CBLB, the proto-oncogene B of Casitas B lymphoma, is encoded by the CBLB gene in the human genome. As a RING-type E3 ubiquitin ligase and a member of the CBL family, CblB is pivotal in the modulation of T cell function. It facilitates the ubiquitination of specific substrates, thereby regulating their degradation or activity and negatively modulating immune responses. The inhibition of CBLB activity can bolster anti-tumor immunity by curtailing tumor cells' immune evasion, rendering CBLB a significant candidate for cancer immunotherapy research and application.
Recombinant Human E3 ubiquitin-protein ligase CBL-B (CBLB), partial
Source: Yeast
Source: E.coli
Source: Baculovirus
Source: Mammalian cell
Source: In Vivo Biotinylation in E.coli
The following CBLB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CBLB Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004579GA01HU | CBLB Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IP |
CBLB Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP623789HU CSB-EP623789HU CSB-BP623789HU CSB-MP623789HU CSB-EP623789HU-B |
Recombinant Human E3 ubiquitin-protein ligase CBL-B (CBLB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CBLB Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP667545MO CSB-EP667545MO CSB-BP667545MO CSB-MP667545MO CSB-EP667545MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase CBL-B (Cblb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CBLB Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP715671XBF CSB-EP715671XBF CSB-BP715671XBF CSB-MP715671XBF CSB-EP715671XBF-B |
Recombinant Xenopus tropicalis E3 ubiquitin-protein ligase CBL-B (cblb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CBLB Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP814329RA CSB-EP814329RA CSB-BP814329RA CSB-MP814329RA CSB-EP814329RA-B |
Recombinant Rat E3 ubiquitin-protein ligase CBL-B (Cblb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |