MLKL Antibody

Datasheet
Code CSB-PA003250
Size US$167
Uniprot No. Q8NB16
Image
  • Western Blot analysis of K562 cells using MLKL Polyclonal Antibody
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from the N-terminal region of Human MLKL.
Raised in Rabbit
Species Reactivity Human
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias MLKL; Mixed lineage kinase domain-like protein
Immunogen Species Homo sapiens (Human)
Target Names MLKL
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Subcellular Location Cytoplasm, Cell membrane
Protein Families Protein kinase superfamily
Database Links

HGNC: 26617

OMIM: 615153

KEGG: hsa:197259

STRING: 9606.ENSP00000308351

UniGene: Hs.119878

Pathway TNF signaling pathway
Necroptosis

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