CDK19 Antibody

Code CSB-PA005003GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
bA346C16.3 antibody; CDC2 related protein kinase 6 antibody; CDC2-related protein kinase 6 antibody; CDC2L6 antibody; CDK11 antibody; Cdk19 antibody; CDK19_HUMAN antibody; CDK8 like cyclin dependent kinase antibody; Cell division cycle 2 like 6 (CDK8 like) antibody; Cell division cycle 2 like protein kinase 6 antibody; Cell division cycle 2-like protein kinase 6 antibody; Cell division protein kinase 19 antibody; Cyclin dependent kinase (CDC2 like) 11 antibody; Cyclin dependent kinase 11 antibody; Cyclin dependent kinase 19 variant 2 antibody; Cyclin-dependent kinase 11 antibody; Cyclin-dependent kinase 19 antibody; Death preventing kinase antibody; Death-preventing kinase antibody; KIAA1028 antibody
Raised in
Species Reactivity
Human CDC2L6
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. Genes coregulated by CDK8/19 and NFkappaB include IL8, CXCL1, and CXCL2. PMID: 28855340
  2. Moreover, it identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer. PMID: 27678455
  3. High CDK19 expression is associated with osteosarcoma. PMID: 28416637
  4. On stimulation of TLR9, CDK8/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB and C/EBPbeta. PMID: 28151579
  5. Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog). PMID: 26002960
  6. Mediator-associated kinases CDK8 and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML) cells PMID: 26416749
  7. Microarrays identified target genes for each CDK, and we selected six genes: two target genes of CDK8, two target genes of CDK19 and two genes that were targets for both. PMID: 22117896
  8. CDK8 and CDK19, individually interact with PRMT5 and WDR77, and their interactions with PRMT5 cause transcriptional repression of C/EBPbeta target genes. PMID: 23749998
  9. plays a role in mechanisms of transcriptional regulation upon protein phosphorylation. (review) PMID: 20408451

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Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Protein Families
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Database Links

HGNC: 19338

OMIM: 614720

KEGG: hsa:23097

STRING: 9606.ENSP00000357907

UniGene: Hs.744895

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