Recombinant Human Prostaglandin E2 receptor EP4 subtype (PTGER4)

1. Case Report: elevated EP4 expression in pulmonary hypertension patient with dissecting pulmonary aneurysm. PMID: 28108433
2. Collectively, these results indicate that COX-1/PGE2/EP4 upregulates the beta-arr1 mediated Akt signaling pathway to provide mucosal protection in colitis. PMID: 28432343
3. Reprogramming of mammary epithelial cells can result from EP4 -mediated stem cell property transfer by extracellular vesicles/exosomes containing caveolae-associated proteins, between mammary basal and luminal epithelial cells. PMID: 27506158
4. High PTGER4 methylation is associated with Lung cancer. PMID: 27544059
5. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis. PMID: 27450806
6. The results show that stimulation with the selective EP4 agonist CAY10598 or PGE2 promotes invadopodia-mediated degradation of the ECM, as well as the invasion of breast cancer cells in in vitro models. PMID: 28094049
7. EP4 expression can promote the development of resistance to aromatase inhibitor therapy for breast cancer PMID: 27869171
8. Findings suggest SUMO-1 protein and PGE2 receptor subtype 4 (EP4) as two potential targets for new therapeutic or prevention strategies for endometrial cancers. PMID: 27230680
9. GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR interactive signaling. PMID: 27010855
10. The cross-talk between SP1 and p65, and the positive feedback regulatory loop of PI3-K/Akt signaling by EP4 contribute to the overall responses of solamargine in this process PMID: 26689593
11. The PTGER4 gene is a candidate risk factor for radiological progression in rheumatoid arthritis PMID: 26538147
12. IP and EP4 receptors have a role in prostanoid regulation of angiogeneis PMID: 26188701
13. miRNA 526b is a COX-2 upregulated, oncogenic miRNA promoting stem-like cells, the expression of which follows EP4 receptor-mediated signaling. PMID: 25733698
14. Altered inhibitory function of the EP4R in eosinophils and monocytes from aspirin-intolerant patients PMID: 25531811
15. TGF-beta2 therefore promotes the adhesion and invasiveness of virulent macrophages by modulating COX2, EP4, and PKIG transcription to initiate a prostaglandin E2 (PGE2)-driven autostimulatory loop that augments PKA and EPAC activities. PMID: 25690101
16. PGE2 upregulates c-myc in hepatocellular carcinoma via PTGER4 signaling. PMID: 25109834
17. Gene expression analysis revealed that three gene BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. PMID: 25670004
18. The PTGER4 modulating variant rs7720838 increases susceptibility for Crohn's disease and might resemble a risk factor for stricturing disease behavior. PMID: 24793213
19. the microsomal PGE2-synthase-1/PGE-receptor-4 axis is increased by smoking in human abdominal aortic aneurysms PMID: 24876670
20. potential relevance of the COX-2/mPGES-1/EP-4 axis in the AAA-associated hypervascularization PMID: 24133193
21. JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients. PMID: 24069348
22. Four single nucleotide polymorphisms in two genes in the PGE2 family, PTGES2 and PTGER4, were significantly associated with primary graft dysfunction after lung transplantation. PMID: 24467603
23. PGE2 production induced by pathogen recognition receptors/p38 MAPK signaling is up-regulated by EP4-triggered signaling to maintain an effective PGE2 concentration. PMID: 23759445
24. This is the first report to demonstrate that Lymphocytic colitis is associated with increased TNF-alpha, INF-gamma and IL-8 concurrent with a marked up-regulation of EP4. PMID: 23613969
25. PGE2 induces MUC2 and MUC5AC expression in intrahepatic biliary epithelial cells via EP4-p38MAPK signaling. PMID: 23619266
26. Data indicate that PGE2 regulates pancreatic stellate cell profibrotic activities via EP4 receptor, thus suggesting EP4 receptor as useful therapeutic target for pancreatic cancer to reduce desmoplasia. PMID: 23090667
27. Activation of E-type prostanoid (EP) 4 receptor by PGE(2) or an EP4-selective agonist (ONO AE1-329) enhanced the barrier function of human microvascular lung endothelial cells. PMID: 22704539
28. Single nucleotide polymorphisms in the PTGER4 gene regulatory sequences are strongly associated with Crohn's disease susceptibility. PMID: 23300802
29. The PTGER4 -1254 G allele demonstrated a higher frequency in aspirin-intolerant chronic urticaria (AICU)patients and lower promoter activity with decreased expression of PTGER4 and contributes to the development of AICU. PMID: 22695889
30. different EP receptors (EP(1-4)) to PGE(2)-induced anion secretion in human and mouse colon mucosa PMID: 22732652
31. With HO as a model oxidant stress, stimulation of CFTR seems to involve PGE production and likely EP receptor activation in Calu-3 airway epithelial cells. PMID: 22362924
32. EP-4 receptor expression is modulated at the post-transcriptional level by miR-101. PMID: 22353936
33. Prostaglandin E2 produced by Entamoeba histolytica signals via EP4 receptor and alters claudin-4 to increase ion permeability of tight junctions PMID: 21683675
34. PGE(2) enhances IL-8 production via EP4 receptor coupled to G(s) protein in human pulmonary microvascular endothelial cells PMID: 22080750
35. Prostaglandin EP4 receptor enhances BCR-induced apoptosis of immature B cells PMID: 21600299
36. EP4 receptors are expressed by human eosinophils, and are also present on infiltrating leukocytes in inflamed human nasal mucosa. PMID: 21365278
37. Human kidney cells evidence increased EP4 and decreased Rap1GAP expression levels in the malignant compared with benign samples. PMID: 21832044
38. Data suggest that PGE(2) -EP4 signaling might be protective against allergic responses by inhibiting the interaction of eosinophils with the endothelium and might hence be a useful therapeutic option for controlling inappropriate eosinophil infiltration. PMID: 21681739
39. findings indicate early divergence in the signaling pathways stimulated by strain and establish PGE2/EP4 as the pathway used by strain to regulate Sost expression. PMID: 21723865
40. found that PGE(2) and hypoxia independently induce expression of PTGER4 indicating two independent pathways regulating prostanoid receptor expression PMID: 21589857
41. chronic activation of the EP receptor is associated with increased production of mediators likely to increase the pro-inflammatory milieu of airway epithelial cells. PMID: 20970516
42. Results are suggestive of platelet EP4 receptor activation as a novel antithrombotic strategy. PMID: 21071691
43. Data seem to rule out a major influence of these polymorphisms on UC or RA predisposition. PMID: 20561984
44. Increased expression of PGE2 in the lung tumor microenvironment may initiate a mitogenic signaling cascade composed of EP4, betaArrestin1, and c-Src which mediates cancer cell migration. PMID: 20353998
45. regulate activities exhibited by IBC cells that have been associated with the aggressive phenotype. ep4 regulate invasion PMID: 20503412
46. EP4 overexpression, via AR activation, supports an important mechanism for castration-resistant progression of prostate cancer. PMID: 20145136
47. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20014019
48. The EP4 agonist PF-04475270 is a novel ocular hypotensive compound which is bioavailable following topical dosing and effectively lowers intraocular pressure. PMID: 19445930
49. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. PMID: 11782353
50. Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. PMID: 11876748

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HGNC: 9596

OMIM: 601586

KEGG: hsa:5734

STRING: 9606.ENSP00000302846

UniGene: Hs.199248