Recombinant Human Macrophage mannose receptor 1(MRC1),partial

Code CSB-EP014783HUa0
Size US$1726
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014783HUa0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MRC1.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014783HUa0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MRC1.
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Product Details

Purity Greater than 85% as determined by SDS-PAGE.
Target Names MRC1
Uniprot No. P22897
Research Area Immunology
Alternative Names bA541I19.1; C type lectin domain family 13 member D; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor 1; Macrophage mannose receptor 1 like protein 1; Macrophage mannose receptor; Mannose receptor C type 1; Mannose receptor C type 1 like 1; MMR; MRC 1; MRC1; MRC1_HUMAN; MRC1L1; OTTHUMP00000045206
Species Homo sapiens (Human)
Source E.coli
Expression Region 655-1213aa
Target Protein Sequence RTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHCNESFYFLCK
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 69.9 kDa
Protein Length Partial
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; FUNCTION
Gene References into Functions
  1. Structural Insights into the pH-dependent conformational change and collagen recognition of the human mannose receptor have been reported. PMID: 29225077
  2. no significant difference between our population of Egyptian SCD cases and controls regarding CD209 A>G polymorphism. Infections occurred more frequently among the heterozygous genotype (AG) and homozygous genotype (GG) patients. PMID: 29100978
  3. A combination of CD68/CD206 density and HBV-positivity improves further predictive value for post-operative recurrence of hepatocellular carcinoma (HCC) . Quantification of CD68/CD206 macrophages and their distribution can be exploited for better postsurgical management of HCC patients. PMID: 28656201
  4. The results showed that the small dense LDL particles reduce the MRC1 gene expression levels in the differentiated M2 macrophages from patients with coronary artery disease. Furthermore, they had high inflammatory capacity for the secretion of histamine. PMID: 28059035
  5. Soluble CD206 plasma levels in rheumatoid arthritis reflect decrease in disease activity. PMID: 28598681
  6. Loss of antral CD206-positive anti-inflammatory macrophages is a key feature in human gastroparesis and it is associates with interstitial cells of Cajal loss. PMID: 28066953
  7. The effect of LPS in the expression of CD163 and CD206 on monocytes is not reverted in LPS tolerant cells, and the inhibition of inflammatory cytokines in tolerant cells is not related with modulation of these receptors PMID: 26352275
  8. regulatory effect of the mannose receptor (MR) was mediated by a direct interaction with CD45 on the T cell, inhibiting its phosphatase activity, which resulted in up-regulation of CTLA-4 and the induction of T-cell tolerance. Inhibition of CD45 prevented expression of B-cell lymphoma 6 (Bcl-6), a transcriptional inhibitor that directly bound the CTLA-4 promoter and regulated its activity PMID: 27601670
  9. 1,25(OH)2D3 upregulates mannose receptor expression and enhances the monocyte/macrophage phagocytic potential in pulmonary tuberculosis. PMID: 27449998
  10. Peritoneal dendritic cellss in endometriosis tissue express high levels of MR, which promotes phagocytosis of dead endometrial cells and thereby contributes to the etiology of endometriosis. PMID: 27793384
  11. Mannose Receptor and CLEC5A on Macrophage first attracts the Dengue Virus with high avidity, and the virus concurrently interacts with CLEC5A in close proximity to form a multivalent hetero-complex and facilitate CLEC5A-mediated signal transduction. Dengue Virus Infection Is through a Cooperative Interaction between a Mannose Receptor and CLEC5A on Macrophage as a Multivalent Hetero-Complex. PMID: 27832191
  12. Our work demonstrates a key role for MR in the modulation of the TLR4-AhR-IDO axis, which has a significant effect on DC behavior and the development of immune responses against allergens. PMID: 26703454
  13. MRC1 and S100A9 may contribute to the determination of the mechanisms and screening involved in CRC. PMID: 26682511
  14. Findings show that CD206 was highly expressed in the hepatocellular carcinoma (HCC) tissues and indicate that CD206 is a potential biomarker for predicting HCC prognosis. PMID: 26352004
  15. Data show that umbilical cord-derived mesenchymal stem cells (UCMSCs) transplantation promoted the expression of CD206 antigen and increased phagocytic activity of macrophages through interleukin-6 (IL-6) in systemic lupus erythematosus (SLE) patients. PMID: 26209923
  16. Data indicate that mannose receptor (CD206) is a major binding receptor for gamma-tilmanocept. PMID: 26202986
  17. CD206 is a novel biomarker of alternative macrophage activation and treatment outcome in multiple myeloma. PMID: 26169445
  18. The genome wide significant association of MRC1 with sCOMP levels was found likely to act independent of osteoarthritis subtypes. PMID: 25057126
  19. CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases PMID: 25614715
  20. TAMs phenotypes of glioma samples are the potential biomarkers in assessing the degree of malignancy, tumor invasion, and patient prognosis in clinic. PMID: 25182001
  21. Increased expression of CD206 was found in perivascular macrophages from HIV-infected brain. PMID: 25146376
  22. MRC-1 SNP, rs691005 was found to be associated with sustained viral response in HCV-1-infected patients; identified an interaction between MRC-1 rs691005 and IL-28B rs8099917 and response PMID: 24969847
  23. presence of soluble form of MR in human serum in critical illness PMID: 24114918
  24. There was a significant negative correlation between the number of CD163(+), CD204(+) or CD206(+) alveolar macrophages. PMID: 24498098
  25. The MRC1/CD68 ratio is positively associated with adipose tissue lipogenesis and with muscle mitochondrial gene expression in humans. PMID: 23951013
  26. Novel MRC1 gene polymorphisms are associated with susceptibility to pulmonary tuberculosis in Chinese Uygur and Kazak populations. PMID: 23653008
  27. confers responsivenes to CpG-motif containing oligodeoxynucleotides in macrophages PMID: 24184555
  28. Data suggest a role for CD206 in regulating allergen induced allergic responses in asthma. PMID: 23734186
  29. Report CD44/macrophage mannose receptor as a ligand/receptor pair involved in the process of lymphocyte transit via the lymphatic vasculature. PMID: 23603511
  30. The presence of human mannose receptor in a smaller number of vaginal epithelial cells of serodiscordant females prevented binding and HIV entry into these cells and therefore prevented sexual transmission of HIV. PMID: 23148569
  31. The molecular association of the macrophage mannose receptor (MR) with HSP70 family members via the receptor cytoplasmic tail may contribute to MR trafficking in macrophages. PMID: 23345393
  32. The mannose receptor found on the novel hybridoma cell has endocytic characteristics consistent with and similar to the mannose receptor found on the surface of monocyte-derived human macrophages. PMID: 22967244
  33. results failed to confirm the reported association between MRC1 variant rs1926736 and IFNG variant rs2430561 and leprosy in Han Chinese; however variants rs692527 and rs34856358 of the MRC1 gene were associated with paucibacillary leprosy and rs3138557 of the IFNG gene was significantly associated with multibacillary leprosy PMID: 22392581
  34. elderly subjects had twofold higher CD68 and CD206 gene expression (both P < 0.002) than young participants. In both studies, CD68(+) muscle macrophages were not associated with BMI PMID: 22314623
  35. The frequency of MRC1 allele G1186A (rs34039386)in a Chinese population was higher in the pulmonary tuberculosis group than controls. No association was found for G1195A, T1212C, C1221G, C1303T or C1323T. PMID: 22393309
  36. Sugar moieties on ADAMTS13 interact with MR, thereby promoting its endocytosis by antigen presenting cells. PMID: 22289891
  37. MMR distribution in liver, spleen, lung, kidney, heart, diaphragm, quadriceps, and triceps in these animal models and compared them with MMR distribution in wild-type mice. PMID: 21416197
  38. Studies show that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype. PMID: 21331365
  39. The studies provide the first demonstration of a significant role for mannose receptor, synergistic with TLR2, in activating a proinflammatory response to P. aeruginosa infection. PMID: 19197942
  40. These data suggest that in hepatitis B virus infected patients, mannose receptor-mediated interaction between HBsAg and dendritic cells and subsequent impairment of dendritic cells predominantly occurs at the main site of infection, the liver. PMID: 19683778
  41. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis. PMID: 21029423
  42. MR plays a key role in the T helper type (Th)2 cell polarization observed after dust mite glycoallergen Der p 1 exposure through regulation of indoleamine 2,3-dioxygenase activity. PMID: 20610655
  43. Data identify a new molecular pathway that links engagement of the mannose receptor, an important pattern recognition receptor for M. tuberculosis, with PPARgamma activation, which regulates the macrophage inflammatory response. PMID: 20554962
  44. The mannose receptor and hCG were colocalized on the surface of uterine natural killer cells. PMID: 19196802
  45. A significant association of exon 7 encoded amino acid haplotypes with leprosy per se (P = 0.012) and multibacillary leprosy (P = 0.004). PMID: 20035344
  46. Results suggest that sequence variations in the MRC1 gene are associated with the development of asthma in two independent and ethnically diverse populations. PMID: 19902202
  47. reduced expression in Mycobacterium tuberculosis-infected human macrophages exhibiting enhanced cellular adhesion PMID: 12368450
  48. Engagement of the endocytic C-type 1 mannose receptor elicits a secretory program in dendritic cells characterized by a repertoire of anti-inflammatory cytokines and chemokines and the ability to inhibit the generation of Th1-polarized immune responses. PMID: 14568928
  49. alveolar macrophage mannose receptor mediates Pneumocystis mediated NF-kB nuclear translocation and may represent an important mechanism of the host cell response to Pneumocystis infection PMID: 15155616
  50. Endocytosis of glycosylated protein by the mannose receptor does not enhance presentation of antigen. The postulated role of the mannose receptor in presentation of glycoprotein-derived antigen is reevaluated in light of these results. PMID: 15190005
  51. MR is a binding receptor, which requires a partner to trigger phagocytosis in some specialized cells such as macrophages. PMID: 15767290
  52. The mannose receptors on human AM may suppress select proinflammatory cytokine release and may serve to regulate the innate inflammatory responses to infectious challenge in the lungs. PMID: 16000387
  53. Engagement of the Mannose Receptor by mannose-capped lipoarabinomannan during the phagocytic process directs Mycobacterium tuberculosis to its initial phagosomal niche, thereby enhancing survival in human macrophages. PMID: 16203868
  54. Pc-mediated IL-8 release by human AM requires the coexpression of MR and TLR2 and further supports the concept that combinatorial interactions of macrophage innate receptors provide specificity of host defense cell responses to infectious challenge. PMID: 17020928
  55. Mannose receptor (MR) may serve as a binding and an entry site, but the MR-mediated pathway does not lead to productive HIV-1 infection. PMID: 17360361
  56. demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII PMID: 17502612
  57. RAGE could also behave as a receptor for Mycobacterium tuberculosis PMID: 18279703
  58. The expressions of CD105, DC-SIGN and MMR were the strongest in decidua basalis of mid pregnancy and indicate the importance of decidual macrophages in tissue homeostasis at the uteroplacental interface. PMID: 18353434
  59. macrophage mannose receptor oligomerization enhances gp120-mediated binding of HIV-1 PMID: 19224860
  60. Expansion of small sputum macrophages in cystic fibrosis shows a failure to express MARCO and CD206. PMID: 19403625
  61. Data show that macrophages cocultured with MSCs consistently showed high-level expression of CD206, a marker of alternatively activated macrophages. PMID: 19772890

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Subcellular Location Endosome membrane, Single-pass type I membrane protein, Cell membrane, Single-pass type I membrane protein
Database Links

HGNC: 7228

OMIM: 153618

KEGG: hsa:4360

STRING: 9606.ENSP00000239761

UniGene: Hs.743903

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