PTGER2 Antibody

Code CSB-PA040059
Size US$167
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  • Western Blot analysis of RAT-KIDNEY MOUSE-BRAIN MOUSE-HEART using EP2 Polyclonal Antibody.

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Product Details

Uniprot No. P43116
Target Names PTGER2
Alternative Names EP2 antibody; PE2R2_HUMAN antibody; PGE receptor EP2 subtype antibody; PGE2 receptor EP2 subtype antibody; Prostaglandin E receptor 2 EP2 subtype antibody; Prostaglandin E receptor 2 subtype EP2 53kDa antibody; Prostaglandin E receptor 2 subtype EP2 antibody; Prostaglandin E2 receptor antibody; Prostaglandin E2 receptor EP2 subtype antibody; Prostanoid EP2 receptor antibody; Ptger2 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the C-terminal region of Human EP2.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IF, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Anti-Inflammatory and Anti-Hyperuricemic Functions of Two Synthetic Hybrid Drugs with Dual Biological Active Sites. Almeer R S, et al,International Journal of Molecular Sciences,2019

Sample species: Mouse
Application: ELISA
Review: Effect of compounds A, B or diclofenac (Diclo) on pro-inflammatory markers in carrageenan (CAR)-induced paw edema in mice. Data are represented as mean ± SD (n = 7); p < 0.05 indicate statistical significance; $, significant change versus normal mice; #, significant change versus the CAR group.
PMID: 31718011

Target Data

Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
Gene References into Functions
  1. EP receptor levels were enhanced in human PASMCs and in lung sections from PAH patients compared to controls. Thus, EP receptors represent a novel therapeutic target for treprostinil, highlighting key pharmacological differences between prostacyclin mimetics used in pulmonary arterial hypertension. PMID: 30103548
  2. PGE2 produced by mesenchymal stem cells contributes to maintenance of self-renewal capacity through EP2 in an autocrine manner, and PGE2 secretion is down-regulated by cell-to-cell contact. PMID: 27230257
  3. this study shows that prostaglandin E2 restrains human Treg cell differentiation via E prostanoid receptor 2-protein kinase A signaling PMID: 28963072
  4. in breast cancer cells overexpression of S1P3 and its activation by S1P has pro-inflammatory and pro-metastatic potential by inducing COX-2 expression and PGE2 signaling via EP2 and EP4. PMID: 27616330
  5. EP2 and EP3 receptors are involved in tolerance induction through IL-10 production by tol-DCs. PMID: 28630103
  6. This is the first report that PGE2 -induced uPAR expression, which stimulates invasiveness of human gastric cancer AGS cells, is mediated by the EP2 receptor-dependent Src/EGFR/JNK1/2, Erk1/2/AP-1, and Src/EGFR/JNK1/2, Erk1/2/NF-kappaB cascades. PMID: 27377703
  7. These results indicate that the ICL2 region of the EP2 receptor is its potential interaction site with Galphas, and that the aromatic side chain moiety at position 143 is a determinant for the accessibility of the ICL2 to the Galphas protein. PMID: 28336329
  8. EP2 receptor activation protects against endoplasmic reticulum stress-dependent mitochondrial apoptosis through down-regulation of p53. PMID: 27321910
  9. that the expression of ERG in prostate cancer is linked to the expression of IL-6 mediated by the prostanoid receptor EP2 PMID: 27012192
  10. mPGES-1 is downregulated via EGR1 and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes PMID: 26538827
  11. Altered expression of EP2 in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta to increase COX-2 and mPGES-1 expression, which results in low PGE2 production PMID: 26560040
  12. Reduced EP2 receptor expression results in resistance to the antiproliferative effects of EP2 signaling in nasal polyp fibroblasts from subjects with AERD and support a role for EP2 signaling in the aberrant growth of nasal polyp tissue. PMID: 26051534
  13. Intracellular EP2 prostanoid receptor promotes cancer-related phenotypes in PC3 prostate cancer cells. PMID: 25828575
  14. In adjusted models, gestations were 3.3 days longer (95%CI 0.6, 6.0) for each interquartile range of PTGER2 DNA methylation. PMID: 24827772
  15. data show a protective role for the PGE2 receptors EP(2) and EP(4) following osmotic changes, through the reduction of human mast cell activity caused by calcium influx impairment and MAP kinase inhibition. PMID: 25329458
  16. mediates inhibitory effect of Prostaglandin E2 on nasal fibroblast migration PMID: 24980222
  17. Overall, our results demonstrate that p53 is a negative regulator of aromatase in the breast and its inhibition by PGE2 provides a novel mechanism for aromatase regulation in obesity and breast cancer. PMID: 25634217
  18. PGE2 markedly enhanced Huh-7 cell invasion and migration ability by upregulating the expression level of Snail protein, and EP2 receptor played an important role in this process. PMID: 24626807
  19. Overexpression of EP2 was more observed in esophageal squamous cell carcinoma than in the control group. Overexpression of EP2 ESCC tissues might play an important role in carcinogenesis and the progression of ESCC. PMID: 24883443
  20. EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression. PMID: 25059824
  21. In Th17 cells, RORC repressed EP2 by directly silencing PTGER2 transcription, and knock down of RORC restored EP2 expression in Th17 cells. PMID: 24812667
  22. The 15-PGDH gene is a MiTF-CX target gene in cervical stromal cells and is down-regulated by PGE2 through EP2 receptors. PMID: 24471568
  23. human albumin solution infusions may be used to reduce circulating PGE2 levels, attenuating immune suppression and reducing the risk of infection in patients with acutely decompensated cirrhosis or ESLD. PMID: 24728410
  24. cyclic tensile force activates ERK1/2 and p38 MAP kinase signaling pathways, and induces COX-2 expression, which is responsible for the sequential PGE2 biosynthesis and release, and mediates the increase in BMP-2 expression at the transcriptional level. PMID: 24561081
  25. Elastogenesis is spatially regulated by PGE-EP4 signaling in the ductus arteriosus. PMID: 24146253
  26. Although human lung mast cells may express both EP2 and EP4 receptors, the principal mechanism by which PGE2 inhibits mediator release in mast cells is by activating EP2 receptors. PMID: 23786281
  27. Data suggest that elevated PGE2 (prostaglandin E2) in peri-implantation uterine lumen stimulates conceptus PTGER2 expression, which in turn promotes trophoblast adhesion via integrins and synthesis/secretion of embryonic signal estradiol-17. PMID: 23861370
  28. Loss of function of EP2- and EP4-mediated PGE2 signaling inhibits adhesion of human endometriotic epithelial and stromal cells through integrin-mediated mechanisms. PMID: 23242524
  29. PGE(2) coordinates control of IL-23 release in a dose-dependent manner by differential use of EP(2) and EP(4) receptors in LPS-activated MoDCs. PMID: 23337716
  30. The expression of the EP2 receptor and Bcl-2 was significantly increased. PMID: 23069790
  31. Targeted interference of EP2/EP4 signal to RalA.GTP may provide benefit to patients diagnosed with advanced kidney cancer. PMID: 22580611
  32. This review article presents a short overview of experimental approaches aimed at manipulation of signaling via EP2 and EP4 receptors that could have therapeutic utility. PMID: 22706114
  33. HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells. PMID: 23048027
  34. Although EP2 methylation status is inversely correlated to expression levels in established breast cancer cell lines, we could not identify that such a correlation existed in tumour-associated stroma cells. PMID: 22929011
  35. Single nucleotide polymorphism in PTGER2 associated with multiple adenomas. PMID: 22551900
  36. Indomethacin has a potential antagonizing effect on human EP(2) receptors. PMID: 22329897
  37. morin inhibited the production of NO and PGE(2). PMID: 22244821
  38. This study suggested that antipsychotics showing association with PGE2-mediated respons. PMID: 22099390
  39. EP2 receptor FuEP2/Ex2 may have a role in suppressing endometrial cancer cell growth PMID: 21419570
  40. PGE2 induces IL-6 in orbital fibroblasts through EP2 receptors and increased gene promoter activity PMID: 21209948
  41. Data show that inhibition of PGE2 receptors EP2 and EP4 suppresses expression and/or activity of MMP1, MMP2, MMP3, MMP7 and MMP9 proteins and increases expression of TIMP1, TIMP2, TIMP3, and TIMP4 proteins. PMID: 21111772
  42. Data suggest that early embryonic signals may regulate fetal-maternal crosstalk in the human endometrium by inducing CXCR4 expression via the PGE-PTGER2-mediated induction of the EGFR, PI3K and ERK1/2 pathways. PMID: 20705717
  43. Data demonstrate that down-regulation of PTGER2 and consequent PGE2 resistance are both mediated by DNA hypermethylation; increased Akt signal transduction is a novel mechanism that promotes DNA hypermethylation during fibrogenesis. PMID: 20889571
  44. miR-16 and miR-21 are directly regulated by the transcription factor NF-kappaB and yet nicotine-promoted cell proliferation is mediated via EP2/4 receptors. PMID: 21081469
  45. Prostaglandin E2 receptor subtype EP2 and EP4 regulated gene expression profiling in ciliary smooth muscle cells. PMID: 20551148
  46. The mRNA levels of EP2 implicated pathways differed significantly in gliomas according to the histological type. PMID: 20382140
  47. E prostanoid (EP) 2 and EP3 have roles in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation during shear-induced interleukin-6 synthesis in chondrocytes PMID: 20516073
  48. analysis of expression of serum vitamin D receptor, cyclooxygenase-2, and 15-hydroxyprostaglandin dehydrogenase in benign and malignant ovarian tissue and 25-hydroxycholecalciferol and prostaglandin E2 in ovarian cancer patients PMID: 20304053
  49. EP1 and EP4 subtypes of prostaglandin E receptors (but not EP2 and EP3 receptors) may be involved in regulation of paracellular permeability in differentiated Caco-2 cell cultures. PMID: 20484658
  50. EP2 is a novel transcriptional target of Wnt3a in dermal papilla cells of human scalp hair follicles PMID: 20347274
  51. Observed induction of the PG receptors EP2 and IP in atherosclerotic femoral arteries in the arterial intima, medial layer, as well as the associated atherosclerotic plaque. PMID: 20357748
  52. Our data imply potential roles of inflammatory reaction by PTGER2 upregulation in carcinogenic process to microsatellite instability -high colorectal cancer. PMID: 20200425
  53. Prostaglandin E2 inhibits the proliferation of human gingival fibroblasts via the EP2 receptor and Epac PMID: 19582788
  54. PGE2 potently inhibits secretion of IFN-alpha by TLR-activated plasmacytoid dendritic cells, an effect mainly mediated by PG receptors E-prostanoid 2 and E-prostanoid 4 PMID: 20018632
  55. PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer PMID: 12051958
  56. effects of PGE2 on monocyte-derived dendritic cells were mediated through increased cyclic adenosine monophosphate by 2 of the known PGE2 receptors, EP2 and EP4 PMID: 12149218
  57. Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines. PMID: 12228765
  58. Data show that down-regulation of prostaglandin E(2) receptor subtype EP(2) receptors represents a potential mechanism for neoplastic progression to an invasive phenotype. PMID: 12466123
  59. shear activates cyclooxygenase-2, via a c-Jun N-terminal kinase2/c-Jun-dependent pathway, which in turn elicits downstream prostaglandin EP2 and EP3a1 receptor mRNA synthesis PMID: 12743126
  60. increased histone H3 acetylation involving the EP2 receptor, protein kinase A, CREB, and CREB binding protein is responsible for PGE(2)-induced StAR gene activation in endometriotic stromal cells. PMID: 12933667
  61. COX-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, EP2 receptor, and EP4 receptor PMID: 14517215
  62. role of araomatic amino acids in i2 loop in Gs coupling PMID: 14699136
  63. elevated EP2 receptor expression may facilitate the PGE(2)-induced release of proangiogenic factors in reproductive tumor cells via intracellular cAMP-mediated transactivation of the EGFR and ERK1/2 pathways PMID: 15044590
  64. Endothelin-1-induced prostaglandin E2-EP2 and EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion PMID: 15347673
  65. PGE2 increases VEGF transcriptionally and involves the Sp-1 binding site via a cAMP-dependent mechanism involving EP2 and EP4 receptors PMID: 15970595
  66. a novel proinflammatory and proamyloidogenic function for the PGE2 EP2 receptor is demonstrated in a model of familial Alzheimer's disease. PMID: 16267225
  67. significantly reduced expression of PGE(2) receptors on nasal mucosa inflammatory leukocytes in the aspirin-sensitive compared with nonaspirin-sensitive rhinosinusitis patients PMID: 16461132
  68. Together, the results suggest that the overexpression of the human EP2 receptor plays a significant role in the protumorigenic action of PGE2 in mouse skin. PMID: 16607275
  69. prostaglandin-endoperoxide synthase 2 polymorphisms, prostaglandin-E receptor 2 polymorphisms, and C-reactive protein concentrations may have a role in atherothrombosis PMID: 16879213
  70. These data indicate that PGE(2) inhibits fibroblast activation in primary lung fibroblasts via binding of EP2 receptor and production of cyclic AMP; inhibition of collagen I proceeds via activation of PKA. PMID: 17028262
  71. These results suggest that the COX-2-PGE(2) pathway may be involved in IL-8 production in gastric epithelial cells. PMID: 17078003
  72. EP2 mRNA was significantly higher in normal colon tissue compared with tumor tissue. PMID: 17290397
  73. Selective stimulation of the EP2 receptor subtype, leading to epidermal growth factor receptor (EGFR) transactivation via protein kinase A PMID: 17384145
  74. NB cells may lose responsiveness to PTGER2-mediated growth inhibition/apoptosis through epigenetic silencing of PTGER2 and/or disruption of downstream cAMP-dependent pathway during the neuroblastomagenesis. PMID: 17533365
  75. treatment of LS174T cells with indomethacin causes a down regulation of EP2 prostanoid receptors PMID: 17555711
  76. Role of EP2 receptor in mediating the PGE2 effect on stimulating cyst formation may have direct pharmacological implications for the treatment of polycystic kidney disease. PMID: 17728378
  77. PGE(2) via EP(2) and EP(4) activates the cAMP-->PKA-->CREB pathway leading to enhanced CYP19 transcription and increased aromatase activity through BRCA1 and p300 PMID: 18083712
  78. herpes simplex virus type 1 infected mature monocyte-derived dendritic cells demonstrated a dramatic down-regulation of the expression of the EP2 and EP4 receptors PMID: 18086382
  79. PGE2 receptors were expressed in both NCI-H292 and human nasal epithelial cells. PMID: 18254372
  80. results showed that EP2 is expressed in trigeminal neurons (58% of total neurons) and is co-expressed in TRPV(1)-positive neurons (64% of TRPV(1)-positive neurons. PMID: 18296611
  81. CCR7 and the EP2/EP4 receptor signaling pathway are down-stream targets for COX-2 to enhance the migration of breast cancer cells toward LECs and to promote lymphatic invasion PMID: 18319253
  82. Prostaglandin E(2), via the prostanoid receptor EP2 and subsequent cAMP elevation, downregulates mRNA and protein levels of protease-activated receptor-1 in human lung fibroblasts. PMID: 18537828
  83. PTGER2 methylation was present with greater frequency in nonsmall cell lung cancer with EGFR mutation. PMID: 18666211
  84. A new approach for blocking E-prostanoid receptor-mediated cell signaling using a soluble chimeric EP2 fragment, is described. PMID: 18790761
  85. findings show the G(s)-coupled EP(2) receptor closes K(Ca)3.1 in lung mast cells and attenuates both chemokine- and PGE(2)-dependent lung mast cell migration PMID: 18792407
  86. PGE(2) induces angiogenesis in prostate cancer through EP2 and EP4. PMID: 18829529
  87. Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease. PMID: 18989535
  88. Overexpression of EP2 is associated with esophageal squamous cell carcinoma. PMID: 19050969
  89. Results suggest that prostaglandin E2 mainly induces the activation of beta(1)-integrins via the EP(2) receptor in human coronary arterial endothelial cells. PMID: 19169646
  90. PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression. PMID: 19273625
  91. opposite regulation of proinflammatory IL-6 and prodestructive MMP-1 by PGE(2) via EP2 in rheumatoid arthritis fibroblasts PMID: 19542367
  92. demonstrates that co-activation of the FP and EP2 receptors results in enhanced release of cAMP via FP receptor-G alpha(q)-Ca(2+)-calmodulin pathway by activating calcium sensitive adenylyl cyclase 3 isoform. PMID: 19782748
  93. PGE2, via EP2 receptor, enhances PTEN function in lung fibroblasts to inhibit directional migration PMID: 15539459

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Placenta and lung.
Database Links

HGNC: 9594

OMIM: 176804

KEGG: hsa:5732

STRING: 9606.ENSP00000245457

UniGene: Hs.2090

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