Code | CSB-MA025747A0m |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:1000-1:5000 |
IF | 1:50-1:200 |
After immunizing mice with recombinant human USP6 protein (348-535aa), B cells were isolated from the mouse spleen and then fused with myeloma cells to form hybridomas. USP6 antibody-producing hybridomas were selected from these hybridomas and cultured to obtain monoclonal antibodies against USP6. This USP6 monoclonal antibody is highly specific to human species and can be used in ELISA, WB, and IF applications. The antibody is purified using protein G affinity chromatography, with a purity of over 95%.
USP6 is a deubiquitinating enzyme implicated in various cellular functions, including protein degradation, DNA repair, and signal transduction. USP6 is well-known for the involvement in bone remodeling. It has been found to be overexpressed in certain types of bone tumors, such as aneurysmal bone cysts, and has been implicated in the regulation of osteoblast differentiation and bone growth. Additionally, USP6 has also been linked to the regulation of cell proliferation, migration, and invasion, and is involved in the maintenance of genomic stability.
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