KAT7 Antibody

Code CSB-PA002860
Size US$100
  • Western Blot analysis of Jurkat cells using HBO1 Polyclonal Antibody
  • Western Blot analysis of various cells using HBO1 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
Hbo 1 antibody; HBO1 antibody; HBOa antibody; Histone acetyltransferase binding to hORC1 antibody; Histone acetyltransferase binding to ORC1 antibody; Histone acetyltransferase KAT7 antibody; Histone acetyltransferase MYST2 antibody; K(lysine) acetyltransferase 7 antibody; KAT 7 antibody; KAT7 antibody; Lysine acetyltransferase 7 antibody; MOZ antibody; MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody; MYST 2 antibody; MYST histone acetyltransferase 2 antibody; MYST protein 2 antibody; MYST-2 antibody; MYST2 antibody; MYST2_HUMAN antibody; SAS 2 antibody; SAS2 and TIP60 protein 2 antibody; TIP60 protein 2 antibody; YBF2/SAS3 antibody; ZC2HC7 antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human HBO1.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development. Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation. Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4. H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II. Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation. H3K14ac is also required for T-cell development. KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing. Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange. Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites. Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity.; Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells.
Gene References into Functions
  1. acts in concert with SNF2H-ACF1 to make the chromosome structure more accessible to canonical nucleotide excision repair factors PMID: 28719581
  2. Hbo1 is another ERalpha coactivator that ubiquitinates ERalpha PMID: 28769019
  3. Histone acetyltransferase binding to ORC1 (HBO1) is upregulated in bladder cancer. PMID: 28796367
  4. The results demonstrate some connections between KAT7 upregulated in RA SFs and RA progression and present the inhibition of KAT7 activity as a novel therapeutic target for interfering RA disease. PMID: 28552525
  5. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented. PMID: 28334966
  6. KAT7-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres. PMID: 27270040
  7. the possible binding sites and biological functions of HBO1, were identified. PMID: 27247147
  8. Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ) represses p53 activity by direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP and the HAT activity of HBO1: [HBZ] PMID: 26625199
  9. This study demonstrates that CRL4(DDB2) is a novel ubiquitin ligase of HBO1. PMID: 26572825
  10. Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival. PMID: 26072331
  11. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter PMID: 25743411
  12. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration. PMID: 24739512
  13. Hbo1 modulated transcription by estrogen receptor-alpha. Hbo1 contributes to degradation of ER-alpha by ubiquitination through lysine 48. PMID: 24125069
  14. Phosphorylated Hbo1 expression is associated with breast cancer. PMID: 23955388
  15. alternate choice of subunits associated with HBO1 can switch its specificity between H4 and H3 tails PMID: 24065767
  16. Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. PMID: 23188630
  17. Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels. PMID: 23319590
  18. The protein domains required for the assembly and function of HBO1/ING complexes were shown. Multiple PHD finger domains in different subunits bound the histone H3 N-terminal tail with a specificity towards lysine 4 methylation. PMID: 22144582
  19. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress PMID: 21856198
  20. HBO1 was an important downstream molecule of ERalpha. PMID: 21040551
  21. HBO1 promote MCM loading in vivo involves the stimulation of large-scale chromatin decondensation to allow access to the underlying DNA substrate. PMID: 20980834
  22. results show that ING4 is a bivalent reader of the chromatin H3K4me3 modification and suggest a mechanism for enhanced targeting of the HBO1 complex to specific chromatin sites PMID: 20053357
  23. H4 acetylation at origins by HBO1 is critical for DNA replication licensing. PMID: 20129055
  24. inhibition by Set/TAF-1beta inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing PMID: 11978794
  25. ordered recruitmenet to thyroid hormone-responsive promoters in vivo PMID: 12034878
  26. Hbo1 is a positive regulatory factor for prereplicative complex assembly. PMID: 16428461
  27. histone acetyltransferase binding to ORC-1 might play an important physiological role in human progesterone receptor signaling PMID: 16645042
  28. reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways PMID: 17954561
  29. Hbo1 depletion results in decreased DNA replication and a failure of Mcm complex binding to chromatin, both of which can be partially rescued by the ectopic expression of WT Hbo1 but not Hbo1-S57A PMID: 18250300
  30. Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation PMID: 18684714
  31. HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. PMID: 18832067
  32. Overexpression of MYST2 is associated with breast cancer. PMID: 19372580
  33. Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder. PMID: 19393168

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Subcellular Location
Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytosol.
Protein Families
MYST (SAS/MOZ) family
Tissue Specificity
Ubiquitously expressed, with highest levels in testis.
Database Links

HGNC: 17016

OMIM: 609880

KEGG: hsa:11143

STRING: 9606.ENSP00000259021

UniGene: Hs.21907

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