Mouse L-lactate dehydrogenase A chain(LDH-A)ELISA Kit

1. The release of lactate dehydrogenase A (LDHA) from degenerating neurons drives central nervous system (CNS) angiogenesis. PMID: 29248508
2. Hair follicle stem cells maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli mediated by LDH-A signaling. PMID: 28812580
3. Results revealed that beta-arrestin-1 regulates lactate metabolism to contribute to beta2-adrenergic receptor functions in improved memory formation. PMID: 27916196
4. The authors identified lactate dehydrogenase (LDH) as a new functional target of AMPKalpha1. PMID: 28515121
5. LDHA-associated lactic acid accumulation in melanomas inhibits tumor surveillance by T and natural killer cells. PMID: 27641098
6. lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic glycolysis but promotes IFN-gamma expression independently of its 3'UTR. PMID: 27708054
7. LDHA is a direct target of miR-34a in regulating glucose metabolism and tumor growth in breast cancer. PMID: 26902416
8. Findings suggest that RANKL protein-induced lactate dehydrogenase (LDH) activation stimulates glycolytic and mitochondrial respiratory metabolism via transcription factor NFATc1 signaling. PMID: 27077737
9. We propose a profibrotic feed forward loop, in which radiation induces LDHA expression and lactate production, which can lead to further activation of TGF-beta to drive the fibrotic process. PMID: 26254422
10. High LDH-A expression is associated with metastases in breast tumors. PMID: 23833310
11. PGC-1alpha reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PMID: 23650363
12. Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer. PMID: 23404405
13. Down-regulation of expression of stress-activated genes PKC-alpha, c-Myc and LDH-A by alpha-tocopherol in cancerous mice. PMID: 22132835
14. The cumulus cells and oocytes showed intense signals for lactate dehydrogenase (LDH)-A respectively. PMID: 21360229
15. isoproterenol induces changes in gastrocnemius muscle and serum lactate dehydrogenase expression in mice PMID: 21552790
16. Cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes. PMID: 20653129
17. The increased LDH-A/LDH-B ratio causes high brain lactate levels, which, in turn, are predictive of aging phenotypes. PMID: 21041631
18. The muscle subunit of lactate dehydrogenase is an integral part of the sarcolemmal K(ATP) channel complex in vivo, where it couples the metabolic status of the cell with the K(ATP) channel activity essential for protection against ischemia. PMID: 12145195
19. Reduction in LDH-A activity resulted in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential. The tumorigenicity of the LDH-A-deficient cells was severely diminished. PMID: 16766262
20. beta-agonists increased serum LDH levels, but it was not due to release from the heart. PMID: 17853776
21. M-LDH released from cardiomyocytes after hypoxia and reoxygenation has a role in protecting the heart from oxidative stress-induced injury through an intracellular signal transduction pathway involving ERK1/2. PMID: 18534967

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KEGG: mmu:16828

STRING: 10090.ENSMUSP00000103267

UniGene: Mm.29324