MRC1 Research Reagents

Mannose receptor 1 (MCR1), also known as CD206, is a transmembrane protein with a relative molecular mass of 166 kDa. It is a marker of M2 macrophages with high specificity. MCR1 is mainly distributed on the surface of most macrophages and immature dendritic cells, and acts as a pattern recognition receptor to recognize glycoproteins and glycolipids on the surface of pathogens, so it plays a role in antigen recognition and antigen presentation. In addition, MCR1 also plays a role in the clearance of sulfated glycoprotein hormones and glycoproteins produced under pathological conditions in the systemic circulation. A soluble form of MCR1 is found in the periphery after proteolytic cleavage of the macrophage membrane. The soluble form of MCR1, similar to the membrane form, also recognizes sulfated and mannosylated carbohydrates and can alter innate and adaptive immune responses.
Research shows that tumor-associated macrophages participate in the tumor microenvironment and can promote the formation and metastasis of various tumors. M2-type tumor-associated macrophages are the majority, which are found in breast cancer, ovarian cancer, pancreatic cancer and prostate cancer. Traces of it can be found. As a marker of M2 macrophages, MCR1 is highly specific and can be used as a potential marker for the diagnosis of malignant tumors.

The following MRC1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MRC1 Antibodies

MRC1 Antibodies for Homo sapiens (Human)

MRC1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

MRC1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

MRC1 Proteins

MRC1 Proteins for Homo sapiens (Human)

MRC1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

MRC1 Proteins for Mus musculus (Mouse)

MRC1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)


MRC1 ELISA Kit for Mus musculus (Mouse)

MRC1 ELISA Kit for Homo sapiens (Human)

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