HLX Antibody

1. An important association between HLX transcription factor expression and abnormal human placental development in discordant twin pregnancies. PMID: 29212571
2. HLX is a homeobox transcription factor gene which is relatively conserved across species. Hlx homozygous null mice have a short bowel and reduced muscle cells in the diaphragm, closely resembling the anomalies in the two fetuses and we therefore suggest that the HLX mutation in this family could explain the fetal findings PMID: 28898547
3. Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to beta3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT. PMID: 28701693
4. HLX1 is significantly downregulated in HCC and suggests that HLX1 has suppressive effects on HCC growth and metastasis. Accordingly, HLX1 may act as a tumor suppressor in HCC. PMID: 26631039
5. Studies have identified HLX as a novel key transcription factor involved in the regulation of early hematopoiesis and AML pathogenesis. PMID: 23888188
6. The expression levels of Hlx, T-bet, and IFN-gamma were significantly decreased. PMID: 23243425
7. Data suggest that HLX1 is downstream mediator of hepatocyte growth factor- (HGF-) induced cell survival, cell proliferation, and invasive properties of trophoblast cells; thus, both HGF and HLX1 appear to be involved in normal placental development. PMID: 22989111
8. This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia. PMID: 22897850
9. This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth. PMID: 22303482
10. a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease. PMID: 22014209
11. These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions. PMID: 21224470
12. HLX is a mediator of HGF/c-met-dependent trophoblast migration but is not involved in the regulation of trophoblast invsion. PMID: 20554918
13. Cell cycle regulatory genes RB1, MYC, CCNB1, ELK1, JUN, and CDKN1C, which control important trophoblast cell functions, are targets of HLX. PMID: 20008130
14. Decreased HLX1 expression is associated with idiopathic fetal growth restriction PMID: 16436665
15. Hlx expression in activated NK cells temporally controls and limits the monokine-induced production of interferon-gamma. PMID: 17110450
16. We have shown for the first time that a homeobox gene, HLX1, is a downstream effector gene of CSF-1, that HLX1 regulates placental cell proliferation and that CSF-1 acts, at least in part, through HLX1 to control cell proliferation. PMID: 17532041
17. HLX is primarily expressed in cytotrophoblast cell types in the human placenta and propose that HLX is involved in cytotrophoblast proliferation and downregulation of cell differentiation PMID: 18402755
18. polymorphisms in the HLX1 gene increase the risk for childhood asthma. PMID: 19038437
19. gene variants influence the development of childhood asthma PMID: 19295429
20. A risk score model indicates that TBX21 and HLX1 polymorphisms may have synergistic effects on asthma risk. PMID: 19362357
21. Sequence variants in the HLX gene at chromosome 1q41-1q42 in patients with diaphragmatic hernia PMID: 19459883

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HGNC: 4978

OMIM: 142995

KEGG: hsa:3142

STRING: 9606.ENSP00000355870

UniGene: Hs.74870