Recombinant Human Mixed lineage kinase domain-like protein(MLKL)

In Stock
Code CSB-EP850851HUa0
Product Type Recombinant Protein
Size US$2466Purchase it in Cusabio online store
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Uniprot No. Q8NB16
Lead Time 3-7 business days
Relevance Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity Greater than 85% as determined by SDS-PAGE.
Sequence MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYLPPKCMQEIPQEQIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
Research Area Signal Transduction
Source E.coli
Gene Names MLKL
Expression Region 1-471aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 58.5 kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Subcellular Location Cytoplasm, Cell membrane
Protein Families Protein kinase superfamily
Database Links

HGNC: 26617

OMIM: 615153

KEGG: hsa:197259

STRING: 9606.ENSP00000308351

UniGene: Hs.119878

Pathway TNF signaling pathway
Necroptosis

Q&A and Customer Reviews

Q&A
Q:

Could you please let me know the concentration and volume for CSB-EP850851HUa0-50ug?

A:
Very nice to receive your inquiry. CSB-EP850851HUa0-50ug N-terminal 6xHis-tagge
Buffer: 10 mM Tris-HCl, 1 mM EDTA, pH 8.0, 50% glycerol Concentration: 0.5mg/ml Volume: 100ul
Customer Reviews

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