ANGPTL4 Antibody

Code CSB-PA001712GA01HU
Size US$685
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Product Details

Uniprot No. Q9BY76
Target Names ANGPTL4
Alternative Names Angiopoietin like 4 antibody; Angiopoietin related protein 4 antibody; Angiopoietin-like protein 4 antibody; Angiopoietin-related protein 4 antibody; ANGL4_HUMAN antibody; ANGPT L2 antibody; ANGPT L4 antibody; ANGPTL2 antibody; Angptl4 antibody; ARP4 antibody; Fasting induced adipose factor antibody; FIAF antibody; HARP antibody; Hepatic angiopoietin related protein antibody; Hepatic fibrinogen/angiopoietin related protein antibody; Hepatic fibrinogen/angiopoietin-related protein antibody; HFARP antibody; NL2 antibody; Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody; PGAR antibody; pp1158 antibody; PPARG angiopoietin related protein antibody; PSEC0166 antibody; TGQTL antibody; UNQ171 antibody; Weakly similar to angiopoietin 1 [H.sapiens] antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Human Angptl4
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,IHC
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
Gene References into Functions
  1. Carriers of p.E40K, a variant that abolishes ANGPTL4 ability to inhibit lipoprotein lipase, have lower odds of T2D (odds ratio 0.89, 95% confidence interval 0.85-0.92, p = 6.3 x 10(-10)), lower fasting glucose, and greater insulin sensitivity. PMID: 29899519
  2. A relevant role of ANGPTL-4 in human obesity and its involvement in long-term body weight changes. PMID: 29536615
  3. Data indicate that the angiopoietin-like protein 4 (ANGPTL4)-mediated upregulation of tristetraprolin expression regulates the stability of chemokines in human colon epithelial cells. PMID: 28287161
  4. The data suggest that exercise-induced ANGPTL4 is secreted from the liver and driven by a glucagon-cAMP-PKA pathway in humans. These findings link the liver, insulin/glucagon, and lipid metabolism together. PMID: 29031727
  5. Study data support dual roles for ANGPTL4 in urothelial carcinoma progression, either as a tumor suppressor or oncogene, in response to microenvironmental context. PMID: 29035390
  6. ANGPTL4 levels are increased in both plasma and adipose tissues of subjects with hypertension. PMID: 29490644
  7. Low ANGPTL4 expression is associated with childhood obesity. PMID: 28733963
  8. SNP rs11672433, a high-frequency locus in the ANGPTL4 gene, does not influence the predisposition to brain arteriovenous malformation or its effect is too small to be detected in the present size sample set. PMID: 29221972
  9. Levels of ANGPTL4 in the circulation and HDLs were increased in type 2 diabetics altering lipid metabolism. PMID: 28645936
  10. High expression of ANGPTL4 is associated with drug resistance in prostate cancer. PMID: 28560449
  11. this study suggests that the presence of C allele of rs1044250 and G allele of rs2278236 in ANGPTL4 gene is associated with higher risk of moderate/severe proteinuria in renal transplant patients PMID: 27913276
  12. These results suggested that ANGPTL4 was essential for proliferation and metastasis of lung cancer cells. PMID: 27166634
  13. The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2 PMID: 28641978
  14. Data indicate angiopoietin-like 4 (ANGPTL4) as a key player that coordinates an increase in cellular energy flux crucial for EMT via an ANGPTL4/14-3-3gamma signaling axis. PMID: 28745316
  15. The authors now show: (1) that ANGPTL4 inactivates LPL by catalyzing the unfolding of its hydrolase domain; (2) that binding to GPIHBP1 renders LPL largely refractory to this inhibition; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 are required for this protective effect. PMID: 27929370
  16. One of the variants, rs116843064, is a damaging missense variant within the ANGPTL4 gene. PMID: 27036123
  17. reduced expression of one of the survival-associated transcripts, Angiopoietin-like 4, impairs growth of a gemcitabine-resistant pancreatic cancer cell line. PMID: 27282075
  18. Serum ANGPTL4 is elevated in coronary artery disease, but levels do not reflect severity of disease. PMID: 28795637
  19. identify ANGPTL4 as a Wnt signaling antagonist that binds to syndecans and forms a ternary complex with the Wnt co-receptor Lipoprotein receptor-related protein 6 PMID: 29017031
  20. results suggest that ANGPTL4 could contribute to the development of retinal neovascularization in sickle cell patients and could therefore be a therapeutic target for the treatment of PSR PMID: 28832635
  21. Data suggest that purified FLD (C-terminal fibrinogen-like domain) of ANGPTL4 is sufficient to stimulate lipolysis in primary adipocytes; increasing circulating FLD levels in mice not only induces white adipose tissue lipolysis in vivo but also reduces diet-induced obesity without affecting LPL (lipoprotein lipase) activity; increasing systemic FLD levels induces beige conversion in white adipose tissue. PMID: 28842503
  22. enhanced expression of angiopoietin-like 4 in rheumatoid arthritis may explain the occurrence of insulin resistance, cardiovascular risk, and joint destruction [review] PMID: 28004425
  23. Neither serum nor urine Angptl4 appear to be good biomarkers in minimal change disease. Elevated urinary Angptl4 in glomerular disease appears to reflect the degree of proteinuria rather than any specific disease. PMID: 28441404
  24. results reveal that liganded GR spatiotemporally controls ANGPTL4 transcription in a chromosomal context. PMID: 28056052
  25. analyzed samples from our previously published studies on ANGPL4 levels in patients on hemodialysis and patients with diabetes type 2. These samples did not show false positive reactions. The levels of ANGPTL4 were comparable to those detected previously PMID: 28107351
  26. Oleic acid enhances head and neck squamous cell carcinoma metastasis through the ANGPTL4/fibronectin/Rac1/Cdc42 and ANGPTL4/fibronectin/MMP-9 signaling axes. PMID: 27865799
  27. Cyclic stretching of tendon fibroblasts stimulated the expression and release of ANGPTL4 protein. PMID: 26670924
  28. ANGPTL4 is secreted by human forearm muscle in postprandial conditions after a high-saturated fatty acid meal. Plasma ANGPTL4 concentrations were not associated with in vivo skeletal muscle LPL activity after a high-saturated fatty acid meal. Dietary fat quality affects plasma ANGPTL4, but it remains to be elucidated whether this influences short-term skeletal muscle lipid handling. PMID: 27011113
  29. angiopoietin-like 4 plays an important role in the regulation of epidermal growth factor induced cancer metastasis PMID: 27797381
  30. Beyond rare-variant genetic association study determined rare hypertriglyceridemia causal ANGPTL4 variants based on high throughput sequencing. PMID: 26903168
  31. ANGPTL4 variants are associated with, not only lower fasting triglyceride levels, but also a decreased cardiovascular risk in type 2 diabetic Tunisian patients. So, T266M and E40K polymorphism predicts cardiovascular disease risk in type 2 diabetic Tunisian population. PMID: 27004807
  32. Increased ANGPTL4 expression is associated with uveal melanoma. PMID: 26761211
  33. This study showed that the tagged SNPs and high serum levels of ANGPTL4 are associated with large artery atherosclerotic stroke and the lipid characteristics. PMID: 26944173
  34. ANGPTL4 mRNA expressions and serum levels were significantly higher in high grade breast carcinoma. PMID: 26745120
  35. Knockdown of ANGPTL4 inhibits proliferation and promotes apoptosis in cervical cancer. PMID: 27053616
  36. ANGPTL4 levels were higher in both obese and non-obese PCOS patients compared to healthy controls. PMID: 26291814
  37. circulating ANGPTL4 levels are up-regulated in COPD patients, and have correlations with pulmonary function and systematic inflammation in COPD PMID: 26813452
  38. Collectively, our findings indicate that miR-134 may regulate lipid accumulation and proinfiammatory cytokine secretion in macrophages by targeting the ANGPTL4 gene. PMID: 26546816
  39. This study is the first to show that podocyte-secreted Angptl4 is upregulated in diabetic neuropathy and can be detected in urine. PMID: 25424436
  40. Data suggest that up-regulation of plasma levels of Angptl4 (angiopoietin-like 4 protein) and LPL (lipoprotein lipase) can be used as biomarkers specific to detecting the stage of diabetic cardiovascular complications. PMID: 25597500
  41. Hepatocellular carcinoma (HCC) tissues expressed significantly lower levels of ANGPTL4 mRNA than non-tumor tissues; copy number of ANGPTL4 gene in tumor tissues was significantly lower than in non-tumor tissues of HCC patients. Higher frequency of methylation of CpG sites of ANGPTL4 promoter was detected in tumor tissues compared to non-tumor tissues. PMID: 25148701
  42. results demonstrate ANGPTL4 contributes to OSCC metastasis by stimulating cell invasion. ANGPTL4 is potential therapeutic target for preventing cancer metastasis. PMID: 25060575
  43. Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers. PMID: 26933753
  44. We found that carriers of loss-of-function mutations in ANGPTL4 had triglyceride levels that were lower than those among noncarriers; these mutations were also associated with protection from coronary artery disease. PMID: 26934567
  45. ANGPTL4 might promote metastasis and might inhibit apoptosis of colorectal cancer cells by up-regulation of BMP7. PMID: 26417691
  46. A1AT binds to FA, and it is this form of A1AT that induces Angptl4 and FABP4 expression via a PPAR-dependent pathway. PMID: 26363050
  47. High serum ANGPTL4 with circulating RANKL suggests that ANGPTL4 may represent a novel marker for bone destruction in rheumatoid arthritis. PMID: 25289668
  48. results suggest targeting both ANGPTL4 and VEGF may be necessary for effective treatment or prevention of PDR and provide the foundation for studies evaluating aqueous ANGPTL4 as a biomarker to help guide individualized therapy for diabetic eye disease PMID: 26039997
  49. plasma ANGPTL4 levels as well as ANGPTL4 variants significantly predict cardiovascular events independently of conventional cardiovascular risk factors PMID: 25463098
  50. ANGPTL4 can both bind and inactivate lipoprotein lipase (LPL) complexed to GPIHBP1 and inactivation of LPL by ANGPTL4 greatly reduces the affinity of LPL for GPIHBP1 PMID: 25809481
  51. The ANGPTL4 may be a candidate target in diabetic macular edema treatment and a biomarker of ischemic-induced retinopathy, including diabetic retinopathy. PMID: 25687026
  52. Letter: Angiopoietin-like 4 is induced during sebocyte differentiation and regulates sebaceous lipogenesis in vitro but is dispensable for sebaceous gland function in vivo. PMID: 24815769
  53. The ANGPTL4 is produced by entero-endocrine cells (EEC) in human intestine and expression may be regulated by short chain fatty acids and bile acids. PMID: 24141811
  54. These studies reveal that modifying sialylation of the soluble glycoprotein angiopoietin-like 4 or changing key amino acids in its sequence can be used successfully to treat proteinuria. PMID: 24854282
  55. In high-calcified plaques, ANGPTL4 might be upregulated for antiangiogenic modulating function together with the downregulation of FGFR2, contributing to the stability of the plaques. PMID: 24075588
  56. ANGPTL4 is known to stimulate lipolysis in adults, but does not appear to mediate the increased activity in spontaneous vaginal delivery, indicating the presence of different regulatory inputs. PMID: 24324678
  57. ANGPTL4 is strongly negatively associated with low-density lipoprotein cholesterol and high-density lipoprotein cholesterol and positively with multiple features of the metabolic syndrome including triglycerides. PMID: 24626437
  58. Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. PMID: 24591600
  59. During chondrogenic differentiation of mesenchymal stem cells, angiopoietin-like 4 (ANGPTL4) triggers degradation and reduced synthesis of the cartilage matrix. PMID: 24505142
  60. ANGPTL4 upregulation may play an important role in ESCC development. PMID: 23925665
  61. Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome. PMID: 24317117
  62. A PPARbeta/delta-ANGPTL4 pathway is involved in the regulation of tumor cell invasion. PMID: 23208498
  63. Data indicate that patients with diabetic eye disease shows that HIF-1alpha and ANGPTL4 localize to ischemic Muller cells. PMID: 23959876
  64. EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas. PMID: 23617883
  65. ANGPTL4 was induced by high glucose in RPE cells and exhibited potent angiogenic activity on RE cells. PMID: 23387337
  66. Hypoxic induction of transgenic angiopoietin-like protein 4 (ANGPTL4) might modulate vascular damage, infarct size, and no-reflow PMID: 22086875
  67. Angptl4 suppresses foam cell formation to reduce atherosclerosis development. PMID: 23640487
  68. At concentrations required for PPARgamma activation and ANGPTL4 induction in colon adenocarcinoma cells. PMID: 23339868
  69. Data suggest that insulin lowers plasma ANGPTL4 levels by lowering nonesterified fatty acids and by inhibiting ANGPTL4 expression and release from liver cells; glucocorticoids counteract insulin-mediated suppression of ANGPTL4. PMID: 22972030
  70. No association was observed between polymorphisms within the HNF1-alpha and ANGPTL4 genes and the risk of acute coronary syndrome in the Czech population. PMID: 23183503
  71. Findings suggest that fatty acids (FAs)-PPARdelta/RXR-Angptl4 axis controls the lipoprotein lipase (LPL)-dependent uptake of FAs in myotubes. PMID: 23056264
  72. Data suggest that plasma ANGPTL4 level can be modulated by dietary factors; healthy subjects and patients with type 2 diabetes underwent dietary restrictions that up-regulated plasma ANGPTL4. PMID: 23283507
  73. Colorectal cancer is associated with lower preoperative plasma ANGPTL4 levels compared with benign colon disease, and the levels may vary inversely with disease severity. PMID: 22549372
  74. AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau PMID: 22729570
  75. inactivation of LPL in THP-1 macrophages primarily occurs on the cell surface where oligomers of ANGPTL4 are formed. PMID: 22820186
  76. inhibition of HIF-1 activity in BrCa cells inhibits primary tumor growth and metastasis of BrCa cells to the lungs by blocking expression of angiopoietin-like 4 (ANGPTL4) and L1 cell adhesion molecule (L1CAM);ANGPTL4 inhibits endothelial cell(EC)-EC interaction; L1CAM increases the adherence of BrCa cells to ECs PMID: 21860410
  77. Results demonstrate that HIF is sufficient to enhance osteoclast-mediated bone resorption and that ANGPTL4 can compensate for HIF-1alpha deficiency with respect to stimulation of osteoclast activity and augments osteoblast proliferation and differentiation. PMID: 20667978
  78. Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase. PMID: 22773878
  79. Studies indicate ANGPTL4 as a promising candidate for clinical intervention in the fight against cancer. PMID: 22661548
  80. Angptls would be useful in instances where there is a need to maintain HSCs ex vivo, such as during transduction for gene therapy applications PMID: 22639947
  81. overexpression of Angptl4 may promote invasion and metastasis in Colorectal cancer (CRC). PMID: 22307217
  82. Health issues associated with ANGPTL4 expression, including obesity, Type 2 diabetes, cardiovascular diseases and cancer. [Review] PMID: 22462789
  83. ANGPTL4 interacts and activates specific integrins to facilitate wound healing, modulates vascular permeability, and regulates ROS (reactive oxygen species) level to promote tumorigenesis. [Review] PMID: 22458843
  84. ANGPTL4 expression in adipose tissue to insulin was severely blunted in both type 2 diabetes mellitus and older control subjects PMID: 22078753
  85. ANGPTL4 is a target gene of HIF-1alpha and acts as an important regulator in the metastasis of hepatocellular carcinoma. PMID: 21674552
  86. Data showed that PPARbeta/delta regulates epidermal maturation via ANGPTL4-mediated signalling pathway. PMID: 21966511
  87. expression and secretion of ANGPTL4 by human adipocytes is upregulated by both hypoxia and fatty acids. The stimulatory effect of fatty acids on ANGPTL4 production is augmented under hypoxic conditions PMID: 21709421
  88. PGE(2) plays an important role in promoting cancer cell proliferation via ANGPTL4 under hypoxic conditions. PMID: 21937683
  89. Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins. PMID: 21596930
  90. the ANGPTL4 E40K and T266M variants are associated with lower triglyceride levels in the setting of type 2 diabetes PMID: 21714923
  91. Bacteria modulate FIAF expression in gut epithelial cell lines. Short chain fatty acids also stimulate FIAF expression. PMID: 21518214
  92. Angptl4 is a novel methylation-silenced gene both in rat and human mammary carcinomas. PMID: 21489049
  93. High ANGPTL4 is associated with olorectal cancer venous invasion and distant metastasis. PMID: 21308352
  94. the cleavage of ANGPTL4 by these PCs modulates its inhibitory effect on LPL activity. PMID: 21398697
  95. A synonymous SNP in ANGPTL4 and haplotypes carrying it are associated with risk of brain arteriovenous malformations (BAVM) but not with intracranial hemorrhage presentation in BAVM cases. PMID: 21212665
  96. Angptl4 mRNA expression was highly associated with ccRCC; moreover, angptl4 mRNA allows to discriminate the renal origin of metastases of clear-cell carcinomas arising from various organs PMID: 20454689
  97. Serum Angptl4 levels are significantly increased in end-stage renal disease. PMID: 20972945
  98. Data show that that elevated ANGPTL4 expression is widespread in tumors, and its suppression impairs tumor growth associated with enhanced apoptosis. PMID: 21397862
  99. Podocyte injury in minimal change disease causes increased expression and secretion of ANGPTL4 in humans. PMID: 21217681
  100. Decreased fat storage by Lactobacillus paracasei is associated with increased levels of ANGPTL4. PMID: 20927337

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Subcellular Location Secreted, Secreted, extracellular space, extracellular matrix
Tissue Specificity Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
Database Links

HGNC: 16039

OMIM: 605910

KEGG: hsa:51129

STRING: 9606.ENSP00000301455

UniGene: Hs.9613

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