successively by the PGD2-DP1 receptor, adenosine-A2A receptor, and GABA-GABAA receptor systems downstream of the FPR2. PMID: 27475912
18. Study focused on the impact of A2A receptor deletion (A2A receptor knockout, A2AKO) on motivation for social exploration. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to wild type mice. PMID: 28007538
19. data showed that A2AARs control pancreatic dysfunction in HFD-induced obesity PMID: 28765173
20. Data indicate A2ARs exert minor effects in un-stressed myocardium and selectively suppress NFkappaB and JAK-STAT signalling and cardiac injury without influencing cardiac depression in endotoxemia. PMID: 27696085
21. The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings. PMID: 27339059
22. High A2aR expression is associated with Melanoma Metastasis. PMID: 28652244
23. These novel findings indicate that adenosine suppresses REM sleep via A2AR in the OB of rodents. PMID: 27485749
24. The findings suggest that disruption of the protective A2AR amplifies inflammation to accelerate glomerular damage and endogenous macrophage A2ARs are essential to protect from progressive kidney fibrosis. PMID: 27520357
25. A2A AR activation on BBB endothelial cells offers a therapeutic window that can be fine-tuned for drug delivery to the brain and has potential as a CNS drug-delivery technology. PMID: 27043281
26. this study has identified a unique role for A2aRs in regulating CD4 T cell differentiation during vaccination. PMID: 27986907
27. these observations point to a previously unappreciated role of GS protein-coupled A2aR in regulating humoral immunity, which may be pharmacologically targeted during vaccination or pathological states in which GC-derived autoantibodies contribute to the pathology. PMID: 27974461
28. In this study, we investigated whether blockade of the A2A adenosine receptor with a selective antagonist and a CD73 inhibitor may increase the efficacy of a dendritic cell-based cancer vaccine PMID: 28349824
29. Results indicate that neuroprotection by caffeine in the MPTP model of Parkinson's disease relies on the A2AR, although the specific cellular localization of these receptors remains to be determined PMID: 26905951
30. Striatopallidal adenosine A(2A) receptor signaling in the dorsomedial striatum exerts inhibitory and predominant control of goal-directed behavior by acting precisely at the time of reward. PMID: 26216520
31. Diabetes resulted in an increased A2A/A2B receptor expression in coronary arteries which resulted in enhanced A2A/A2B-mediated increase in coronary flow observed in diabetic hearts. PMID: 26654777
32. Thsi study demonstrated thata complex involvement of A2aR in the pathogenesis of chronic neuroinflammation in mice. PMID: 26920550
33. In the adenosine A2A receptor knock-out mouse, pulmonary hypertension develops through activation of RhoA/ROCK signaling pathway. PMID: 26647014
34. A2AR deletion is sufficient to prevent memory defects, hippocampal plasticity impairments as well as Tau hyperphosphorylation, in a mouse model of Alzheimer's disease PMID: 25450226
35. A2AR signaling regulates both basal and LPS-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway. PMID: 27066978
36. Plasminogen activation contributes to wound repair and suggest that adenosine A2A receptor activation promotes wound closure by a mechanism that depends on tPA. PMID: 25991438
37. These results show that the dysfunction of astrocytic A2AR, by controlling GLT-I activity, triggers an astrocyte-to-neuron wave of communication resulting in disrupted glutamate homeostasis. PMID: 25869810
38. This study showed that the recruitment of intracellular A2AR signaling in the hippocampus is sufficient to trigger memory dysfunction. PMID: 25687775
39. Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration PMID: 26964090
40. results suggest that during atherosclerosis, female mice are more susceptible to NO-dependent endothelial dysfunction and the upregulation of A2A AR may serve as a compensatory mechanism to counteract the compromised endothelial function PMID: 26201383
41. results show that A2A receptors are necessary and sufficient to trigger memory impairment. PMID: 25939452
42. A novel mutual suppression feedback loop between A2AR signaling and miR-214 in inflammation. PMID: 26171727
43. ST1535 metabolites ST3932 and ST4206 are effective adenosine A2A receptor antagonists which maybe useful in treating Parkinson disease. PMID: 25936513
44. Study shows the ability of A2AR inactivation or pharmacological blockade to control working memory deficits in the prodrome and early phases of R6/2 mice modeling Huntington's disease PMID: 25892655
45. adenosine-induced increase in coronary flow is partially mediated by Nox2-derived H2O2, which critically depends upon the presence of A2A adenosine receptors PMID: 25911169
46. Expression of NPP1 and 5'-nucleotidase by valve interstitial cells promotes the mineralization of the aortic valve through A2aR and a cAMP/PKA/CREB pathway. PMID: 25644539
47. Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses PMID: 25672397
48. These data suggest that the use of pharmacologic A2AR antagonists may hold therapeutic potential in diminishing the rate of cancer development. PMID: 26296573
49. Overall, findings from this study that implicates the contribution of EETs, PPARgamma and KATP channels downstream of A2AAR to mediate enhanced vascular relaxation in response to HS diet PMID: 25739357
50. Inhibition of small hyaluronic acid fragment activity and stimulation of A2A adenosine receptor pathway limit apoptosis and reduce cartilage damage in experimental arthritis. PMID: 25511416

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KEGG: mmu:11540

STRING: 10090.ENSMUSP00000101060

UniGene: Mm.333734