Recombinant Mouse Calcitonin receptor(Calcr),partial

Code CSB-YP004439MO1
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Source Yeast
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Code CSB-EP004439MO1
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Source E.coli
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Code CSB-EP004439MO1-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004439MO1
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Source Baculovirus
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Code CSB-MP004439MO1
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Calcr; Calcitonin receptor; CT-R
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.
Gene References into Functions
  1. Endosomal signaling of the CLR mediates pain transmission. PMID: 29087309
  2. calcitonin receptor is expressed in the suprachiasmatic nucleus and mediates body temperature fluctuations during the active phase in mice. PMID: 29440246
  3. Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC niche. PMID: 26440893
  4. data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies. PMID: 26044139
  5. upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta PMID: 26400621
  6. protects the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis PMID: 26135836
  7. Together, these data indicate that signaling through RAMP1 and CLR plays a role in mediating asthma pathology PMID: 25010197
  8. The relevance of the OPG/RANK/RANKL system in the particle-induced osteolysis process, was investigated. PMID: 25486133
  9. Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner PMID: 23226525
  10. Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration. PMID: 22562803
  11. The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons PMID: 22271140
  12. CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling. PMID: 22315449
  13. CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts. PMID: 20850575
  14. Data show that amylin inactivation leads to a low bone mass due to an increase in bone resorption, whereas bone formation is unaffected. PMID: 14970190
  15. Calcr is imprinted in a tissue-specific manner, with a predominant expression from the maternal allele in the brain PMID: 12730726
  16. Data show that mutation of calcitonin-like receptor did not affect its expression at the cell surface, but impaired the calcitonin gene-related peptide and adrenomedullin receptor function in the presence of receptor-activity-modifying proteins 1 and 2. PMID: 15194494
  17. CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins PMID: 18384073
  18. These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress. PMID: 18627265

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 2 family
Database Links
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