Recombinant Human Growth arrest-specific protein 6(GAS6),Yeast

Code CSB-YP619872HU
Size
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Product Details

Purity >85% (SDS-PAGE)
Target Names GAS6
Uniprot No. Q14393
Alternative Names AXL receptor tyrosine kinase ligand; AXL stimulatory factor; AXLLG; AXS F; AXSF; DKFZp666G247; FLJ34709; Gas 6; GAS-6; Gas6; GAS6_HUMAN; Growth arrest specific 6; Growth arrest-specific protein 6; Growth-arrest-specific protein 6; Growth-arrest-specific protein 6 precursor
Species Homo sapiens (Human)
Source Yeast
Expression Region 31-678
Target Protein Sequence ALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFENDPETDYFYPRYLDCINKYGSPYTKNSGFATCVQNLPDQCTPNPCDRKGTQACQDLMGNFFCLCKAGWGGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFELSSDGRTCQDIDECADSEACGEARCKNLPGSYSCLCDEGFAYSSQEKACRDVDECLQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTCEDILPCVPFSVAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLVAEFDFRTFDPEGILLFAGGHQDSTWIVLALRAGRLELQLRYNGVGRVTSSGPVINHGMWQTISVEELARNLVIKVNRDAVMKIAVAGDLFQPERGLYHLNLTVGGIPFHEKDLVQPINPRLDGCMRSWNWLNGEDTTIQETVKVNTRMQCFSVTERGSFYPGSGFAFYSLDYMRTPLDVGTESTWEVEVVAHIRPAADTGVLFALWAPDLRAVPLSVALVDYHSTKKLKKQLVVLAVEHTALALMEIKVCDGQEHVVTVSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPDVPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Protein Length Full Length of Mature Protein
Tag Info N-terminal His-tagged
Tag-Free
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Background

Function
(From Uniprot)
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Gene References into Functions
  1. Growth Arrest-Specific 6(GAS6) levels increased significantly after vitamin K1 prophylaxis in preterm newborns but not in term infants PMID: 28335649
  2. Higher levels of Gas6 in plasma are obviously correlated with acute lung injury (ALI) development. An early increase in the plasma Gas6 level suggests that endothelial injury is a key link in the pathogenesis of ALI. PMID: 29176262
  3. This study demonstrates that motility behavior of AXL-expressing tumor cells can be elicited by Gas6-bearing apoptotic bodies generated from tumor treatment with therapeutics that produce killing of a portion of the tumor cells present but not all, hence generating potentially problematic invasive and metastatic behavior of the surviving tumor cells PMID: 28923840
  4. Self-sustaining cells are characterized by excessive GAS6 secretion and TAM-PDK-RSK-mTOR pathway activation. PMID: 28675785
  5. The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6/Axl pathway and its downstream phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways. PMID: 28627676
  6. TWIST1, in part via GAS6 and L1CAM, led to higher expression and activation of Akt upon cisplatin treatment, and inhibition of Akt activation sensitized cells to cisplatin. PMID: 27876874
  7. Gas6 bound to the fiber proteins of adenovirus and suppressed IFN beta production. PMID: 29288958
  8. Protein S and Gas6 mediates phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase Mer to phosphatidylserine exposed on infected cells. PMID: 29304470
  9. A critical role for GAS6 in epithelial cells in maintaining oral homeostasis. PMID: 28049839
  10. AXL is the only relevant Zika virus entry cofactor expressed on fetal endothelial cells, and that when produced in mammalian cells, only Zika virus, but not West Nile virus or dengue virus, can use AXL, because it more efficiently binds Gas6. PMID: 28167751
  11. The plasma concentrations of Gas6 and Axl are lowered in rheumatoid arthritis patients. PMID: 24702788
  12. Suppression of AXL by shRNA and inhibitor prolonged survival of chronic myelogenous leukemia (CML) mice and reduced the growth of leukemia stem cells ( LSCs) in mice. Gas6/AXL ligation stabilizes beta-catenin in an AKT-dependent fashion in human CML CD34(+) cells. Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs PMID: 27852702
  13. AXL+ and GAS6+ expression is relevant to a poor prognosis in resected lung adenocarcinoma (AD)patients at stage I. AXL/GAS6 might serve as crucial predictive and prognostic biomarkers and targets to identify individuals at high risk of post-operative death. PMID: 28440492
  14. Taken together, our data indicate that elevated plasma Gas6 levels is associated with the severity of disease during HTNV infection in humans, suggesting that Gas6 may play an important role by binding with Tyro3 on monocytes. PMID: 28537534
  15. Study detected an inverse correlation between CSF Gas6 levels at Alzheimer's disease (AD) diagnosis and both disease duration and decrease in the MMSE score two years later. Conversely,no correlation was found between CSF Gas6 and both AD biomarkers and years of formal schooling. Results suggest that upregulation of CSF Gas6 may be part of a defensive response aimed at counteracting AD progression. PMID: 27636849
  16. Upon chemotherapy macrophages increase Gas6 synthesis, which significantly attenuates the cytotoxic effect of 5-FU chemotherapy on colorectal cancer cells. PMID: 27486820
  17. These results show that TYRO3, AXL and GAS6 are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients. PMID: 29024938
  18. these data suggest that endogenous GAS6 and Mer receptor signaling contribute to the establishment of prostate cancer stem cells in the bone marrow microenvironment PMID: 27028863
  19. The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer PMID: 27703030
  20. The expression of AXL was positively associated with GAS6 expression (P < 0.001), and tumor differentiation (P = 0.014) in advanced NSCLC with metastases. AXL expression displayed no association with gender, age, smoking history, pathology, T stage, N stage, CEA, and LDH. PMID: 28551766
  21. These results demonstrate that Gas6/Axl axis confers aggressiveness in breast cancer. PMID: 27279912
  22. Our data suggest that a TT genotype at +1332C/T polymorphism might be associated with decreased risk for preeclampsia, but the 834+7G/A polymorphism is not associated with the disorder, in the Chinese population. PMID: 28242471
  23. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies PMID: 27893463
  24. In conclusion, our study shows that SNPsrs8191974 and rs2028299 of the Gas6 are significantly associated with type 2 diabetes mellitus (T2DM) in the Chinese population PMID: 28399188
  25. High GAS6 expression is associated with Multiple Myeloma. PMID: 28154173
  26. Data show that the variant growth arrest specific 6 (GAS6) +1332 T allele is associated with a decreased risk for severe preeclampsia in a South West Han Chinese population, but the 834+7G/A polymorphism has no effect on the severe preeclampsia. PMID: 28186592
  27. Gas6 plasma level within 24 hours of ICU admission may predicts in-ICU mortality in patients with sepsis PMID: 27788141
  28. In this paper, we review the biology of the Gas6/Tyro3, Axl, and MerTK(collectively named TAM system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis . PMID: 27801848
  29. serum testosterone and GAS6 levels were positively associated in male patients with coronary heart disease PMID: 26924277
  30. investigation of the prognostic values of stromal NK cells and Gas6 in triple negative breast cancer (TNBC), and to eventually establish a prognostic risk model for patients with TNBC PMID: 27145494
  31. CONCLUSIONS: Our results suggest that GAS6 c.834 + 7G> A polymorphism may have a pivotal role in the pathogenesis of preeclampsia (PE) suggesting that the A allele has a protective role for PE. PMID: 25915719
  32. Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses. PMID: 27006397
  33. High expression of Gas6 correlated with Upper Tract Urothelial Carcinoma. PMID: 26350366
  34. Gas6 and Axl serum levels increase in parallel to chronic liver disease progression inactivation. PMID: 25908269
  35. GAS6 intron 8 c.834 + 7G > A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy. PMID: 25869052
  36. decreased plasma Gas6 concentration and labial salivary gland expression were associated with primary Sjogren syndrome(pSS); Gas6 may represent a novel independent risk factor for pSS, with a potential role in salivary gland inflammation and dysfunction PMID: 26445266
  37. Gas6 increases the metastatic capacity of oral squamous cell carcinoma(OSCC) cells and serum Gas6 could be a candidate biomarker for diagnostic and prognostic use in OSCC patients. PMID: 26207647
  38. Gas6 gene variants are associated with IR, although their effects on subsequent progression to T2D were minimal in this prospective Asian cohort PMID: 26284522
  39. Data shoed increased GAS6 and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification. PMID: 25957430
  40. Gas6-induced Axl signaling is a critical driver of pancreatic cancer progression. PMID: 26206560
  41. genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
  42. Suggest an association between low plasma GAS6 levels and conventional cardiometabolic risk factors in psoriasis. PMID: 25752901
  43. a protective role for AA Gas6 variant in type 2 diabetic patients may be concluded PMID: 26415371
  44. These results suggest that plasma Gas6 is associated with sex hormones in both pre- and postmenopausal women PMID: 24676757
  45. The present study highlights that the GAS6/ProS-TAM system correlates in several ways with disease activity in systemic lupus erythematosus PMID: 23497733
  46. Inhibition of the Gas6 receptor Mer or therapeutic targeting of Gas6 by warfarin is a promising strategy for the treatment of multiple myeloma. PMID: 25102945
  47. HIF-1 and HIF-2 directly activate the expression of AXL and GAS6/AXL signaling uses lateral activation of the met proto-oncogene (MET) through SRC proto-oncogene nonreceptor tyrosine kinase to maximize cellular invasion. PMID: 25187556
  48. Plasma levels of growth arrest specific protein 6 are increased in idiopathic recurrent pregnancy loss PMID: 24899617
  49. plasma levels associated with albuminuria in patients with type 2 diabetes PMID: 24512357
  50. Gas6 could play a potential role in the pathogenesis of adult-onset Still's disease PMID: 24770797

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Subcellular Location Secreted
Tissue Specificity Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.
Database Links

HGNC: 4168

OMIM: 600441

KEGG: hsa:2621

UniGene: Hs.646346

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