Recombinant Mouse Eukaryotic translation initiation factor 4E-binding protein 1 (Eif4ebp1)

1. 4E-BP proteins may prevent excess lipid accumulation in skeletal muscle and suggest that 4E-BPs are key regulators of muscle homeostasis regardless of insulin sensitivity. PMID: 28544394
2. decreasing cap-dependent translation by expressing a constitutively active mutant of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents neuronal misplacement and soma enlargement, while partially rescuing dendritic hypertrophy induced by hyperactive mTORC1. PMID: 27647922
3. we show that simultaneous inhibition of mTOR signaling to both S6K1 and 4E-BP1 is sufficient to reduce AKT-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin PMID: 27705797
4. 4E-BP1 is a gender-specific suppressor of obesity that regulates insulin sensitivity and energy metabolism. PMID: 27498874
5. The authors now show that West Nile virus growth and protein expression are dependent on mTORC1 mediated-regulation of the eukaryotic translation initiation factor 4E-binding protein/eukaryotic translation initiation factor 4E-binding protein (4EBP/eIF4E) interaction and eukaryotic initiation factor 4F (eIF4F) complex formation to support viral growth and viral protein expression. PMID: 27763553
6. p-mTOR, p-4EBP1, HIF-1alpha and VEGF together are involved in the pathogenesis of asthma. PMID: 28100332
7. Thus, translational control by 4E-BP1 downstream of mTOR effects the expression of neuroligin 1 and excitatory synaptic transmission in the spinal cord, and thereby contributes to enhanced mechanical nociception. PMID: 26678009
8. The findings support a model whereby elevated 4E-BP1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of 4E-BP1 within its PEST motif. PMID: 26998719
9. The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration. PMID: 25382660
10. Oxidative stress-induced premature senescence occurred due to impaired autophagy function through 4EBP1 phosphorylation. PMID: 25682865
11. Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production. PMID: 25872869
12. These findings indicate that regulation of 4E-BP1 in skeletal muscle may serve as an important conduit through which mTORC1 controls metabolism. PMID: 26121750
13. Disruption of genes encoding Eif4ebp1 and Eif4ebp2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice. PMID: 24945486
14. mTORC1 also regulates HIF-1alpha synthesis on a translational level via co-operative regulation of both initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase-1 (S6K1) PMID: 24931163
15. Translational repression of TOP mRNAs involves TSC and Rheb and hypophosphorylated state of 4E-BP. PMID: 24627160
16. Overexpression of eIF4E, the proto-oncogene whose activity is specifically inhibited by 4EBP1, resulted in hepatocellular carcinoma development in cooperation with activated Ras. PMID: 25145583
17. 4E-BP1 is a trigger for parthenolide -induced autophagy PMID: 25482447
18. The 4E-BP1 may suppress brown adipocyte differentiation and PGC-1alpha expression in white adipose tissues. PMID: 23672244
19. also seen in mitotic cells, indicating that EIF4EBP1 control of localized mRNA translation is likely key to correct segregation of genetic material across cell types. PMID: 23852387
20. Loss of PINK1 impairs both hypoxia-induced 4E-BP1 dephosphorylation and increase in the ratio of internal ribosomal entry site dependent to cap-dependent translation PMID: 24553947
21. The results of this study revealed a key role for mTOR/4E-BP1-mediated translational control in regulating entrainment and synchrony of the master clock. PMID: 23972597
22. these data provide evidence for a novel mechanism whereby O-GlcNAcylation of 4E-BP1 mediates translational control of hepatic gene expression. PMID: 23434932
23. PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1 PMID: 23049865
24. Elevated levels of 4E-BP1 may be involved in a mechanism to arrest brain development in Phgdh knock out embryos. PMID: 23350942
25. A potential interaction of LRRK2 and 4E-BP1 in mammalian cells and brain, is investigated. PMID: 23082216
26. in the absence of 4E-BP proteins, mTORC1-mediated phosphorylation of p70S6K1 is elevated by a reduction in competition between the two substrates for interaction with raptor PMID: 23184952
27. Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. PMID: 21840999
28. the inhibitory activity of 4E-BP1 is a key mediator of the negative effects of reduced mechanistic target of rapamycin signaling on cardiomyocyte homeostasis and heart function. PMID: 20644257
29. 4E-BPs had no effect on cell size, but they inhibited cell proliferation by selectively inhibiting the translation of messenger RNAs that encode proliferation-promoting proteins and proteins involved in cell cycle progression PMID: 20508131
30. Map4k4 negatively regulates PPARgamma post-transcriptionally, by attenuating mTOR signaling and a 4E-BP1-dependent mechanism PMID: 20038583
31. These results, together with the fact that 4E-BPs are markedly induced during granulo-monocytic differentiation of myeloid cells in vitro, highlight the pivotal role of 4E-BP1 and 4E-BP2 in the early phases of myelopoiesis PMID: 19175792
32. 4EBP1 is activated by the Type I IFN receptor-activated PI 3'-kinase pathway and has a role in regulating mRNA translation and induction of Type I IFN responses PMID: 12759354
33. eIF4E is rate-limiting for cell cycle progression before it regulates cell growth PMID: 14607835
34. eukaryotic initiation factor 4E-binding protein 1 gene transcription is regulated by polyamines PMID: 15351722
35. Comparison of the p53-induced patterns of eIF4GI and 4E-BP1 dephosphorylation and cleavage with those caused by the mTOR inhibitor rapamycin indicates that p53 activation and rapamycin have distinct but additive effects PMID: 15897901
36. formation of the Nrf-2/PMF-1 complex is involved in transcriptional regulation of 4E-BP1 PMID: 16647090
37. These findings suggest that the ability of cells to rephosphorylate 4E-BP1, resynthesise eIF4GI and restore the rate of protein synthesis after inactivation of p53 is an important aspect of recovery following the relief of physiological stress. PMID: 16990847
38. Increased insulin resistance in 4E-BP1 and 4E-BP2 double KO was associated with increased ribosomal protein S6 kinase (S6K) activity and impairment of Akt signaling in muscle, liver, and adipose tissue. PMID: 17273556
39. All-trans-retinoic acid- or cis-RA-dependent p21(Waf1/Cip1) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on transcriptional regulation of the p21(Waf1/Cip1) gene. PMID: 18280804
40. Pretreatment with cyanamide partially prevented the ethanol-induced lowering of 4EBP1 phosphorylation. PMID: 18317950
41. endocrine hormone insulin contributes to VEGF release in skin wounds through an Akt1-and 4E-BP1- mediated posttranscriptional mechanism in keratinocytes PMID: 18668138
42. Results show that overexpression of polycystin-1 in renal epithelial cells inhibits cell growth in a cell cycle-independent manner due to the downregulation of mTOR, S6K1, and 4EBP1, and through phosphorylation of tuberin. PMID: 19255143
43. These results indicate that mTOR downstream effector 4EBP1 is essential for normal thymocyte proliferation, but deregulation of 4EBP1 in Atm deficiency is a major factor driving thymic lymphomagenesis in the animals. PMID: 19364503
44. High-density lipoproteins can protect beta-cells through modulation of 4E-BP1 depending on the type of stress stimuli. PMID: 19574449
45. Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma. PMID: 19603014

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KEGG: mmu:13685

STRING: 10090.ENSMUSP00000033880

UniGene: Mm.6700