CDK19 Antibody

Datasheet

Code	CSB-PA945984
Size	US$166
	Order now
Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA945984(CDK19 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: X200) The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA945984(CDK19 Antibody) at dilution 1/70, on the right is treated with synthetic peptide. (Original magnification: X200) Gel: 6%SDS-PAGE, Lysate: 40μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA945984(CDK19 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9BWU1

Target Names

CDK19

Alternative Names

bA346C16.3 antibody; CDC2 related protein kinase 6 antibody; CDC2-related protein kinase 6 antibody; CDC2L6 antibody; CDK11 antibody; Cdk19 antibody; CDK19_HUMAN antibody; CDK8 like cyclin dependent kinase antibody; Cell division cycle 2 like 6 (CDK8 like) antibody; Cell division cycle 2 like protein kinase 6 antibody; Cell division cycle 2-like protein kinase 6 antibody; Cell division protein kinase 19 antibody; Cyclin dependent kinase (CDC2 like) 11 antibody; Cyclin dependent kinase 11 antibody; Cyclin dependent kinase 19 variant 2 antibody; Cyclin-dependent kinase 11 antibody; Cyclin-dependent kinase 19 antibody; Death preventing kinase antibody; Death-preventing kinase antibody; KIAA1028 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human CDK19

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:10000
WB	1:500-1:2000
IHC	1:100-1:300

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Gene References into Functions

Genes coregulated by CDK8/19 and NFkappaB include IL8, CXCL1, and CXCL2. PMID: 28855340
Moreover, it identified CDK19 and CDK8 to be specifically overexpressed during prostate cancer progression, highlighting their potential as novel therapeutic targets in advanced prostate cancer. PMID: 27678455
High CDK19 expression is associated with osteosarcoma. PMID: 28416637
On stimulation of TLR9, CDK8/19 positively regulates inflammatory gene transcription in cooperation with NF-kappaB and C/EBPbeta. PMID: 28151579
Data suggest that, during neurogenesis, Mediator complex cyclin-dependent kinases (CDK8, CDK19) interact directly with PRC2 (polycomb repressive complex 2) subunit EZH2 (enhancer of zeste homolog 2), as well as SUZ12 (suppressor of zeste 12 homolog). PMID: 26002960
Mediator-associated kinases CDK8 and CDK19 restrain increased activation of key super-enhancer-associated genes in acute myeloid leukaemia (AML) cells PMID: 26416749
Microarrays identified target genes for each CDK, and we selected six genes: two target genes of CDK8, two target genes of CDK19 and two genes that were targets for both. PMID: 22117896
CDK8 and CDK19, individually interact with PRMT5 and WDR77, and their interactions with PRMT5 cause transcriptional repression of C/EBPbeta target genes. PMID: 23749998
plays a role in mechanisms of transcriptional regulation upon protein phosphorylation. (review) PMID: 20408451

Hide All

Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Nucleus.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Database Links

HGNC: 19338

OMIM: 614720

KEGG: hsa:23097

STRING: 9606.ENSP00000357907

UniGene: Hs.744895

Promotions

Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Protein Phosphorylation: The Dynamic Language of Cellular Regulation Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

Join us with

Subscribe newsletter

Leave a message

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Place an order now

I. Product details

Product name *

Code *

Size *

Quantity *

Message

II. Contact details

Name *

Email address *

Company/Organization

Phone

III. Ship To

Address *

City *

State/Province *

Zip/Post code *

Country *

Attn Name *

Phone# *

IV. Bill To Same as Shipping Address