PTGER4 Antibody

Code CSB-PA018973LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: Rat liver tissue, Rat kidney tissue
    All lanes: PTGER4 antibody at 3.2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 54 kDa
    Observed band size: 54 kDa

  • Immunofluorescence staining of HepG2 cells with CSB-PA018973LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PTGER4 Polyclonal antibody
Uniprot No. P35408
Target Names PTGER4
Alternative Names EP 4 antibody; EP4 antibody; EP4R antibody; MGC126583 antibody; PE2R4_HUMAN antibody; PGE receptor EP4 subtype antibody; PGE2 receptor EP4 subtype antibody; Prostaglandin E receptor 4 antibody; Prostaglandin E receptor 4 subtype EP4 antibody; Prostaglandin E2 receptor antibody; Prostaglandin E2 receptor EP4 subtype antibody; Prostanoid EP4 receptor antibody; PTGER 2 antibody; PTGER 4 antibody; PTGER2 antibody; PTGER4 antibody
Raised in Rabbit
Species Reactivity Human, Rat
Immunogen Recombinant Human Prostaglandin E2 receptor EP4 subtype protein (354-472AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Gene References into Functions
  1. Case Report: elevated EP4 expression in pulmonary hypertension patient with dissecting pulmonary aneurysm. PMID: 28108433
  2. Collectively, these results indicate that COX-1/PGE2/EP4 upregulates the beta-arr1 mediated Akt signaling pathway to provide mucosal protection in colitis. PMID: 28432343
  3. Reprogramming of mammary epithelial cells can result from EP4 -mediated stem cell property transfer by extracellular vesicles/exosomes containing caveolae-associated proteins, between mammary basal and luminal epithelial cells. PMID: 27506158
  4. High PTGER4 methylation is associated with Lung cancer. PMID: 27544059
  5. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis. PMID: 27450806
  6. The results show that stimulation with the selective EP4 agonist CAY10598 or PGE2 promotes invadopodia-mediated degradation of the ECM, as well as the invasion of breast cancer cells in in vitro models. PMID: 28094049
  7. EP4 expression can promote the development of resistance to aromatase inhibitor therapy for breast cancer PMID: 27869171
  8. Findings suggest SUMO-1 protein and PGE2 receptor subtype 4 (EP4) as two potential targets for new therapeutic or prevention strategies for endometrial cancers. PMID: 27230680
  9. GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR interactive signaling. PMID: 27010855
  10. The cross-talk between SP1 and p65, and the positive feedback regulatory loop of PI3-K/Akt signaling by EP4 contribute to the overall responses of solamargine in this process PMID: 26689593
  11. The PTGER4 gene is a candidate risk factor for radiological progression in rheumatoid arthritis PMID: 26538147
  12. IP and EP4 receptors have a role in prostanoid regulation of angiogeneis PMID: 26188701
  13. miRNA 526b is a COX-2 upregulated, oncogenic miRNA promoting stem-like cells, the expression of which follows EP4 receptor-mediated signaling. PMID: 25733698
  14. Altered inhibitory function of the EP4R in eosinophils and monocytes from aspirin-intolerant patients PMID: 25531811
  15. TGF-beta2 therefore promotes the adhesion and invasiveness of virulent macrophages by modulating COX2, EP4, and PKIG transcription to initiate a prostaglandin E2 (PGE2)-driven autostimulatory loop that augments PKA and EPAC activities. PMID: 25690101
  16. PGE2 upregulates c-myc in hepatocellular carcinoma via PTGER4 signaling. PMID: 25109834
  17. Gene expression analysis revealed that three gene BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. PMID: 25670004
  18. The PTGER4 modulating variant rs7720838 increases susceptibility for Crohn's disease and might resemble a risk factor for stricturing disease behavior. PMID: 24793213
  19. the microsomal PGE2-synthase-1/PGE-receptor-4 axis is increased by smoking in human abdominal aortic aneurysms PMID: 24876670
  20. potential relevance of the COX-2/mPGES-1/EP-4 axis in the AAA-associated hypervascularization PMID: 24133193
  21. JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients. PMID: 24069348
  22. Four single nucleotide polymorphisms in two genes in the PGE2 family, PTGES2 and PTGER4, were significantly associated with primary graft dysfunction after lung transplantation. PMID: 24467603
  23. PGE2 production induced by pathogen recognition receptors/p38 MAPK signaling is up-regulated by EP4-triggered signaling to maintain an effective PGE2 concentration. PMID: 23759445
  24. This is the first report to demonstrate that Lymphocytic colitis is associated with increased TNF-alpha, INF-gamma and IL-8 concurrent with a marked up-regulation of EP4. PMID: 23613969
  25. PGE2 induces MUC2 and MUC5AC expression in intrahepatic biliary epithelial cells via EP4-p38MAPK signaling. PMID: 23619266
  26. Data indicate that PGE2 regulates pancreatic stellate cell profibrotic activities via EP4 receptor, thus suggesting EP4 receptor as useful therapeutic target for pancreatic cancer to reduce desmoplasia. PMID: 23090667
  27. Activation of E-type prostanoid (EP) 4 receptor by PGE(2) or an EP4-selective agonist (ONO AE1-329) enhanced the barrier function of human microvascular lung endothelial cells. PMID: 22704539
  28. Single nucleotide polymorphisms in the PTGER4 gene regulatory sequences are strongly associated with Crohn's disease susceptibility. PMID: 23300802
  29. The PTGER4 -1254 G allele demonstrated a higher frequency in aspirin-intolerant chronic urticaria (AICU)patients and lower promoter activity with decreased expression of PTGER4 and contributes to the development of AICU. PMID: 22695889
  30. different EP receptors (EP(1-4)) to PGE(2)-induced anion secretion in human and mouse colon mucosa PMID: 22732652
  31. With HO as a model oxidant stress, stimulation of CFTR seems to involve PGE production and likely EP receptor activation in Calu-3 airway epithelial cells. PMID: 22362924
  32. EP-4 receptor expression is modulated at the post-transcriptional level by miR-101. PMID: 22353936
  33. Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions PMID: 21683675
  34. PGE(2) enhances IL-8 production via EP4 receptor coupled to G(s) protein in human pulmonary microvascular endothelial cells PMID: 22080750
  35. Prostaglandin EP4 receptor enhances BCR-induced apoptosis of immature B cells PMID: 21600299
  36. EP4 receptors are expressed by human eosinophils, and are also present on infiltrating leukocytes in inflamed human nasal mucosa. PMID: 21365278
  37. Human kidney cells evidence increased EP4 and decreased Rap1GAP expression levels in the malignant compared with benign samples. PMID: 21832044
  38. Data suggest that PGE(2) -EP4 signaling might be protective against allergic responses by inhibiting the interaction of eosinophils with the endothelium and might hence be a useful therapeutic option for controlling inappropriate eosinophil infiltration. PMID: 21681739
  39. findings indicate early divergence in the signaling pathways stimulated by strain and establish PGE2/EP4 as the pathway used by strain to regulate Sost expression. PMID: 21723865
  40. found that PGE(2) and hypoxia independently induce expression of PTGER4 indicating two independent pathways regulating prostanoid receptor expression PMID: 21589857
  41. chronic activation of the EP receptor is associated with increased production of mediators likely to increase the pro-inflammatory milieu of airway epithelial cells. PMID: 20970516
  42. Results are suggestive of platelet EP4 receptor activation as a novel antithrombotic strategy. PMID: 21071691
  43. Data seem to rule out a major influence of these polymorphisms on UC or RA predisposition. PMID: 20561984
  44. Increased expression of PGE2 in the lung tumor microenvironment may initiate a mitogenic signaling cascade composed of EP4, betaArrestin1, and c-Src which mediates cancer cell migration. PMID: 20353998
  45. regulate activities exhibited by IBC cells that have been associated with the aggressive phenotype. ep4 regulate invasion PMID: 20503412
  46. EP4 overexpression, via AR activation, supports an important mechanism for castration-resistant progression of prostate cancer. PMID: 20145136
  47. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20014019
  48. The EP4 agonist PF-04475270 is a novel ocular hypotensive compound which is bioavailable following topical dosing and effectively lowers intraocular pressure. PMID: 19445930
  49. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. PMID: 11782353
  50. Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. PMID: 11876748

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Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family
Tissue Specificity High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Database Links

HGNC: 9596

OMIM: 601586

KEGG: hsa:5734

STRING: 9606.ENSP00000302846

UniGene: Hs.199248

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