MLKL

MLKL (mixed lineage kinase domain-like) is a protein associated with cell death processes. Its activation involves phosphorylation of its N-terminal domain, inducing a conformational change in MLKL, leading it to translocate to the cell membrane and trigger cell death. It notably operates in programmed necrotic cell death (necroptosis). Upon specific signaling stimuli, MLKL promotes programmed necroptotic cell death, a process linked to biological events like immune responses, inflammation, and tissue repair. In the realm of disease therapeutics, extensive attention is given to the phosphorylation status and activity of MLKL. Research on MLKL is critical for understanding the molecular mechanisms of necrotic cell death, particularly its role in immune-related and inflammatory diseases, and for exploring potential therapeutic strategies.

Popular Product

Recombinant Human Mixed lineage kinase domain-like protein (MLKL)

Validated Data

SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.