Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

1. L-type amino acid transporter 1 (LAT1) inhibitor, BCH reduces the phosphorylation of mechanistic target of rapamycin kinase (mTOR) downstream target eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Silencing eIF4E neutralized the stimulation of interleukin-17 on LAT1. PMID: 29198077
2. Using an mTORspecific signalling pathway phospho array we revealed that NVPBEZ235 significantly decreased phosphorylation of 4EBP1 (Thr70), the downstream target of mTORC1. PMID: 29845289
3. High p-4E-BP1 expression was significantly associated with lymphovascular invasion (LVI) (p=0.003), perineural invasion (PNI) (p=0.001), tumor stage (p=0.024), nodal stage (p=0.000), metastatic status (p=0.027), and disease stage (p=0.001). PMID: 28242042
4. Numerous protein kinases can be responsible for mTOR independent 4E-BP1 phosphorylation in cancer. (Review) PMID: 28427795
5. PI3K kinase activity is necessary for maintaining 4E-BP1 stability. Our results also suggest 4E-BP1 a novel biological role of regulating cell cycle G2 checkpoint in responding to IR stress in association with controlling CHK2 phosphorylation PMID: 28539821
6. Findings suggest that mitotic CDK1-directed phosphorylation of delta-4E-BP1 may yield a gain of function, distinct from translation regulation, that may be important in tumorigenesis and mitotic centrosome function. PMID: 27402756
7. p4EBP1 was independently predictive for pathologic complete response in PIK3CA wild-type tumors. PMID: 26758558
8. Data show that 4EGI-1 compound induced apoptosis in nasopharyngeal carcinoma cells through the death receptor 5 (DR5) on 4E-BP1 dephosphorylation exerting positive influence on their anti-tumor activities. PMID: 26942880
9. p4EBP1 overexpression was predominant in patients with metastasis to the regional lymph nodes in colorectal cancer. Moderate/high expression of p4EBP1 protein was significantly associated with adverse overall survival (OS) in patients. PMID: 28339030
10. Rotterlin inhibits mTORC1 and 4EBP1 activity in melanoma cells, inhibiting protein synthesis and promoting cell death. PMID: 27343979
11. p-4E-BP1 is more highly expressed in early gastric cancers than in advanced ones, and has limited potential as an independent prognostic biomarker in patients with gastric cancer. PMID: 25661069
12. this study shows that anticancer activity of perillyl alcohol is mediated via inhibition of 4E-BP1 signaling PMID: 27394002
13. 4EBP1 may serve as a funnel factor that converge the upstream proliferative oncogenic signals. PMID: 27026382
14. Increased expression of miR-125a is associated with invasion and migration in ovarian cancer. PMID: 26646586
15. 4E-BP1 was shown to be phosphorylated by other kinases besides mTOR, and overexpression of 4E-BP1 was found in different human carcinomas. (Review) PMID: 26901143
16. Twist1 is correlated with p-4E-BP1 in predicting the prognostic outcome of NSCLC. PMID: 26360779
17. Increased 4EBP1 abundance was a common feature in prostate cancer patients who had been treated with the PI3K pathway inhibitor BKM120; thus, 4EBP1 may be associated with drug resistance in human tumors PMID: 26577921
18. results suggest that respiratory syncytial virus is a virus that still contains unknown mechanisms involved in the translation of their mRNAs through the alteration or modification of some translation factors, such as 4EBP1, possibly to favor its replicative PMID: 26305094
19. eIF4E binding protein 1 expression has a role in clinical survival outcomes in colorectal cancer PMID: 26204490
20. It was concluded that over-activation of the mTORC1/4E-BP1/p21 pathway is a frequent and clinically relevant alteration in head and neck squamous cell carcinomas. PMID: 26832959
21. The aim of the present work was to probe the conformation of the intrinsically disordered protein 4E-BP1 in the native and partly folded states by limited proteolysis and to reveal regions with a high propensity to form an ordered structure. PMID: 24122746
22. Taken together, these results highlight the potential dependence of eIF4G overexpression and 4E-BP1 phosphorylation in CLL survival. PMID: 25999352
23. Results suggest that blocking both the mTOR kinase downstream targets 4E-BP1 protein and p70 S6 kinase 1, but not p70 S6 kinase 1 alone, prevents the migration of retinal pigment epithelium (RPE) cells. PMID: 26427479
24. phosphorylation site affected the prognostic significance of 4EBP1 in non-small cell lung cancer. PMID: 26097581
25. 4EBP1 is not completely unstructured, but contains a pre-structured helix. PMID: 25431930
26. inactivation of 4E-BP1 using Ku-0063794 may be a promising novel approach for muscle-invasive bladder cancer PMID: 25618298
27. mTORC1 regulates cell adhesion through S6K1 and 4E-BP1 pathways, but mTORC2 regulates cell adhesion via Akt-independent mechanism PMID: 25762619
28. mitotic cap-dependent translation is generally sustained during mitosis by CDK1 phosphorylation of 4E-BP1 even under conditions of reduced mTOR signaling PMID: 25883264
29. In colorectal carcinoma, total expression levels of 4E-BP1 increased only in the premalignant state of the disease and decreased (but highly phosphorylated or inactivated) or abolished upon malignancy. PMID: 25755728
30. Results show that high expression of p70S6K and 4EBP1 proteins may act as valuable independent biomarkers to predict poor prognosis of nasopharyngeal carcinoma patients. PMID: 25165983
31. the C-terminal extension (motif 3) is critical to 4E-BP1-mediated cell cycle arrest and it partially overlaps with the binding site of 4EGI-1 PMID: 26170285
32. Effect of temperature on the conformation of natively unfolded protein 4E-BP1 in aqueous and mixed solutions containing trifluoroethanol and hexafluoroisopropanol. PMID: 25503819
33. ShcA drives breast tumor growth and angiogenesis in vivo in a 4E-BP-dependent manner PMID: 24837366
34. Studied conditions that increase the sensitivity of cancer cells to MK-2206. and found reduction by salinomycin of Akt and downregulation of pAkt, pGSk3beta, pTSC2, and p4EBP1 by cotreatment with MK-2206. PMID: 25114899
35. Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway. PMID: 25659153
36. certain Akt/mTOR/4E-BP1 pathway signals could be novel therapeutic targets for Merkel cell carcinomas regardless of Merkel cell polyomavirus infection status PMID: 25466966
37. 4E-BP1 is a trigger for parthenolide -induced autophagy PMID: 25482447
38. Acquired drug resistance to antineoplastic agents is regulated in part by 4E-BP1. PMID: 24354477
39. Results show that loss-of-function of TBC1D7 protein was associated with an increase in the phosphorylation of 4EBP1, a direct downstream target of mTORC1. PMID: 24515783
40. Overexpression of phosphorylated 4E-binding protein 1 is associated with lymph node metastasis in hilar cholangiocarcinoma PMID: 24706262
41. The tumor marker eRF3B can change the cell cycle and influence the phosphorylation status of 4E-BP1. PMID: 24466059
42. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer. PMID: 24131622
43. p-4E-BP1 may have a role in response to the mTOR inhibitors and progression-free survival PMID: 24307346
44. mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs). PMID: 24206664
45. rapalog-activated MNK1 signaling promotes glioma growth through regulation of 4EBP1; there is a molecular cross-talk between the mTORC1 and MNK1 pathways PMID: 24401275
46. overexpression of 4EBP1, p70S6K, Akt1 or Akt2 could promote the Coxsackievirus B3-induced apoptosis. PMID: 24030155
47. Our results suggest that long-term repeated viral delivery of 4E-BP1 may provide a useful tool for designing lung cancer treatment. PMID: 23640516
48. The results indicate mTOR-independent phosphorylation of S6K1 and 4E-BP1 and suggest MEK/ERK/RSK1-dependent phosphorylation of eIF4B during skeletal muscle contraction. PMID: 23707523
49. study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1. PMID: 23814053
50. Data therefore suggest that HIF-1alpha contributes to 4E-BP1 gene expression under different conditions. PMID: 23175522

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HGNC: 3288

OMIM: 602223

KEGG: hsa:1978

STRING: 9606.ENSP00000340691

UniGene: Hs.411641