RCVRN Antibody

Code CSB-PA019519HA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western blot
    All lanes: RCVRN antibody at 2µg/ml + Mouse eye tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 24 kDa
    Observed band size: 24 kDa
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) RCVRN Polyclonal antibody
Uniprot No. P35243
Target Names RCVRN
Alternative Names 23 kDa photoreceptor cell-specific protein antibody; Cancer associated retinopathy protein antibody; Cancer-associated retinopathy protein antibody; CAR antibody; CAR protein antibody; p26 antibody; Protein CAR antibody; RCV1 antibody; RCVRN antibody; RECO_HUMAN antibody; Recoverin antibody; S-modulin antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Recoverin protein (2-200AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Anti-recoverin antibodies indicate fundus abnormalities in systemic lupus erythematosus. M Li,Lupus,2020

Applications: ELISA
Antibody dilution factor: 1:250, 1:500, 1:1000,1:2000, 1:4000, 1:8000 and 1:16,000
Review: Then, wells were incubated with serum samples diluted at 1:50 and 5mg/mL rabbit anti-recoverin antibodies (CUSABIO) diluted at 1:250, 1:500, 1:1000,1:2000, 1:4000, 1:8000 and 1:16,000 sequentially for 1 h at 37 C.
PMID: 32703115

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Target Data

Function Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
Gene References into Functions
  1. High RCVRN expression is associated with renal tumors. PMID: 26813565
  2. Crystal Structure of Recoverin with Calcium Ions Bound to Both Functional EF Hands. PMID: 26584024
  3. C39D substitution reduces alpha-helical content, decreases thermal stability and suppresses membrane association. PMID: 21344177
  4. Aberrant hypomethylation of the recoverin gene region, overlapping the promoter up-stream of the first exon and the first exon itself, is involved in the aberrant expression of recoverin in tumor cells. PMID: 20812967
  5. recoverin has a pathological role in cancer-associated retinopathy PMID: 12596918
  6. There are cis-acting elements in the 5' non-coding region of the recoverin gene that are involved in the activation and suppression of gene expression. PMID: 12789533
  7. Human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR. KK0206 might be important for further research on SCLC related retinopathy. PMID: 17374419
  8. A GRK1 region close to its C-terminus also seemed to be the binding site for S-modulin/recoverin. PMID: 18266817

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Protein Families Recoverin family
Tissue Specificity Retina and pineal gland.
Database Links

HGNC: 9937

OMIM: 179618

KEGG: hsa:5957

STRING: 9606.ENSP00000226193

UniGene: Hs.80539

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