CKS1B Antibody

Code CSB-PA596516
Size US$297Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot analysis of extracts from Jurkat cells, treated with serum (20%, 15mins), using CKS1 antibody.
  • Immunofluorescence analysis of HeLa cells, using CKS1 antibody.
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CKS1B Polyclonal antibody
Uniprot No. P61024
Target Names CKS1B
Alternative Names CDC2 associated protein CKS1 antibody; CDC28 protein kinase 1 antibody; CDC28 protein kinase 1B antibody; CDC28 protein kinase regulatory subunit 1B antibody; Cell division control protein CKS1 antibody; CKS 1 antibody; CKS-1 antibody; CKS1 antibody; CKS1_HUMAN antibody; Cks1b antibody; Ckshs1 antibody; Cyclin dependent kinases regulatory subunit 1 antibody; Cyclin-dependent kinases regulatory subunit 1 antibody; NB4 apoptosis/differentiation related protein antibody; PNAS 143 antibody; PNAS 16 antibody; PNAS 18 antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from N-terminal of Human CKS1.
Immunogen Species Homo sapiens (Human)
Clonality Polyclonal
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications ELISA,WB,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IF 1:100-1:500
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Gene References into Functions
  1. miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A. PMID: 29283424
  2. Multiple myeloma patients with CKS1B amplification are more likely to have additional high-risk cytogenetic abnormalities and a shorter PFS and OS after an auto-HCT. PMID: 27638366
  3. Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CKS1B. PMID: 27270326
  4. High CKS1B gene expression correlates with disease onset and progression of Multiple Myeloma and associated with more extra copies of 1q21. PMID: 28766538
  5. we overexpressed CKS1B in multiple cell lines and found increased sensitivity to PLK1 knockdown and PLK1 drug inhibition. Finally, combined inhibition of WEE1 and PLK1 results in less apoptosis than predicted based on an additive model of the individual inhibitors, showing an epistatic interaction and confirming a prediction of the yeast data. PMID: 27558135
  6. High expression of Cks1 was significantly associated with lymph node metastasis and survival status in nasopharyngeal carcinoma PMID: 28061788
  7. Results show that Cks1 and Cks2 promoted proliferation and prevented apoptosis of hepatocellular carcinoma HepG2 cells. PMID: 26531156
  8. Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. PMID: 24205826
  9. Regulation of Cks1 protein stability is crucially dependent on specific tyrosine and lysine residues which are potential sites for post-translational modifications. PMID: 25353373
  10. We conclude that perturbing the Hsp90 pathway could provide a useful therapeutic strategy in tumors driven by Cks1 overexpression PMID: 25544127
  11. Our results suggest a role for CKS1B in the multiple step process of progression of MGUS to MM and show that CKS1B copy gain has a more significant prognostic value than its overexpression. PMID: 24973170
  12. CKS1 mRNA and protein expression were increased in esophageal carcinoma. Overexpression of CKS1 was associated with higher grad, regional lymph node invasion, and neoplastic embolus. CKS1 was negatively associated with the p27(kip1) level in the tumor. PMID: 23301842
  13. We demonstrated that high expression of CKS1B immunostaining can be one potent prognostic factor for disease-specific survival, metastasis-free survival, and local recurrence-free survival in patients with nasopharyngeal carcinoma. PMID: 23879533
  14. Anaplastic multiple myeloma was associated with significantly higher prevalence of CKS1B amplification than non-anaplastic multiple myeloma. PMID: 24169086
  15. CKS1B analysis predicts 1q21 amplification and adverse outcome for risk stratification of patients with multiple myeloma. PMID: 20421271
  16. cyclin kinase subunit 1B nuclear expression detected by immunohistochemistry is an adverse prognostic factor for patients with multiple myeloma treated with bortezomib therapy PMID: 22047644
  17. Cks1 is overexpressed in esophageal squamous cell carcinoma tissues. Overexpression correlates with increased radiotherapy resistance of esophageal squamous cell carcinoma. PMID: 22302047
  18. Overexpression of Cks1 or Cks2 in human mammary epithelial and breast cancer-derived cells, as well as in other cell types, leads to override of the intra-S-phase checkpoint. PMID: 21697511
  19. In hepatoma cells, Cks1 controlled IL-8 expression by targeting the NF-kappaB regulator IkappaBalpha, which led to NF-kappaB activation, via a p27-independent regulation of IkappaB kinase complex components. PMID: 21917729
  20. Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance. PMID: 20930946
  21. A significant CKS1B overexpression was observed in oral squamous cell carcinoma and lymph node metastases samples than in oral lichen planus or oral leukoplakia. PMID: 21117028
  22. Association between CKS1B protein overexpression and both polysomy and amplification was demonstrated in cutaneous squamous cell carcinoma PMID: 20737481
  23. CKS-1B is commonly expressed in mantle cell lymphoma, particularly in aggressive histologic variants, and may be involved in pathogenesis. PMID: 20688354
  24. CKS1B overexpression implicates clinical aggressiveness of hepatocellular carcinomas but not p27(Kip1) protein turnover. PMID: 19866239
  25. Overexpression of Cks1 and Cks2 is associated with the aggressive tumour behaviours of hepatocellular carcinoma. PMID: 19845855
  26. Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family. PMID: 12473461
  27. induction of Skp2 and Cks1 degradation in G1 represents a principal mechanism by which APC/C(Cdh1) prevents the unscheduled degradation of SCF(Skp2-Cks1) substrates and maintains the G1 state PMID: 15014502
  28. Cks1 overexpression may play an important role for oral squamous cell carcinoma development through Skp2-mediated p27 degradation PMID: 15579456
  29. analysis of the protein dynamics of Cks1 PMID: 15772084
  30. ubiquitin ligase subunit Cks1 is involved in p27Kip1 down-regulation and may have an important role in the development of aggressive tumor behavior in breast cancer. PMID: 16168119
  31. over-expression of CKS1B, mainly due to gene amplification, imparts a poor prognosis in MM, possibly as a result of enhanced degradation of p27Kip1. PMID: 16188652
  32. Cks1 expression level regulates melanoma cell growth, most likely through effects on cell proliferation. PMID: 16924241
  33. Results show that complex formation between Cks1 and Skp2 causes conformational changes in both proteins in regions distant from the respective binding sites. PMID: 16979657
  34. Generally, the observation that the potential oncogene Cks1 is downregulated by the tumor suppressor p53 corresponds well with the idea that p53 employs multiple ways in order to halt the cell cycle. PMID: 17377499
  35. Cks1 expression was only correlated with tumor size in renal cell carcinoma. PMID: 18922157
  36. These data suggest that Cks1 is an oncogene in the 1q21 amplicon and plays an important role for breast cancer development. PMID: 19161979

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Protein Families CKS family
Database Links

HGNC: 19083

OMIM: 116900

KEGG: hsa:1163

STRING: 9606.ENSP00000471505

UniGene: Hs.374378

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