Recombinant Human Ras-related protein Rap-1A (RAP1A)

1. HL-60 neutrophil-like cells expressing Rap1a(G12V) or Radil have an elongated phenotype because of enhanced uropod adhesion as they attempt to migrate on fibronectin. This elongated phenotype driven by Rap1a(G12V) or Radil is reversed by Galphai1(Q204L), but not by WT Galphai1 expression, suggesting that Galphai-GTP also regulates adhesion in immune cells at the level of, or downstream of, Radil. PMID: 29259127
2. Study identifies Epac2-Rap1 signaling as a novel feedback mechanism in the heart, which controls mitochondrial reactive oxygen species production. PMID: 27649969
3. Data show that the Epac-Rap1 signaling axis is involved in triapine resistance. PMID: 27602951
4. Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL. PMID: 29127148
5. These findings provide the first evidence linking Rap1A with ovarian cancer development through the ERK/p38 and Notch signaling pathways, indicating that Rap1A may be used as a novel diagnostic marker or a therapeutic target for ovarian cancer. PMID: 27925454
6. High RAP1 expression is associated with neuroblastoma. PMID: 28456710
7. Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated. PMID: 27199371
8. Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction PMID: 27235135
9. Unlike Rap1B, phosphorylation in the polybasic region of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS-607. PMID: 27760305
10. SHANK1 and SHANK3 act as integrin activation inhibitors by sequestering active Rap1 and R-Ras via the SPN domain and thus limiting their bioavailability at the plasma membrane. PMID: 28263956
11. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding. PMID: 28003362
12. These data suggested that HBV-infection could up-regulate the expression of miR-203a, thus down regulated the expression of Rap1a. PMID: 27780730
13. Studies indicate that Rap interacting proteins decide the subcellular localization of Rap, and the interaction modes with downstream Rap effectors. PMID: 27322838
14. These findings provide further evidence that a crucial role for miR-203 in inhibiting metastasis of PCa through the suppression of Rap1A expression. PMID: 25636908
15. Our findings suggest that RAP1 may be a useful biomarker for the diagnosis of ical intraepithelial neoplasia . PMID: 25856570
16. RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome. PMID: 26280580
17. Rap1 knockdown attenuates prostacyclin (PC)-induced vascular endothelial cell (EC) monolayer recovery. PMID: 25545047
18. Data indicate that through GTPase-activating proteins ArhGAP29 complex formation Rap1 GTP-binding protein spatially restricts Rho-mediated signaling, which is necessary for endothelial barrier potentiation. PMID: 25963656
19. The direct interaction between Zscan4 and Rap1 may explain how Zscan4 rapidly increases telomere length, yielding important information about the role of these proteins in telomere biology. PMID: 24840609
20. Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. PMID: 25533468
21. crystal structure of an active, GTP-bound GTPase domain of Rap1 in complex with the Ras association (RA)-pleckstrin homology (PH) structural module of RIAM at 1.65 A, is reported. PMID: 24287201
22. a model by which the small GTPase Rap1 could regulate aES assembly/remodelling. PMID: 24719879
23. basal levels of Rap1 activity holds up cell adhesion, whereas sequential regulation of C3G and GAP by IGF-IR reverses the labile Rap1 function from supporting adhesion to promoting migration. PMID: 25028810
24. a Rap1A/beta1 integrin pathway, activated downstream of G-protein-coupled receptor stimulation and RhoA, in glioblastoma cell proliferation. PMID: 24790104
25. optimal cell migration is associated with cycles of Rap1 activation, membrane egress, and inactivation, and requires the regulated phosphorylation of Rap1 by PKA PMID: 23946483
26. these studies extend of alpha2C-ARs is mediated through Rap1-filamin signaling. Perturbation of this signaling pathway may lead to alterations in alpha2C-AR trafficking and physiological function. PMID: 23864608
27. These data show that HEG1 can recruit the Rap1-KRIT complex to the plasma membrane. PMID: 23814056
28. Data indicate that Epac1-Rap1A-RhoA-ROCK signaling affects Cl- secretion via effects on the apical expression of KCNN4c channels. PMID: 23720748
29. endothelial barrier resistance is determined by the combined antagonistic actions of Rap1 and Rap2 PMID: 23469100
30. High Rap1A expression is associated with invasive breast tumors. PMID: 23405264
31. the Aurora-A/Rap-1A pathway is associated with survival, tumor progression, and metastasis of oral cavity squamous cell carcinoma patients. PMID: 23219753
32. Syndecan-1 restrains migration in lung epithelium by activating Rap1 to slow focal adhesion disassembly. PMID: 22899717
33. Studies indicate that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation. +++ ERROR +++ studies establish that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation. PMID: 23097489
34. Constitutive Rap1 activation in human prostate tumor cells promotes hypoxic induction of VEGF and angiogenesis, and PKA antagonizes this effect. PMID: 23166790
35. This article discusses the role of RAP1 and Rap1GAP in squamous cell carcinoma of the head and neck progression in the context of a microRNA-oncogene-tumor suppressor gene axis. PMID: 22684501
36. the PI3 kinase/Rap1 pathway is intrinsically impaired in platelets from JAK2V617F-positive essential thrombocythemia patients, resulting in diminished thrombin and thrombopoietin-mediated integrin alpha(IIb)beta(3) activation PMID: 23243278
37. It was shown that the kinesin KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules. PMID: 23209302
38. High RAP1A expression is associated with esophageal squamous cell carcinoma. PMID: 22859270
39. The identification of a miR-337-3p as a modulator of cellular response to taxanes, and STAT3 and RAP1A as regulatory targets which mediate that response. PMID: 22723956
40. Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. PMID: 22810897
41. Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1) PMID: 22577140
42. cAMP induces a conformational change in Epac1 that enables DEP domain-mediated binding to phosphatidic acid, resulting in the tethering of Epac1 at the plasma membrane and subsequent activation of Rap PMID: 22343288
43. farnesylthiosalicylic acid-amide inhibits contact sensitivity through Rap1 inhibition PMID: 21716322
44. Epac1 is expressed in human neutrophils and is involved in cAMP-dependent regulation of Rap1. However, the loading of GTP on Rap1 per se is not sufficient to promote activation of beta2 integrins. PMID: 21750123
45. These results demonstrate a distinct physiological role for Ser(756) of beta2 integrin, in conjunction with the actions of talin and Rap1, during alphaMbeta2 activation in macrophages. PMID: 21605078
46. For the first time, a role has been shown for Rap1-mediated association between adherens junction and tight junction complexes in the 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-induced pulmonary vascular endothelial cell barrier protection. PMID: 21520057
47. Rap1A binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A PMID: 21468893
48. cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity PMID: 21454546
49. PA and Rap1 cooperatively regulate RA-RhoGAP activity for promoting neurite outgrowth. PMID: 21169361
50. Results indicate that guanine nucleotide exchange and interactions with SmgGDS splice variants can regulate the entrance and passage of PBR-possessing small GTPases through the prenylation pathway. PMID: 20709748

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HGNC: 9855

OMIM: 179520

KEGG: hsa:5906

STRING: 9606.ENSP00000348786

UniGene: Hs.190334