PTGER4

Prostaglandin E receptor 4 (PTGER4), also known as EP4, is a key member of the G - protein - coupled receptor family. It binds prostaglandin E2 with high affinity. By activating the Gs protein, it elevates intracellular cAMP levels, triggering downstream signaling cascades. This receptor is involved in the cAMP - PKA and PI3K - AKT signaling pathways.
PTGER4 is associated with various diseases, including inflammation, cancer, and cardiovascular diseases. Due to its crucial role, it has become an attractive target for drug development. Currently, several small - molecule antagonists and agonists are in pre - clinical and clinical trials, aiming to treat related diseases effectively.

Popular Product:

PTGER4 Antibody (CSB-PA018973LA01HU)

Validated Data

Western Blot
Positive WB detected in: Rat liver tissue, Rat kidney tissue
All lanes: PTGER4 antibody at 3.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA018973LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following PTGER4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PTGER4 Antibodies

PTGER4 Proteins

PTGER4 Antibodies

PTGER4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002354	PTGER4 Antibody	Human	WB, IF, ELISA
CSB-PA826092	PTGER4 Antibody	Human	ELISA,WB
CSB-PA949253	PTGER4 Antibody	Human	ELISA,WB
CSB-PA018973LA01HU	PTGER4 Antibody	Human, Rat	ELISA, WB, IF
CSB-PA018973LB01HU	PTGER4 Antibody, HRP conjugated	Human	ELISA
CSB-PA018973LC01HU	PTGER4 Antibody, FITC conjugated	Human

PTGER4 Proteins

PTGER4 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-CF630694RB	Recombinant Rabbit Prostaglandin E2 receptor EP4 subtype (PTGER4)	in vitro E.coli expression system
CSB-YP630694RB1 CSB-EP630694RB1 CSB-BP630694RB1 CSB-MP630694RB1 CSB-EP630694RB1-B	Recombinant Rabbit Prostaglandin E2 receptor EP4 subtype (PTGER4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGER4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF018973HU	Recombinant Human Prostaglandin E2 receptor EP4 subtype (PTGER4)	in vitro E.coli expression system
CSB-YP018973HU1 CSB-EP018973HU1 CSB-BP018973HU1 CSB-MP018973HU1 CSB-EP018973HU1-B	Recombinant Human Prostaglandin E2 receptor EP4 subtype (PTGER4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGER4 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF018973RA	Recombinant Rat Prostaglandin E2 receptor EP4 subtype (Ptger4)	in vitro E.coli expression system
CSB-YP018973RA1 CSB-EP018973RA1 CSB-BP018973RA1 CSB-MP018973RA1 CSB-EP018973RA1-B	Recombinant Rat Prostaglandin E2 receptor EP4 subtype (Ptger4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGER4 Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF822095EQV	Recombinant Pan troglodytes Prostaglandin E2 receptor EP4 subtype (PTGER4)	in vitro E.coli expression system
CSB-YP822095EQV1 CSB-EP822095EQV1 CSB-BP822095EQV1 CSB-MP822095EQV1 CSB-EP822095EQV1-B	Recombinant Pan troglodytes Prostaglandin E2 receptor EP4 subtype (PTGER4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGER4 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF822647BO	Recombinant Bovine Prostaglandin E2 receptor EP4 subtype (PTGER4)	in vitro E.coli expression system
CSB-YP822647BO1 CSB-EP822647BO1 CSB-BP822647BO1 CSB-MP822647BO1 CSB-EP822647BO1-B	Recombinant Bovine Prostaglandin E2 receptor EP4 subtype (PTGER4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTGER4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF018973MO	Recombinant Mouse Prostaglandin E2 receptor EP4 subtype (Ptger4)	in vitro E.coli expression system
CSB-YP018973MO1 CSB-BP018973MO1 CSB-MP018973MO1 CSB-EP018973MO1-B	Recombinant Mouse Prostaglandin E2 receptor EP4 subtype (Ptger4), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application