Recombinant Human Fibroblast growth factor 7 protein(FGF7) (Active)

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Code CSB-AP002421HU
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Product Details

Purity >96% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x105 IU/mg.
Target Names FGF7
Uniprot No. P21781
Research Area Cancer
Alternative Names FGF 7; FGF-7; Fgf7; FGF7_HUMAN; Fibroblast growth factor 7; HBGF 7; HBGF-7; HBGF7; Heparin binding growth factor 7; Heparin-binding growth factor 7; Keratinocyte growth factor; KGF
Species Homo sapiens (Human)
Source E.coli
Expression Region 32-194aa
Complete Sequence CNDMTPEQMA TNVNCSSPER HTRSYDYMEG GDIRVRRLFC RTQWYLRIDK RGKVKGTQEM KNNYNIMEIR TVAVGIVAIK GVESEFYLAM NKEGKLYAKK ECNEDCNFKE LILENHYNTY ASAKWTHNGG EMFVALNQKG IPVRGKKTKK EQKTAHFLPM AIT
Mol. Weight 18.9 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered 20 mM PB, 0.5 M NaCl, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Gene References into Functions
  1. Low KGF expression is associated with epithelial ovarian cancer cell proliferation and invasion. PMID: 29970688
  2. Findings suggest that excessive KGF and KGFR synthesis may contribute to the hyperproliferative state in cholesteatoma and could explain the pathological difference between cholesteatoma and CSOM. PMID: 29556625
  3. Results suggest that fibroblast growth factor 7 may stimulate endometrial stromal cells proliferation and insulin-like growth factor-binding protein 1 and prolactin expressions through ERK and JNK signal pathways in an autocrine manner. PMID: 28270036
  4. The stability and activity of rhKGF mutants were analyzed using GROMACS molecular dynamics (MD) simulations and docking tools, respectively. The results showed that N159S (N105S in rhKGF sequence) and I172V (I118V in rhKGF) substitutions caused an increased stability and affinity of the rhKGF to Fibroblast growth factor receptor 2 (FGFR2). PMID: 28093295
  5. Tregs isolated from human lung tissue can be stimulated ex vivo to induce kgf expression. PMID: 28296468
  6. FGF7 stimulation of cell invasion and migration was partially suppressed by the FGFR2 knockdown. In addition, FGF7/FGFR2 upregulated THBS1, and cell invasion and migration were decreased by knockdown of THBS1 PMID: 28339036
  7. Suppression of miR-219-5p may benefit the liver regeneration and prevent cirrhosis through increasing KGF. PMID: 27855391
  8. This study evaluated the expression of FGF7, AhR, and CYP1A1 in colorectal cancer cells and revealed a new mechanism by which KGF promotes cell proliferation through the AhR-cyclin D1 pathway in colon cancer cells. PMID: 26514676
  9. KGF expression induced epithelial cell proliferation, reaching a peak level at day 4 and then decreased later, while in the long-term model, KGF expression in the EAC led to middle ear cholesteatoma formation PMID: 25138153
  10. In the current study, conditioned media and chemically defined media with recombinant human keratinocyte growth factor (KGF) could induce hUC-MSC differentiation into sweat gland-like cells (SGCs). PMID: 26574554
  11. Coexpression of KGF and MMP-9 in gastric cancer could be a useful prognostic factor, and MMP-9 might also serve as a novel target for both prognostic prediction and therapeutics. PMID: 26350198
  12. FGF7 over expression is associated with advanced clinical features in patients with upper tract and bladder urothelial carcinoma PMID: 25623741
  13. Data indicate the key roles played, on the melanosome transfer in normal skin, by KGF/FGF7 released by dermal fibroblasts and by its receptor KGFR/FGFR2b expressed and activated on the epidermal keratinocytes. PMID: 25313018
  14. First evidence of a role of FGF7 in the regulation of sequential steps of the autophagic process and strengthen the hypothesis of a direct interplay between autophagy and differentiation. PMID: 24577098
  15. An SNP in FGF7 is associated with an increased risk of chronic obstructive pulmonary disease. PMID: 22796760
  16. These findings indicate that topically delivered KGF-1 DNA plasmid can increase epithelial thickness and strength, demonstrating the potential of this approach to restore compromised skin. PMID: 24434934
  17. Recombinant keratinocyte growth factor 1 in tobacco potentially promotes wound healing in diabetic rats. PMID: 24783215
  18. Sustained effect of KGF on cell survival and proliferation could be attributed to its ability to inhibit p53, retinoblastoma, caspases, and p27(kip) functions in apoptosis and cell cycle arrest. PMID: 24426773
  19. FGF7 stimulates osteogenic differentiation, but not proliferation, in embryonic stem cells, by activating ERK/Runx2 signaling. PMID: 24026476
  20. This paper provides an overview of the knowledge on molecular properties, biological functions and the ecent findings on clinical application of EGF7. [review] PMID: 24188496
  21. High FGF7 expression is associated with ameloblastoma. PMID: 24002438
  22. IL-19 is important for cutaneous wound healing because it upregulates KGF expression. PMID: 23582717
  23. FGF7 supports hematopoietic stem and progenitor cells and leukemia-initiating cells indirectly via FGFR2IIIb expressed on stromal cells. PMID: 24051090
  24. The aim of this study was to determine whether the K-sam gene and keratinocyte growth factor (KGF) expression may be used to identify malignant tumors with a poor prognosis. PMID: 23545898
  25. KGF could up-regulate IL-7 expression through the STAT1/IRF-1, IRF-2 signaling pathway, which is a new insight in potential effects of KGF on the intestinal mucosal immune system. PMID: 23554911
  26. The LTA downstream segment alternate core promoter was active only after specific cellular stimulation and was the major promoter used when human T cells were stimulated with TGF-beta1 and fibroblast growth factor-7. PMID: 23547113
  27. Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis. PMID: 23096718
  28. results implicate pericryptal myofibroblast-derived paracrine KGF and largely autocrine amphiregulin in the upregulation of claudin-2 in Caco-2 epithelial monolayers and consequent disruption of tight junction integrity PMID: 22946653
  29. Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. PMID: 22949940
  30. the activation of the stromal fibroblasts present in the pathological tissue, and the consequent increased secretion of KGF, play a crucial role in the deregulation of the epidermal proliferation and differentiation. PMID: 22481617
  31. these data suggest that FGF7 is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis. PMID: 22713451
  32. Repression of Ink4a in aged (ETPs) Early T-cell progenitors results in their partial rejuvenation and this can be accomplished by in vivo fibroblast growth factor 7 administration. PMID: 22555975
  33. In COPD, SNPs (rs12591300 and rs4480740) were significantly associated with COPD in an independent population (combined p values of 7.9E-7 and 2.8E-6). Increased lung tissue FGF7 expression was associated with worse measures of lung function. PMID: 21921092
  34. FGF7 enhanced keratinocyte proliferation and its expression was increased when NCTC 2544 cells were subjected to treatments with plantaricin A preparations or hyaluronic acid. PMID: 21782870
  35. Carcinoma-associated fibroblasts promotes the proliferation of a lingual carcinoma cell line by secreting keratinocyte growth factor. PMID: 21340484
  36. KGF may have a role in ameliorating radiation-induced pulmonary injury in rats PMID: 21436609
  37. These results suggest that the growth factors HGF and KGF may play a role in enhancing IL-1-stimulated production of IL-8 by epithelial cells during mucosal inflammations. PMID: 21082280
  38. KGF increases pigment production and deposition in melanocytes in vitro and in vivo PMID: 19780816
  39. The upregulation of KGF/KGFR might induce the formation of rete ridges and hyperpigmentation in solar lentigines. PMID: 20620021
  40. Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin-1alpha. PMID: 20065999
  41. the expression of keratinocyte growth factor (KGF) and keratinocyte growth factor receptor (KGFR) in Hela cells PMID: 17593825
  42. KGF and KGFR are both expressed in CaSki cells. Autocrine and recombinant human KGF affect cell proliferation and migration. PMID: 17953372
  43. keratinocyte growth factor works via an inducible lentivirus to protect bone marrow cells against bleomycin-induced pulmonary fibrosis PMID: 19956603
  44. The goal of this study was to elucidate the control mechanisms by which exogenous proteins regulate keratinocyte growth factor (KGF) expression in fibroblasts adhered to differing substrates. PMID: 20036421
  45. The effect of KGF on limbal epithelial cell growth is mediated by upregulation of DeltaNp63alpha through the p38 pathway. PMID: 19920075
  46. KGF induced proliferation but did not cause significant differentiation of 3 hematopoietic cell lines and bone marrow cells transduced with human K-sam. PMID: 11937263
  47. play important roles in lung development, lung inflammation, and repair. PMID: 11943656
  48. keratinocyte growth factor (KGF), a key stimulator of epithelial cell proliferation during wound healing, preferentially binds to collagens I, III, and VI. PMID: 11973338
  49. KGF may hold promise for the treatment of very premature neonates with bronchopulmonary dysplasia. PMID: 12016100
  50. Following activation by KGF binding, KGF and the KGF receptor remain associated in active complexes through the endocytic pathway, which is described. PMID: 12122441
  51. activity is potentiated by dermatan sulfate binding PMID: 12215437
  52. Data suggest a causal relation between telomere shortening and reduced expression of KGF and IGF-II in human fibroblasts. PMID: 12243757
  53. Increased expression of HGF and KGF by buccal mucosal fibroblasts may partly be responsible for the faster wound healing with less scar formation in the oral cavity compared with normal skin. PMID: 12413766
  54. lipopolysaccharide may induce proliferation of periodontal epithelial cells by upregulating keratinocyte growth factor 1 expression via the CD14 and Toll-like receptor signaling pathway PMID: 12438323
  55. PAK4 interacts with KGF receptor and mediate anti-apoptosis effects of KGF on epithelial cells. PMID: 12529371
  56. In the presence of keratinocytes, fibroblasts from buccal mucosa, periodontal ligament, & skin increased increased HGF and KGF production 2-3 times. This may influence the proliferation & migration of junctional epithelium and affect periodontal disease. PMID: 12645668
  57. KGF is capable of inducing human fetal beta-cell expansion. PMID: 12802496
  58. keratinocyte growth factor 1 may play a role in limiting mechanically induced apoptotic processes at the epithelial wound edge in a manner that is distinct from its proliferative function. PMID: 14962112
  59. may have an important role in cyclosporin-induced gingival overgrowth PMID: 15250830
  60. Review. The role of FGF7 in epithelial tissue repair and its therapeutic potential are discussed. PMID: 15327889
  61. FGF7 was specifically identified when selecting for in vitro phosphate transport inhibitory activity of tumor-derived cultures and was confirmed as a potent inhibitor of phosphate transport. Finally, FGF7 message was confirmed in PCR products of mRNA> PMID: 15562028
  62. Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane PMID: 15613483
  63. Results demonstrate a dysregulation of keratinocyte growth factor secretion by idiopathic pulmonary fibrosis fibroblasts; weak response to IL-1beta is associated with a defect of c-Jun expression and activation and a defect of JNK activation. PMID: 15677771
  64. in psoriatic lesions activated lymphocytes can stimulate fibroblasts to produce KGF and FGF-10, which in turn contribute to sustain the hyperproliferative status of the keratinocytes PMID: 15679583
  65. Human embryonic pancreatic mesenchyme expresses FGF7, which might be used used to expand human embryonic pancreatic epithelial cells. PMID: 15690149
  66. Expression of FGF7 in breast neoplasms may have an inhibitory role on the induction of apoptosis, possibly through the overexpression of Bcl-2. PMID: 15781986
  67. FGF& overexpression seen in advanced ovarian neoplasms; FGF7 suggested to play significant role in development of ovarian neoplasms PMID: 15809711
  68. KGF stimulated the proliferation of cyst-lining epithelial cell in vitro by regulating the expression of cyclin D1 and P21(wafl) genes. PMID: 16141466
  69. KGF requires both 1-Phosphatidylinositol 3-Kinase and JNK Mitogen Activated Protein Kinases signaling pathways to induce SREBP-1 PMID: 16162944
  70. expression of hepatocyte and keratinocyte growth factors and their receptors is preserved in patients with lung emphysema as compared to patients without emphysema PMID: 16216128
  71. KGF suppresses alpha2beta1 integrin function and promotes differentiation of the transient amplifying population in prostatic epithelium. PMID: 16554439
  72. Evaluation by immunohistochemistry of KGF receptor distribution, showed a down-modulation of this receptor, as previously reported in the presence of increased levels of KGF clear cell acanthoma (CCA). PMID: 16984257
  73. The elevated FGF7 protein levels in gastric inflammation and gastric cancer, together with the known oncogenic potential of FGF7. PMID: 17049492
  74. KGF/FGF-7 induces NF-kappaB activation and NF-kappaB plays an essential role in regulation of KGF/FGF-7-inducible gene expression and KGF/FGF-7-initiated cellular responses PMID: 17200110
  75. adenosine might stimulate hair growth through FGF-7 upregulation in dermal papilla cells PMID: 17301835
  76. Data show that enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer. PMID: 17525264
  77. KGF increased integrin alpha(5) expression by phosphorylating C/EBP-beta PMID: 17596295
  78. FGF-7 is not essential for urothelial cell proliferation in response to partial outlet obstruction; however, a significant increase in FGF-10 expression was observed in the obstructed FGF-7-null group PMID: 17609292
  79. Expression of keratinocyte growth factor was significantly increased in damaged liver tissue in correlation to the degree of fibrosis. PMID: 17692400
  80. These results indicate that KGF enhances the adhesion of colorectal cancer cells to type-IV collagen through ERK and FAK signaling pathways. PMID: 17706640
  81. High KGFR/KGF coexpression is associated with well-differentiated esophageal cancer PMID: 17786302
  82. KGF-promoted melanosome transfer was more significant in light keratinocytes compared to dark, due to an increased expression of KGF receptor in light skin keratinocytes PMID: 17882267
  83. KGFR internalization triggered by either KGF or FGF10 occurs through clathrin-coated pits PMID: 17944804
  84. PAR-1 activation strikingly induced FGF-7 production from cultured stromal cells mediated predominantly via ERK1/2 signaling pathway in benign prostatic hyperplasia PMID: 18386288
  85. In both fetuses and girls/women, the protein for KGF was detected from primordial stages in oocytes, granulosa cells (GCs) and stroma cells PMID: 19106113
  86. Over-expression of endogenous KGF genes in colorectal cancer cells increase VEGF-A production and may relate to angiogenesis in cancer. PMID: 19148469
  87. KGF may be crucial for an efficient skin photoprotection, demonstrating a direct role for KGF in the reduction of intracellular ROS content following UVB exposure. PMID: 19250802
  88. Determine pulmonary and systemic hepatocyte and keratinocyte growth factors in patients with chronic obstructive pulmonary disease. PMID: 19281086
  89. co-expression of K-sam and KGF in gastric cancer might be a useful prognostic factor. PMID: 19287982
  90. Human colon fibroblasts induce differentiation and proliferation of intestinal epithelial cells through the direct paracrine action of keratinocyte growth factor. PMID: 19326389
  91. KGF was expressed in the epithelial cells and fibroblasts of odontogenic keratocysts. The intensity of the KGF expression in the epithelial cells and the fibroblasts significantly decreased after marsupialization. PMID: 19434818
  92. Study suggests that transgenic hKGF secreted from transduced salivary glands may be useful clinically to prevent oral mucositis caused by radiation. PMID: 19584147
  93. These findings evidence KGF alveolar epithelial cell protection, enhancing effects on alveolar repair capacity, and anti-inflammatory effects in the injured neonatal lung. PMID: 19700645
  94. FGF7 protects against acute lung injury PMID: 17994369
  95. FGF7 improved survival during acute lung injury in mice PMID: 17994369

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Subcellular Location Secreted
Protein Families Heparin-binding growth factors family
Tissue Specificity Epithelial cell.
Database Links

HGNC: 3685

OMIM: 148180

KEGG: hsa:2252

STRING: 9606.ENSP00000267843

UniGene: Hs.567268

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