Recombinant Human Integrin alpha-2(ITGA2) ,partial

Code CSB-EP011864HU
Size US$1726
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names ITGA2
Uniprot No. P17301
Research Area Signal Transduction
Alternative Names BR; CD 49b; CD49 antigen like family member B; CD49 antigen-like family member B; CD49b; CD49b antigen; Collagen receptor; DX5; Glycoprotein Ia deficiency included; GP Ia; GP Ia deficiency; included; GPIa; HPA 5 included; HPA5 included; Human platelet alloantigen system 5; Integrin alpha 2; Integrin alpha II; Integrin alpha-2; Integrin; alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor); ITA2_HUMAN; ITGA2; Platelet alloantigen Br(a); included; Platelet antigen Br; Platelet glycoprotein GPIa; Platelet glycoprotein Ia; Platelet glycoprotein Ia/IIa; Platelet membrane glycoprotein Ia; Platelet receptor for collagen; deficiency of; included; Very late activation protein 2 receptor alpha 2 subunit; VLA 2 alpha chain; VLA 2; VLA 2 subunit alpha; VLA-2 subunit alpha; VLA2; VLA2 receptor alpha 2 subunit; VLAA2
Species Homo sapiens (Human)
Source E.coli
Expression Region 188-365aa
Target Protein Sequence WDAVKNFLEKFVQGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYARKYAYSAASGGRRSATKVMVVVTDGESHDGSMLKAVIDQCNHDNILRFGIAVLGYLNRNALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIE
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 35.6kDa
Protein Length Partial
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.; FUNCTION
Gene References into Functions
  1. Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics PMID: 29236307
  2. Carriage of a combination of mutant alleles in multiple genes including ITGB3+CYP2C19*2 or CYP2C19*2 + ITGA2 or CYP2C19*2 are possible predictors of CVE in patients after CABG PMID: 29461866
  3. Studied the association between integrin subunit alpha 2 (GPIa) and prostaglandin-endoperoxide synthase 2 (COX-2) genetic polymorphisms in Chinese ishemic stroke patients with or without aspirin resistance. PMID: 28948649
  4. GP Ia C807T polymorphism may contribute to ischemic stroke development in the Chinese population (meta-analysis). PMID: 29208186
  5. The authors identified a cell surface marker, ITGA2, which marks a proliferative trophoblast progenitor compartment in the first trimester placenta that is regulated by NOTCH signalling and exhibits unique expression characteristics. PMID: 29540503
  6. discovered that OLFM4, CD11b, and ITGA2 are proteins that are overexpressed in both primary colon tumors and liver metastasis. These are colon cancer biomarkers with autoantigenic properties. PMID: 28669815
  7. This study demonstrated that the transactivation of FOXL2 driven by interactions between HMGA2 and pRb might exert critical effects on the metastases and EMT of chemoresistant gastric cancer. Blocking the HMGA2-FOXL2-ITGA2 pathway could serve as a new strategy for gastric cancer treatment. PMID: 28119367
  8. The GpIa-C807T and GpIIIa-PlA1/PlA2 polymorphisms and more pronouncedly their combination are associated with increased risk of spontaneous abortions. PMID: 27405521
  9. The allele combination of CGC from hOGG1, ITGA2 and XPD polymorphisms was significantly associated with increased odds of nasopharyngeal carcinoma. PMID: 29121049
  10. blood platelets have a role in amyloid-beta aggregation in cerebral vessels through integrin alphaIIbbeta3-induced outside-in signaling and clusterin release PMID: 27221710
  11. Exposure to magnesium ions facilitated hBMSC proliferation via integrin alpha2 and alpha3 expression and partly promoted differentiation into osteoblasts via the alteration of ALP expression and activity PMID: 24616281
  12. The synonymous common variant, GPIA rs1126643, increases the long-term adverse events risk of CABG by augmenting GPIa protein expression and enhancing platelet aggregation function. PMID: 27881421
  13. we found a significant cumulative contribution of the genetic heterogeneity of glycoproteins Ia and IIIa and platelet-endothelial cell adhesion molecule-1 and P-Selectin genes in the risk of recurrent IVF-ET failures. The coexistence of these SNPs was associated with increased IVF-ET failure risk and the more polymorphic alleles or genotypes were present the higher the risk of IVF-ET failure, especially for younger women PMID: 28388872
  14. Meta-analysis found that glycoprotein Ia C807T T allele or the TT genotype, the Ser-allele of HPA-3 and B allele of glycoprotein Ibalpha variable number tandem repeat polymorphisms were associated with increased risk for ischemic stroke. PMID: 28004990
  15. Data indicate no association of maternal or fetal ITGA2 C807T SNP, ITGB3 T1565C SNP, PECAM1 CTG - GTG and SELP A/C polymorphisms with fetal growth restriction (FGR). PMID: 28358707
  16. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects. PMID: 27019315
  17. A sulfonamide-type small-molecule inhibitor of alpha2beta1 integrin decreased average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C. PMID: 26556301
  18. Platelet GP Ia 807C/T polymorphism could be a protective factor of for cerebral hemorrhage in the Chinese population. PMID: 26134877
  19. high miR-128 expression suppressed osteosarcoma cell migration, invasion, and EMT development through targeting ITGA2, which may be recommended as a therapeutic target for osteosarcoma. PMID: 26700675
  20. Study identified a novel RANKL function in the promotion of cell adhesion to type I collagen through the RANKL-NF-kappa B-integrin alpha 2 pathway and found integrin alpha2 and RANKL up-regulated in non small cell lung carcinoma. PMID: 27009236
  21. Recently, new clinical observations of genetic diseases provided evidence bringing new data on the role of alphaIIbbeta3 integrin in defective megakaryopoiesis. [review] PMID: 27011248
  22. High ITGA2 expression is associated with cervical cancer. PMID: 26758421
  23. PDI-mediated disulfide bond exchange plays a pivotal role in the post-ligation phase of alphaIIbbeta3-mediated adhesion to fibrinogen, while this step in alphavbeta3-mediated adhesion is independent of disulfide exchange PMID: 26514956
  24. Our results indicate that GpIa-807T and GpIIIa-PlA2 may be susceptibility alleles for in vitro fertilization implantation failure. PMID: 25643034
  25. PFL-mediated downregulation of integrin and EGFR contributes to the inhibition of tumor growth in vitro and in vivo. This novel anti-cancer mechanism of PFL suggests that this lectin would be useful as an anti-cancer drug or an adjuvant for other drugs. PMID: 26850110
  26. HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I. PMID: 26051322
  27. The Glycoprotein Ia C807T polymorphism might be a risk factor for the development and relapse of Acute Coronary Syndrome PMID: 26304618
  28. Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b and LAG-3 (CD223) on CD14(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females. PMID: 26927558
  29. Integrin alpha 2 and alpha 4 Yxxphi motifs interact with the endocytic clathrin adaptor, AP2 complex. PMID: 26779610
  30. Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. PMID: 26258411
  31. A highly bone metastatic RANKL-overexpressing prostate cancer cell line, LNCaP(RANKL)used as a model to study increased adhesion of prostate cancer (PCa) cells to collagens and found 3-D suspension culture and in vivo PCa tumor growth restore AR through downregulation of AP-4, enhancing integrin alpha2 expression and adhesion to ColI which is rich in bone matrices. PMID: 25200184
  32. diabetic retinopathy is associated with ITGA2 and ITGB3 PlA1/A2 polymorphisms (Meta-Analysis) PMID: 24979111
  33. This study shows that osteoblastic differentiation is improved on 3D scaffolds with submicron-scale texture and is mediated by integrin alpha2beta1. PMID: 25203434
  34. Current review discusses the mechanisms by which integrin is activated and subsequently deactivated by focusing on its structure-function relationship PMID: 26152212
  35. Polymorphism of HPA- 5 is probably a risk factor for carotid atherosclerosis complicating T2DM. PMID: 25966234
  36. blockade of alpha2beta1 integrin with a neutralizing mAb inhibited IL-7-induced bone loss and osteoclast numbers by reducing Th17 cell numbers in the bone marrow PMID: 26408663
  37. EZH2-silenced cells the signaling activity of the de-repressed ITGalpha2 is able to increase cofilin phosphorylation, which in turn reduces cell migration. PMID: 25549357
  38. The Integrin alpha2 2 gene C807T polymorphism may be a susceptible predictor of the risk of ischemic stroke. PMID: 24397542
  39. CD34 and CD49b are cell surface markers that can be used to enrich a subpopulation of leiomyoma cells possessing stem/progenitor cell properties. PMID: 25658015
  40. alpha2beta1 integrin gene expression levels were increased significantly in keloid fibroblasts under tension compared to normal fibroblasts under tension. Knockdown of Integrin A2B1 reduced cell proliferation in fibroblasts under tension. PMID: 25046655
  41. Carbohydrate-to-carbohydrate interactions between alpha2,3-linked sialic acids on alpha2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells. PMID: 25137483
  42. The alphaII b tail sequences distal of GFFKR participate in talin-mediated inside-out alphaII b beta3 activation through its steric clashes with beta3 -bound talin PMID: 24837519
  43. The alpha2beta1 integrin mediates T-acute lymphoblastic leukemia cell migration through collagen in ERK and p38 MAPKs-dependent manner PMID: 24880062
  44. These results reveal betaig-h3 enhances the metastasis potentials of human osteosarcoma cells via integrin alpha2beta1-mediated PI3K/AKT signal pathways. PMID: 24595049
  45. ITGA2 is downregulated 39-fold by silencing of laeverin in trophoblasts, reducing cell migration and invasion. PMID: 24959655
  46. Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543 PMID: 24958723
  47. ITGA2 +807 gene polymorphism is not associated with susceptibility to CsA-induced GO. PMID: 24581850
  48. glycoprotein Ia C807T polymorphism is associated with idiopathic sudden hearing loss. PMID: 24466284
  49. It plays a role in regulation of leukocyte migration to a site of inflammation. PMID: 24850451
  50. Usage of internal N-acetylneuraminic acids and alpha2beta1 integrin by Wa rotavirus was at least partially additive. PMID: 24501414
  51. Integrin alpha2beta1 and integrin alpha3beta1 suppress anoikis in undifferentiated cells. PMID: 24289209
  52. Integrin alpha2 beta1 and EGFR cooperatively promote higher invasiveness of ionizing radiation - survived lung cancer cells, mediated in part by the PI3K/Akt signaling pathway, and might serve as alternative targets in combination with radiotherapy. PMID: 23951036
  53. study reports a functional and structural characterisation of the alpha2 I domain E318W mutant; E318W I domain A interacts with 2 collagen chains similar to wild-type I domain (high-affinity mode; E318W I domain B makes favorable interactions with only one collagen chain (low-affinity mode) PMID: 23922814
  54. alpha2beta1 integrin is expressed on synovial Th17 cells from RA patients. Its ligation with collagen costimulated IL-17 production by polarized Th17 cells by enhancing the expression of RORc through ERK & PI3K/AKT. PMID: 24244022
  55. HPA-5 typing discrepancy reveals an Ile503Leu substitution in platelet GPIa (alpha2 integrin). PMID: 23368983
  56. results suggest integrin alpha2 promotes osteoblast proliferation PMID: 23638215
  57. PRL-3 plays a critical role in ovarian cancer tumorigenicity and maintaining the malignant phenotype. PRL-3 may inhibit c-fos transcriptional regulation of integrin alpha2 signaling. PMID: 23418787
  58. show that human PSG1 binds alphaIIbbeta3 and inhibits the platelet - fibrinogen interaction. Unexpectedly, however, the KGD is not critical as multiple PSG1 domains independently bind and inhibit alphaIIbbeta3 function PMID: 23469002
  59. data demonstrate that alpha2beta1 protein was elevated in PCa skeletal metastases compared to either PCa primary lesions or soft tissue metastases suggesting that alpha2beta1 contributes to the selective metastasis to the bone. PMID: 23242739
  60. Integrin alpha2 is identified to be a novel EZH2 target by chromatin immunoprecipitation and short hairpin RNA analysis. PMID: 23116973
  61. Domain V of perlecan, a known alpha2 integrin ligand, inhibits brain amyloid-beta neurotoxicity in an alpha2 integrin-dependent manner. PMID: 21126803
  62. An integrin alpha2 C807T polymorphism is associated with an increased risk of P. vivax-induced severe thrombocytopenia. PMID: 23249684
  63. Interaction between integrin alpha2beta1 and collagen type I takes place prior to collagen receptor activation. PMID: 23132859
  64. study proves that flavocetin-A, which has long been known as a GPIb inhibitor, efficiently targets alpha2beta1 integrin and thus blocks collagen-induced platelet activation PMID: 23204528
  65. a novel virus- and clustering-specific pathway that diverts alpha2beta1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route PMID: 22160595
  66. Patients with idiopathic sudden sensorineural hearing loss had a higher prevalence of the 807T thrombophilic polymorphism of ITGA2. There was a significant correlation between the 807TT homozygous genotype and a low probability of recovery. PMID: 22948415
  67. findings suggest that there is no role of GPIa C807T polymorphisms in the development of young first-ever ischemic stroke in Chinese Han Population PMID: 23161041
  68. Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human beta1 and alpha2 integrin. PMID: 22590584
  69. Platelets bearing even one minor allele of integrin alpha2 534K show attenuated adhesion to decorin but not to collagen I. PMID: 22133774
  70. Data suggest that monoclonal antibody J19 is a potentially powerful tool for both studies on alpha(4)beta(7) activation mechanism and development of novel therapeutics targeting the activated lymphocyte expressing high affinity alpha(4)beta(7). PMID: 22418441
  71. This evidence indicates that host cell ITGA2 might be involved in interacting with Cryptosporidium during infection. PMID: 22354032
  72. Single-nucleotide polymorphisms in ITAG2 is associated with chronic kidney disease in Type 2 diabetes. PMID: 21765051
  73. Expression of laminin beta1 and integrin alpha2 is elevated in the anterior temporal neocortex tissue from patients with intractable epilepsy. PMID: 21370991
  74. Inflammation can up-regulate the expressions of Integrin alpha2beta1 and CD133 in benign prostatic hyperplasia tissue. PMID: 22049795
  75. Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase). PMID: 21787362
  76. Findings do not support the influence of the IRGA2807T allele in the development of retinopathy in type 2 diabetes. PMID: 21632096
  77. Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles. PMID: 22015659
  78. Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators. PMID: 21850018
  79. CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands PMID: 21743959
  80. The disturbance of alpha2beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation. PMID: 21796158
  81. Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces. PMID: 21658756
  82. A vicinal thiol-containing population of alphaIIbbeta3 provides redox sensitive sites for regulation of alphaIIbbeta3. PMID: 21645227
  83. data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88 PMID: 21652699
  84. Rapid initiation of collagen-induced platelet aggregation may be associated with the platelet membrane GPIa T807 allele, which may be important in unstable angina pectoris pathogenesis. PMID: 21672359
  85. Data suggest that the ITGA2 gene C807T polymorphism may be associated with an increased risk of gastric cancer, differentiation and invasion of gastric cancer. PMID: 21734795
  86. endorepellin requires both the alpha2beta1 integrin and VEGFR2 for its angiostatic activity PMID: 21596751
  87. The extracellular matrix rigidity affects the osteogenic outcome of mesenchymal stem cells through mechanotransduction events that are mediated by alpha(2)-integrin. PMID: 20939067
  88. molecular forces of the alpha2beta1 integrin-collagen interaction PMID: 21262375
  89. Single nucleotide polymorphisms of integrin alpha-2 gene is not associated with colorectal cancer. PMID: 21508388
  90. Polymorphisms in IL5RA, LPL, ITGA2 and NOS3 genes were independently associated with ischemic stroke in Chinese diabetic population. PMID: 21193198
  91. Results suggest a novel mechanism for pathogen entry into host cells as well as a new function for C1q- alpha2beta1 integrin interactions. PMID: 21134100
  92. a mutation in alphaIIbbeta3 integrin may have a role in Glanzmann thrombasthenia [case report] PMID: 20492470
  93. alpha2beta1 integrin functionally inhibits breast tumor metastasis, and alpha2 expression may serve as an important biomarker of metastatic potential and patient survival PMID: 21135504
  94. alpha2beta1 integrin may be a major regulatory molecule in Th17 cell functions. PMID: 20806289
  95. Single-nucleotide polymorphism in ITGA2 is associated with coronary atherosclerosis. PMID: 20485444
  96. Platelet membrane glycoprotein Ia variations may have an important impact on aspirin resistance. PMID: 18231737
  97. The increase in human platelet antigen, HPA-5b allelic frequency in Hepatitis C infection may indicate a possible association between HCV infection and HPAs. PMID: 19235843
  98. Polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease could significantly impact platelet function. PMID: 20336352
  99. The syndecan- and alpha2beta1 integrin-binding peptides synergistically affect cells and accelerate cell adhesion. PMID: 20598296
  100. the 807T allele of GP Ia and the PlA2 allele of GP IIIa, and specially its combination confer an additional risk for development of carotid atherosclerosis and arterial thrombosis in type 2 diabetes PMID: 20076847

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Integrin alpha chain family
Database Links

HGNC: 6137

OMIM: 192974

KEGG: hsa:3673

STRING: 9606.ENSP00000296585

UniGene: Hs.482077

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