RCVRN Antibody

Code CSB-PA019519GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
23 kDa photoreceptor cell-specific protein antibody; Cancer associated retinopathy protein antibody; Cancer-associated retinopathy protein antibody; CAR antibody; CAR protein antibody; p26 antibody; Protein CAR antibody; RCV1 antibody; RCVRN antibody; RECO_HUMAN antibody; Recoverin antibody; S-modulin antibody
Raised in
Species Reactivity
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light.
Gene References into Functions
  1. High RCVRN expression is associated with renal tumors. PMID: 26813565
  2. Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands. PMID: 26584024
  3. C39D substitution reduces alpha-helical content, decreases thermal stability and suppresses membrane association. PMID: 21344177
  4. Aberrant hypomethylation of the recoverin gene region, overlapping the promoter up-stream of the first exon and the first exon itself, is involved in the aberrant expression of recoverin in tumor cells. PMID: 20812967
  5. recoverin has a pathological role in cancer-associated retinopathy PMID: 12596918
  6. There are cis-acting elements in the 5' non-coding region of the recoverin gene that are involved in the activation and suppression of gene expression. PMID: 12789533
  7. Human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR. KK0206 might be important for further research on SCLC related retinopathy. PMID: 17374419
  8. A GRK1 region close to its C-terminus also seemed to be the binding site for S-modulin/recoverin. PMID: 18266817

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Subcellular Location
Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Photoreceptor outer segment membrane; Lipid-anchor; Cytoplasmic side. Perikaryon.
Protein Families
Recoverin family
Tissue Specificity
Retina and pineal gland.
Database Links

HGNC: 9937

OMIM: 179618

KEGG: hsa:5957

STRING: 9606.ENSP00000226193

UniGene: Hs.80539

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