Recombinant Human E3 ubiquitin-protein ligase CBL-B (CBLB), partial

1. This study aimed to investigate the difference between the expression of Cbl-b in lung squamous cell carcinoma and adenocarcinoma. PMID: 29384143
2. miR-891b regulated the Smad3/ p21 axis by directly targeting the Cbl-b gene to inhibit the proliferative ability of pancreatic adenocarcinoma cells. PMID: 27494897
3. our findings suggest that E3 ubiquitin ligase Cbl-b modulates the interplay between effector and Tregs, particularly resistance to the suppression phenotype by regulating the K63 polyubiquitination profile in lupus Tregs. PMID: 28940360
4. These results suggest that Cbl-b is an important factor for maintenance of the epithelial phenotype and inhibition of cell migration in MDR gastric and breast cancer cells. PMID: 28334634
5. Silencing CBLB in human monocyte-derived macrophages resulted in increased cytokine production and impaired down-modulation of dectin-1 and dectin-2 expression after C.albicans exposure. PMID: 27428899
6. this study shows that rs2305035 genotypes in CBLB are associated with clinical and radiation pneumonitis risk among patients with non-small-cell lung cancer treated with definitive radiotherapy PMID: 26732495
7. Results suggest that Cbl-b improves the prognosis of RANK-expressing breast cancer patients by inhibiting RANKL-induced breast cancer cell migration and metastasis. PMID: 26087197
8. direct interaction between Cblin and the TKB domain of Cbl-b PMID: 26874193
9. findings suggest that Cbl-b limits NGF-TrkA signaling to control the length of neurites. PMID: 25921289
10. Translocation of Cbl-b from the nucleus to the cytoplasm prevented the localization of P-gp to caveolae resulting in the reversal of multidrug resistance through the ubiquitination and degradation of c-Src. PMID: 25788263
11. Our results suggest that celecoxib-mediated upregulation of Cbl-b is responsible, at least in part, for the additive antitumor effect of celecoxib and rapamycin via inhibition of rapamycin-induced Akt activation. PMID: 25701378
12. results show that Cbl-b suppresses human ORMDL3 expression through STAT6 PMID: 26112603
13. Low CBLB expression is associated with glioma cell invasion. PMID: 25691332
14. The data suggest a role of the CBLB rs12487066 variant in the interactions of a genetic risk factor and IFN function during viral infections in multiple sclerosis. PMID: 25261476
15. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. PMID: 24885194
16. Cbl-b knockdown caused significant increase of phosphorylation of EGFR, ERK and Akt, decrease of mitochondrial membrane potential, and increase of expression ratio of Bcl-2/Bax. PMID: 24351824
17. that icotinib-induced upregulation of Cbl-b is responsible, at least in part, for the antitumor effect of icotinib via the inhibition of phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinase pathways in EGFR-mutated NSCLC cells. PMID: 23586056
18. abnormal peripheral tolerance in SLE is caused by a deficiency in Cbl-b, and that this ubiquitin ligase plays a key role in regulating T-cell receptor signaling during the induction of peripheral tolerance. PMID: 23280105
19. FOXP3 mRNA expression correlated with CBLB and ITCH in MS patients. PMID: 23039885
20. Pooled analysis corroborated the effect on multiple sclerosis predisposition of three genes: TMEM39A, IL12B, and CBLB PMID: 22194214
21. Data show that bufalin-induced down-regulation of Cbl-b contributed to the up-regulation of TRAIL Receptors DR4 and DR5. PMID: 22447040
22. Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b PMID: 22158902
23. Over expression of TGF-beta and CTLA-4 leads to T cell hyporesponsiveness, a major hallmark of leprosy, by increasing the expression of Cbl-b. PMID: 21807564
24. data suggest that Cbl-b may contribute to the deregulated activation of T lymphocytes observed in systemic lupus erythematosus (SLE); a significant association between the 2126(A/G) SNP and SLE was detected PMID: 21558139
25. CBLB mutation is asssociated with chronic myelogenous leukemia. PMID: 21346257
26. Deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a in T cells were found to be associated with cholesterol-dependent-dismantling of HLA-DR rafts in macrophages in leprosy progression. PMID: 21453975
27. These data provide further evidence of the association of MS disease with variation within CBLB. PMID: 21037273
28. Interplay between transgenic Cblb-dependent T cell anergy and other mechanisms prevents organ-specific islet-cell autoimmunity. PMID: 21248249
29. Cbl-b plays a positive modulatory role in GPVI-dependent platelet signaling, which translates to an important regulatory role in hemostasis and thrombosis in vivo PMID: 20400514
30. Cbl-b and itch are key regulators of peripheral T-cell tolerance [review] PMID: 20395198
31. Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells. PMID: 12697763
32. Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation. PMID: 12935897
33. Cbl-b is a negative regulator of both Lyn-Syk-LAT and Gab2mediated complementary signaling pathways in FcepsilonRI-mediated mast cell activation PMID: 14604964
34. genetic interaction between the CTLA4 and CBLB genes in type 1 diabetes PMID: 15629882
35. NF-kappaB activity is enhanced by a PI3K signal mediated by Cbl-b and Rho PMID: 15922296
36. results suggest that Cbl-b- or atrogin-1-mediated ubiquitination plays an important role in unloading-induced muscle atrophy, and that unloading stress may preferentially inhibit transcriptional responses in skeletal muscle PMID: 16868939
37. In a primary analysis, no evidence for an association of the CBLB SNP rs3772534 with disease was found in either sample set in type 1 diabetes. PMID: 17209142
38. the host ubiquitin ligase Cbl-b interacts with the type III-secreted effector exotoxin T (ExoT) and plays a key role in vivo in limiting bacterial dissemination mediated by ExoT PMID: 17235393
39. F328L mutation is involved in the development of autoimmune diseases including type 1 diabetes, and also provide insight into the structure-function relationship of CBLB protein PMID: 18201552
40. Cbls suppress cell death in healthy neurons at least in part by inhibiting the ability of mixed lineage kinases to activate JNK signaling. PMID: 19546888

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HGNC: 1542

OMIM: 604491

KEGG: hsa:868

STRING: 9606.ENSP00000264122

UniGene: Hs.430589