Recombinant Human Histone acetyltransferase MYST2(KAT7),partial

Code CSB-RP038644h
Size US$1726
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP038644h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KAT7.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP038644h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) KAT7.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names KAT7
Uniprot No. O95251
Research Area Transcription
Alternative Names Hbo 1; HBO1; HBOa; Histone acetyltransferase binding to hORC1; Histone acetyltransferase binding to ORC1; Histone acetyltransferase KAT7; Histone acetyltransferase MYST2; K(lysine) acetyltransferase 7; KAT 7; KAT7; Lysine acetyltransferase 7; MOZ; MOZ YBF2/SAS3 SAS2 and TIP60 protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2; MYST 2; MYST histone acetyltransferase 2; MYST protein 2; MYST-2; MYST2; MYST2_HUMAN; SAS 2; SAS2 and TIP60 protein 2; TIP60 protein 2; YBF2/SAS3; ZC2HC7
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-214aa
Target Protein Sequence MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHN
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 50.8kDa
Protein Length Partial
Tag Info N-terminal GST-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1
Gene References into Functions
  1. acts in concert with SNF2H-ACF1 to make the chromosome structure more accessible to canonical nucleotide excision repair factors PMID: 28719581
  2. Hbo1 is another ERalpha coactivator that ubiquitinates ERalpha PMID: 28769019
  3. Histone acetyltransferase binding to ORC1 (HBO1) is upregulated in bladder cancer. PMID: 28796367
  4. The results demonstrate some connections between KAT7 upregulated in RA SFs and RA progression and present the inhibition of KAT7 activity as a novel therapeutic target for interfering RA disease. PMID: 28552525
  5. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented. PMID: 28334966
  6. KAT7-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres. PMID: 27270040
  7. the possible binding sites and biological functions of HBO1, were identified. PMID: 27247147
  8. Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ) represses p53 activity by direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP and the HAT activity of HBO1: [HBZ] PMID: 26625199
  9. This study demonstrates that CRL4(DDB2) is a novel ubiquitin ligase of HBO1. PMID: 26572825
  10. Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival. PMID: 26072331
  11. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter PMID: 25743411
  12. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration. PMID: 24739512
  13. Hbo1 modulated transcription by estrogen receptor-alpha. Hbo1 contributes to degradation of ER-alpha by ubiquitination through lysine 48. PMID: 24125069
  14. Phosphorylated Hbo1 expression is associated with breast cancer. PMID: 23955388
  15. alternate choice of subunits associated with HBO1 can switch its specificity between H4 and H3 tails PMID: 24065767
  16. Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. PMID: 23188630
  17. Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels. PMID: 23319590
  18. The protein domains required for the assembly and function of HBO1/ING complexes were shown. Multiple PHD finger domains in different subunits bound the histone H3 N-terminal tail with a specificity towards lysine 4 methylation. PMID: 22144582
  19. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress PMID: 21856198
  20. HBO1 was an important downstream molecule of ERalpha. PMID: 21040551
  21. HBO1 promote MCM loading in vivo involves the stimulation of large-scale chromatin decondensation to allow access to the underlying DNA substrate. PMID: 20980834
  22. results show that ING4 is a bivalent reader of the chromatin H3K4me3 modification and suggest a mechanism for enhanced targeting of the HBO1 complex to specific chromatin sites PMID: 20053357
  23. H4 acetylation at origins by HBO1 is critical for DNA replication licensing. PMID: 20129055
  24. inhibition by Set/TAF-1beta inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing PMID: 11978794
  25. ordered recruitmenet to thyroid hormone-responsive promoters in vivo PMID: 12034878
  26. Hbo1 is a positive regulatory factor for prereplicative complex assembly. PMID: 16428461
  27. histone acetyltransferase binding to ORC-1 might play an important physiological role in human progesterone receptor signaling PMID: 16645042
  28. reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways PMID: 17954561
  29. Hbo1 depletion results in decreased DNA replication and a failure of Mcm complex binding to chromatin, both of which can be partially rescued by the ectopic expression of WT Hbo1 but not Hbo1-S57A PMID: 18250300
  30. Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation PMID: 18684714
  31. HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. PMID: 18832067
  32. Overexpression of MYST2 is associated with breast cancer. PMID: 19372580
  33. Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder. PMID: 19393168

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Subcellular Location Nucleus, nucleoplasm, Cytoplasm, cytosol, Nucleus
Protein Families MYST (SAS/MOZ) family
Tissue Specificity Ubiquitously expressed, with highest levels in testis.
Database Links

HGNC: 17016

OMIM: 609880

KEGG: hsa:11143

STRING: 9606.ENSP00000259021

UniGene: Hs.21907

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