Recombinant Mouse High affinity nerve growth factor receptor (Ntrk1), partial

1. intrachromosomal deletion generating a fusion between BCAN and NTRK1 drives the formation of aggressive high-grade gliomas and confers sensitivity to entrectinib PMID: 28695888
2. System xC(-)-mediated TrkA activation therefore presents a promising target for therapeutic intervention in cancer pain treatment. PMID: 29761734
3. these findings demonstrate that communication between osteoblasts and sensory nerves through NGF-TrkA signaling is essential for load-induced bone formation in mice. PMID: 28416686
4. Imipramine protected bupivacaine-induced neurotoxicity in DRG, likely via the co-activation of TrkA and TrkB signaling pathways. PMID: 28398601
5. Foretinib protected neurons by suppressing both known degenerative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the proapoptotic BH3 family members. PMID: 28877995
6. retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons. PMID: 28919207
7. These findings suggest that by interacting with PlexA4, TrkA plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 localization and patterning. PMID: 26945060
8. proposal that KIF1A is essential for the survival and function of sensory neurons because of the TrkA transport and its synergistic support of the NGF/TrkA/PI3K signaling pathway PMID: 27263974
9. As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation PMID: 27655914
10. TrkA misfolding and aggregation induced by some Insensitivity to Pain with Anhidrosis mutations disrupt the autophagy homeostasis causing neurodegeneration. PMID: 27551041
11. Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction. PMID: 26642930
12. Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA receptor (TrkA) through lysophosphatidic acid receptor 1 (LPA1) binding to TrkA PMID: 26597701
13. adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk mouse mutant with a pain phenotype PMID: 24516396
14. SOCS2 immunoprecipitates with TrkA and a juxtamembrane motif of TrkA is required for this interaction. Over-expression of SOCS2 in PC12 Tet-On cells increased total and surface TrkA expression. PMID: 24484474
15. the ubiquitination of the TrkA neurotrophin receptor plays a critical role in NGF-mediated functions, such as neuronal survival and sensitivity to pain. PMID: 24760869
16. These data suggest that ubiquitination is a mechanism used in nociceptive neurons to regulate TrkA level and function. PMID: 24623787
17. NGF support the survival of only a subset of basal forebrain cholinergic neuron during brain development. PMID: 23100411
18. Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex. PMID: 22847002
19. Down-modulation of STK25, but not STK24, rescued medulloblastoma cells from NGF-induced TrkA-dependent cell death, suggesting that STK25 is part of the death-signaling pathway initiated by TrkA and CCM2. PMID: 22782892
20. findings suggest the implication of Trk A and Src in ERbeta mediated brain functions and related disorders during aging PMID: 22011838
21. This study demonistrated that demonstrated that TrkA loss results in cholinergic BF dysfunction and cognitive decline. PMID: 22442072
22. Cux2 is expressed and may participate in development of a specific subtype of myelinated TrkA(+) nociceptors. PMID: 21945863
23. Both NTRK1 and NTRK2 receptors are necessary for the timely assembly of primordial follicles and for sustaining early follicular development. PMID: 19357131
24. PxIxIT-containing dynamin1 isoforms colocalize with surface TrkA receptors, and their phosphoregulation is selectively required for NGF-dependent TrkA internalization and axon growth in sympathetic neurons. PMID: 21689596
25. mouse NK cells express the NGF receptor TrkA and this expression is dynamically regulated PMID: 21152021
26. the earlier that the blockade of TrkA occurs, the more effective the control of cancer pain and the tumor-induced remodeling of sensory nerve fibers PMID: 21138586
27. Neuroprotective effect of low-molecular peptide mimetic (GK-2) of nerve growth factor is related to activated synthesis of heat shock proteins (hsp32 and hsp70) and increased phosphorylation of TrkA receptor PMID: 21395008
28. overexpressed on the bronchoalveolar lavage fluid cells of asthmatic mice PMID: 20934630
29. STAT3 has a role in in vitro transformation triggered by TRK oncogenes PMID: 20209132
30. TrkA and TrkC instruct developing neurons to die, both in vitro and in vivo. By contrast, TrkB, a closely related receptor primarily expressed in the central nervous system, does not. PMID: 20811452
31. Data show that down-regulation of TrkA also occurs in the cerebellum of SCA17 transgenic mice prior to Purkinje cell degeneration. PMID: 19643914
32. Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors PMID: 11750876
33. ShcB and ShcC bind the Trk receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain PMID: 12006576
34. both trkA and trkC neurotropin receptors influence germ cell numbers during testis development and events such as seminiferous cord formation PMID: 12021070
35. role in developing Merkel innervation PMID: 12117822
36. trkA detected in lung homogenate, and in capillary cells, but not in alveolar macrophages; a previously unknown trafficking signal occurs through neurotrophins in peripheral lung PMID: 12122447
37. TrkA is activated by gangliosides inducing the release of neurotrophins, but less potently than TrkC PMID: 12388556
38. Trk A was not observed in stria vascularis, hair cell stereocilia, nor in the Trk B- and Trk C-rich cerebellum. This distribution pattern of Trk A suggests that its ligand, NGF, exerts significant trophic effects in the rodent inner ear. PMID: 14698082
39. Stress and substance P injection significantly increased the abortion rate and up-regulated decidual NGF and TrkA expression compared with the control PMID: 14725570
40. Related neurotrophins NGF and NT-3, acting through a common receptor, TrkA, are required for sequential stages of sympathetic axon growth and, thus, innervation of target fields. PMID: 15260993
41. lack of this protein provokes an altered organogenesis of the thymus. PMID: 15372954
42. mutants appear normal, have elevated serum levels of certain immunoglobulin classes and accumulate B1 cells with aging PMID: 15459109
43. mRNA-TrkA is over-expressed in the subventricular zone and hippocampus of dominant and subordinate mice. PMID: 15639186
44. Data demonstrate that Kalirin binds to and colocalizes with the TrkA neurotrophin receptor in neurons. PMID: 15923627
45. Klf7 gene ablation reduces TrkA expression in sensory neurons due to effect on cell death PMID: 15937222
46. identify Src family kinases as mediating nucleotide-enhanced neurotrophin-dependent neuronal differentiation and thus, as a key convergence point for interaction between TrkA receptor tyrosine kinases and P2Y(2) G-protein-coupled receptors PMID: 16842754
47. Cooperation between Brn3a and Klf7 is required for endogenous TrkA gene expression and the survival of nociceptive sensory neurons. PMID: 17011544
48. Results suggest that DeltaNp73 negatively regulates NGF-mediated neuronal differentiation by transrepressing TrkA. PMID: 17353261
49. deltaTrkA has potent and unique transforming properties in leukemogenesis PMID: 17673903
50. Semaphorin3A regulates axon growth independently of growth cone repulsion via modulation of TrkA signaling. PMID: 18096366

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KEGG: mmu:18211

STRING: 10090.ENSMUSP00000029712

UniGene: Mm.80682