DRD1 Antibody

Datasheet
Code CSB-PA007178GA01HU
Size US$685
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Product Details

Uniprot No. P21728
Target Names DRD1
Alternative Names D(1A) dopamine receptor antibody; D1A dopamine receptor antibody; DADR antibody; Dopamine D1 receptor antibody; dopamine receptor D1 antibody; DR D1 antibody; DR D1A antibody; DRD 1 antibody; DRD 1A antibody; DRD1 antibody; DRD1_HUMAN antibody; DRD1A antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human DRD1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Gene References into Functions
  1. activation of the dopamine D1 receptor on human airway epithelium could induce mucus overproduction, which could worsen airway obstructive symptoms. PMID: 29606146
  2. The promoter region of DRD1 corresponded to positions - 1250 to + 250 in the DNA sequence. The transcription factor-binding sequence was localized. PMID: 30022436
  3. Greater DRD1-related coexpression was associated with lower prefrontal activity and higher working memory performance, indicating greater working memory efficiency. PMID: 29735686
  4. Molecular dynamics simulations show that the interaction of dopamine with the D1 receptor leads to the formation of a hydrogen-bond network with its catechol group and helices 3, 5, and 6, including water molecules. The para hydroxyl group of dopamine binds directly to S5.42 and N6.55, the latter also interacting with S5.43. The formation of this hydrogen-bond network, triggers the opening of the E6.30-R3.60 ionic lock. PMID: 28361444
  5. Two SUMO modification sites existed in dopamine receptor D1, the phosphorylation of which, due to SUMO modification, can interact with PP2A, leading to the inhibition of D1 de-phosphorylation and normal function. PMID: 28770955
  6. Nucleus accumbens dopamine-dopamine receptor signaling regulates sexual preference for females in male mice via Trpc2. PMID: 29241537
  7. Positron emission tomography data showed strong to moderate evidence in favor of failed replications of correlations between D1-R availability and trait social desirability or physical aggression. PMID: 29543812
  8. DR1 induces osteosarcoma cell apoptosis via changes to the MAPK pathway PMID: 28699280
  9. Synonymous SNPs (rs1799914 and rs4867798) of the DRD1 gene were associated with Essential Hypertension in Hani nationality However, none SNPs of DRD1 and DRD3 of best models showed association with Essential Hypertension in Han and Yi nationality. PMID: 28579604
  10. study to identify putative genetic factors in genes of serotonergic and dopaminergic systems modulating the level of manifestation of depressive symptoms in children; a significant interaction effect was detected between rs1039089 in conjunction with rs877138 located upstream of DRD1 and DRD2 genes respectively PMID: 27472173
  11. D1 receptor system is associated with pre-motor inhibition electrophysiological correlates of response inhibition processes PMID: 27021648
  12. DRD1, DRD2 and DRD3 may not be the susceptibility genes for schizophrenia in the Chinese Han population. PMID: 27591410
  13. the D1 receptor exists in several different membrane localizations, depending on the receptor's conformation. PMID: 27570114
  14. D1 receptor is involved in mediating the epileptic effects of Abeta1-42. PMID: 27701029
  15. Signaling of dopamine receptor D1 is regulated by VPS35. PMID: 27460146
  16. The Parkinson's disease-associated LRRK2 mutant G2019S impairs DRD1 internalization, leading to an alteration in signal transduction. The mutant forms of LRRK2 also affect receptor turnover by decreasing the rate of DRD2 trafficking from the Golgi complex to the cell membrane. PMID: 28582422
  17. Here, using PET with [(11)C]raclopride, we identified in the AKT1 gene a new variable number tandem repeat (VNTR) marker associated with baseline striatal dopamine D2/D3 receptor availability and with methylphenidate-induced striatal dopamine increases in healthy volunteers. PMID: 28416594
  18. We explore the role of mothers' executive function in mediating the relation between oxytocin and dopamine gene variants and maternal responsiveness and examined single nucleotide polymorphisms (SNPs) related to the dopamine system DRD1 rs686, DRD1 rs265976,. Dopamine SNPs were not associated with any measure of executive function or parenting (all P > 0.05). PMID: 27620964
  19. DRD1 gene polymorphisms are related to heroin dependence in a Chinese Han population and may be informative for future genetic or biological studies on heroin dependence. PMID: 25966176
  20. Polymorphic mutations in the D2 receptor play a role in dimmer formation with the dopamine D1 receptor. PMID: 28119185
  21. Parkinson's patients carrying allele T at DRD1C62T had an increased risk of visual hallucinations (VHs), expressed as OR (95 % CI, p value), of 10.7 (2.9-40, p = 0.0001). Moreover, patients with DRD1-48 GG and 62TT genotype displayed shorter time to VHs, whereas a longer time to VHs was found in subjects carrying the DRD4 CG alleles PMID: 27497990
  22. DRD1 gene expression reduction in breast cancer patients after spiritual intervention PMID: 26597879
  23. The results of this study showed that Lack of Association Between Polymorphisms in Dopamine Receptor-1 Genes With Childhood Autism in Chinese Han Population. PMID: 26337060
  24. In the dominant model, rs4532 locus of DRD1 gene was related to hypertension with a pooled OR of 1.353 (95% CI =1.016-1.802, P=0.038). [meta-analysis] PMID: 26730182
  25. This study revealed that the factors of schizotypy resembling the negative symptoms of schizophrenia are associated with the minor rs4532/C allele of 4532 SNP on the DRD1 gene. PMID: 26723139
  26. on a sequence learning task in 161 Caucasian participants, the DRD1 polymorphism predicted the ability to learn new sequences PMID: 26419600
  27. the DRD1 gene is implicated in the pathophysiology of psychosis and support the dopamine hypothesis of schizophrenia. PMID: 26957229
  28. No significant association between candidate gene variants and criminal behavior was detected. PMID: 26041607
  29. In penetrating brain injury, carriers of more transcriptionally active DRD1 alleles compared demonstrated greater aggression levels due to medial prefrontal cortex lesions but reduced aggression levels due to lateral prefrontal cortex lesions. PMID: 24618367
  30. Conserved residues in intracellular loop 1 and transmembrane region 2 of DRD1 and DRD5 are essential in ligand binding and signal transduction. PMID: 26186971
  31. D1R and D5R colocalize in renal proximal tubule cells and physically interact in second messenger coupling pathways and heterologous receptor interaction between the two receptors. PMID: 24552847
  32. Dopamine D1 receptor (DRD1) 5' region haplotypes significantly affect transcriptional activity in vitro PMID: 26484506
  33. Polymorphisms in DRD1, DRD2 and GRIN2B confer increased risk of impulse control problems among PD patients. PMID: 25896831
  34. Stress, which in part is mediated by dopamine acting via the D1 receptor, may disrupt normal synaptic plasticity in adolescence resulting in excessive synaptic elimination PMID: 24410560
  35. Dopamine D1 receptor-expressing neurons provide the dominant source of accumbal inhibition to lateral hypothalamus to control over feeding. PMID: 26593092
  36. The observed frequency of dopamine DRD1 and DRD4 polymorphisms is similar to the distribution of these variants in other Caucasian populations PMID: 26665568
  37. D1-like receptors inhibit ROS production by altering PON2 distribution in membrane microdomains in the short-term, and by increasing PON2 expression in the long-term. PMID: 25740199
  38. did not find significant pooled Odds Ratios for any of the six genes, under different models and stratifying for ethnicity. PMID: 25660313
  39. Results suggest that altered splicing of DRD2 and expression of DRD1 may constitute a pathophysiological mechanism in risk for schizophrenia, bipolar and major depressive disorders PMID: 24322206
  40. The GG genotype of rs4532 locus in DRD1 gene was associated with an increased risk of bipolar disorder (Meta-analysis). PMID: 24001587
  41. this work suggests that D1 receptor alters the distribution of Galphas and Galphai3 subunits inside the membrane. PMID: 25527226
  42. Sorting nexin 5 and dopamine d1 receptor regulate the expression of the insulin receptor in human renal proximal tubule cells PMID: 25825816
  43. dopamine receptor is involved in the etiological and cognitive deficits of BD. DRD4 may associate with psychotic symptomatology rather than with a unique diagnosis of BD. DRD1 may associate with cognitive deficits of BD. PMID: 25233244
  44. DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood. PMID: 25281486
  45. DRD1 polymorphisms may not influence the clinical efficacy of risperidone in Chinese schizophrenia patients. PMID: 25179995
  46. Dopamine D1 receptor activation increases HIV entry into primary human macrophages. PMID: 25268786
  47. LRs are essential not only for the proper membrane distribution and maintenance of AC5/6 activity but also for the regulation of D1R- and D5R-mediated AC signaling. PMID: 25049074
  48. Two rare missense variants in DRD1 were found in patients with tardive-like dystonia. PMID: 24768614
  49. DRD1 might contribute minimally to the emergence of symptoms and cognitive difficulties associated with ADHD in childhood, but may act as a modifier gene of these clinical features and outcome during later development for those with ADHD PMID: 24410775
  50. Constitutive D1R differs from D5R in that it fails to drive expression CRE-regulated genes. Treatment of a D1R line with cis-flupentixol induced up-regulation of Na,K-ATPase-alpha2, NHE-2 and NHE-3 mRNA levels. PMID: 25154512
  51. Nicotinic AChRs 4 and 7 as well as dopaminergic receptors D1 and D2 were also increased in males and females with AD. PMID: 24292102
  52. The polymorphisms in the DRD1 and DRD4 may influence susceptibility to alcohol addiction in the subjects of north Indian origin. PMID: 24135011
  53. The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. PMID: 24004608
  54. This study suggests a possible effect of the DRD1 rs4532 polymorphism on the dopaminergic modulation of task goal activation processes during action cascading PMID: 24719111
  55. The results indicated that DRD1 gene polymorphism may not play an important role in the susceptibility of heroin dependence in the Chinese Han population, but it may be associated with the rapidity of heroin dependence development from first drug use. PMID: 23661099
  56. LRRK2 affects the levels of dopamine receptor D1 on the membrane surface in neuronal cells PMID: 24167564
  57. Dopamine D1 receptor expression in spiny medium neurons of dorsal striatum differs from dopamine D2 receptor expression. PMID: 23908605
  58. HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations. PMID: 24078558
  59. DRD1 rs686 minor allele decreases the opioid dependence risk by prolonging the transition to dependence and attenuating opioid-induced pleasure in the Chinese. PMID: 23976958
  60. These data extend findings of dose-dependent inverted U-shaped effects of D1 receptor activation on neuroplasticity of the motor cortex. PMID: 24523562
  61. D1 allelic status (rs4532) predicts side-effects from stimulant medication for attention-deficit/ hyperactivity disorder PMID: 23952191
  62. we show that SULT1A3 and a closely related protein SULT1A1 are highly inducible by dopamine. This involves activation of the D1 and NMDA receptors. Both ERK1/2 phosphorylation and calcineurin activation are required for induction. PMID: 24136195
  63. The mechanism of D(1)R/D(2)R-mediated calcium signaling involves more than receptor-mediated G(q) protein activation. PMID: 23680635
  64. D1R and AT1R are functional in HK2 cells, enabling Gq-mediated downstream signaling in a Gi dependent manner PMID: 23698121
  65. Its signaling regulates human osteoclastogenesis. (review) PMID: 23445730
  66. through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7 PMID: 23842570
  67. Blockade of dopamine D1 receptors reduces the number of dendritic spines in dopaminergic neuron cultures. PMID: 23231809
  68. study investigated the relationship of dopamine D(1) receptor expression between striatal subdivisions and extrastriatal regions in using positron emission tomography PMID: 23185434
  69. internalization of agonist-activated D1R is regulated by both SNX5 and GRK4, and that SNX5 is critical to the recycling of the receptor to the plasma membrane PMID: 23195037
  70. Two DRD1 single-nucleotide polymorphisms (SNPs rs265981 and rs686) significantly associate with maternal orienting away from the infant, as do DRD1 haplotypes. PMID: 22574669
  71. analysis of Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain PMID: 23185343
  72. The DRD1 rs4532 polymorphism showed a dose-response gradient with increased risk for treatment resistance and may be a potential pharmacogenetic marker for antipsychotic drug treatment response. PMID: 23036699
  73. Upregulation of D1 receptors in schizophrenia is related to the illness itself. PMID: 21768159
  74. Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. PMID: 22710646
  75. investigated whether selected polymorphisms in the dopamine receptors genes (DRD1, DRD2, DRD3, and DRD4) are associated with pathologic in Korean population; no associations were seen PMID: 21853233
  76. selective activation of D1/D5 receptors could protect synapses from the deleterious action of Abeta oligomers; a selective D1/D5 receptor agonist, prevented the reduction in surface levels of AMPA and NMDA receptors induced by AbetaOs in hippocampal neurons PMID: 21115476
  77. the role of DRD1 in nicotine dependence, and identify genetic and nicotine metabolism profiles that may interact to impact nicotine dependence. PMID: 22495174
  78. the association between age and IIV in the interference condition was linked to D1 receptor losses in task-relevant brain regions. PMID: 22699899
  79. The replication of the association between DRD1 and ADHD in two European cohorts highlights the validity of our finding and supports the involvement of DRD1 in childhood ADHD. PMID: 22404661
  80. Comparison of behavioral studies in wild-type C57BL/6 mice and hemizygous Drd1a mice backcrossed into C57BL/6 background finds open-field locomotion, conditioned place preference, and avoidance learning are indistinguishable in the transgenic lines. PMID: 22764221
  81. significant association between A-48G polymorphism of the DRD1 gene and myocardial infarction PMID: 22277051
  82. Thirty-six tag single nucleotide polymorphisms (SNPs) and one variable-number tandem repeat, spanning the five dopamine receptor genes (DRD1-DRD5) were analyzed as possible causes for antipsychotic induced weight gain PMID: 20714340
  83. This study demonistrated that Significant associations the dopamine receptor 1 (DRD1) and dopamine transporter gene 3' VNTR polymorphisms and aberrant motor behavior. PMID: 20685009
  84. Dopamine D1 receptor mRNA correlated positively with age and dopamine D1 receptor protein expression increased throughout development with adults having the highest D1 protein levels. PMID: 22336227
  85. The rs4532 polymorphism within the DRD1 gene may be associated with negative symptom quantitative trait in schizophrenia. PMID: 22093926
  86. di-L motif at the C-terminus of DR is critical for the glycosylation and cell surface targeting of DR PMID: 22206002
  87. D(1)-D(2) receptor pairs interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no evidence of any D(1)-D(2) receptor transmembrane interaction found. PMID: 22100647
  88. There is no association between dopamine D1 receptor gene polymorphisms and essential hypertension in a group of Turkish subjects. PMID: 21797797
  89. intracellular loop 3 is the critical determinant underlying the subtype-specific regulation of human D1-dopaminergic receptor responsiveness by protein kinase C PMID: 21893192
  90. The data of this study suggested that DRD1 gene polymorphisms confer susceptibility to schizophrenia, and also support the notion that dysfunction of DRD1 is involved in the pathophysiological process of schizophrenia. PMID: 21955727
  91. D1 receptor densities in different pathways are not regulated independently in younger adults, but segregate in older age PMID: 21258043
  92. Individual differences in caudate D1 receptor density are positively associated with individual differences in dorsolateral prefrontal connectivity to right parietal cortex and negatively with medial prefrontal connectivity to right parietal cortex. PMID: 21976513
  93. findings provide support for the notion that D1 receptors in separate brain regions are differentially related to performance in tasks tapping various cognitive domains PMID: 21549202
  94. the genotypic variants of DRD1 might play a role in the susceptibility of Tardive dyskinesia PMID: 21181138
  95. Following a genome wide association study, the authors report a possible association between rs17799914 of DRD1 and schizophrenia. PMID: 21178390
  96. desensitization of the dopamine D1-D2 receptor heteromer-mediated signal can occur by agonist occupancy even without activation and is dually regulated by both the catalytic and RGS domains of GRK2. PMID: 20807772
  97. In the case of polymorphism -48A/G of gene DRD1, a trend was observed towards a more frequent transmission of allele A of gene DRD1 by parents to their children with schizophrenia PMID: 20672519
  98. D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells. PMID: 20592018
  99. The DRD1 expression in the temporal lobe of Alzheimer's disease patients is decressed. PMID: 20164562
  100. These results identify a role of DISC1 in regulating the formation and/or maintenance of primary cilia, and establish subtype-specific targeting of dopamine receptors to the ciliary surface. PMID: 20531939

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Subcellular Location Cell membrane, Multi-pass membrane protein, Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Detected in caudate, nucleus accumbens and in the olfactory tubercle.
Database Links

HGNC: 3020

OMIM: 126449

KEGG: hsa:1812

STRING: 9606.ENSP00000327652

UniGene: Hs.2624

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