Recombinant Mouse Homeobox protein NANOG (Nanog)

1. myoblasts that were primed by NANOG maintained their differentiation capacity for 20days after NANOG withdrawal PMID: 29245050
2. USP21 interacts with, deubiquitinates and stabilizes Nanog, and therefore maintains the protein level of Nanog in mouse embryonic stem cells to maintain stemness. PMID: 27886188
3. the epigenetic status of Oct4 and Nanog genes confirm that pre-induced pluripotent stem cells belong to an RVTg+OCT4+NANOG- state PMID: 27622636
4. In mouse embryonic stem cells, Cops2 binds to Nanog protein and prevent the degradation of Nanog by the proteasome. PMID: 27226076
5. Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog, Oct4, and Sox2. PMID: 28436127
6. Loss of phosphorylation enhances NANOG activity in reprogramming. Mutation S65A alone has the most significant impact on increasing NANOG reprogramming capacity. PMID: 28457890
7. Nanog, Oct4 and Tet1 interplay in establishing stem cell pluripotency has been described. PMID: 27146218
8. Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome. PMID: 28199843
9. Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains PMID: 28961274
10. Otx2-mediated Nanog regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development. PMID: 27292645
11. Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4, Sox2, and Nanog; Trim24 significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency. PMID: 27773674
12. studies highlight a new hypoxia-induced pathway in which NANOG activates BNIP3L expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL PMID: 28093523
13. Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells. PMID: 28636920
14. Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 heterodimerization and self-renewal activity. PMID: 27939294
15. In mouse model of acute uterine injury, Nanog homebox (NANOG) expression reached a peak at 6 h, while sex-determining region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) peaked later at 12 h after lipopolysaccharide (LPS) treatment. PMID: 28253866
16. NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells. PMID: 27125671
17. Data indicate that Nanog homeobox protein is important for the effects of reprogramming media. PMID: 26975336
18. Nanog enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 gene. PMID: 26795560
19. The different embryonic stem cells Nanog-expressing populations differ in their differentiation propensities. Nanog upregulation is not well correlated to Oct4, Sox2 and Klf4 expression, or cell cycle phase. PMID: 26760119
20. 1After the 32-cell stage, when embryos form the blastocyst cavity, Nanog expression was upregulated mainly in ICM cells while it was repressed in the future primitive endoderm lineage in an FGF signaling-dependent manner in the later stages PMID: 26660234
21. Nanog is able to transform normal somatic cells into tumor cells. PMID: 26733157
22. NANOG represses mitochondrial oxidative phosphorylation genes, as well as reactive oxygen species generation, and activates fatty acid oxidation to support tumor initiating cell self-renewal and drug resistance. PMID: 26724859
23. The cellular reprogramming-promoting function of mitoflashes occurs via the upregulation of Nanog expression. PMID: 26549484
24. the existence of three stable steady states for Nanog levels, which are the same in all the different conditions of the cell-culture medium. PMID: 23054952
25. NANOG binds to GLI1 and GLI3 proteins and represses Hedgehog-mediated transcription. PMID: 26797124
26. Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells. PMID: 26411691
27. TLR4 signaling via NANOG cooperates with STAT3 to activate Twist1 and promote formation of tumor-initiating stem-like cells in livers of mice. PMID: 26582088
28. Pluripotency transcription factors Nanog and Oct4 positively modulate Sod2 gene transcription in induced pluripotent stem cells. PMID: 26642061
29. NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers PMID: 26751055
30. Forced expression of Nanog (and Esrrb) resulted in the dispensability of nucleostemin expression in embryonic stem cells. PMID: 25522312
31. Dax1 and Nanog have roles in stabilizing mouse embryonic stem cells and induced pluripotency PMID: 25284313
32. Data position Cited2 within the pluripotency gene regulatory network by defining Nanog, Tbx3, and Klf4 as its direct targets and demonstrate that the defects caused by Cited2 depletion are, at least in part, rescued by Nanog constitutive expression. PMID: 25377420
33. immunoprecipitation. Our data provide new insights into the expanded regulatory circuitry that coordinates Nanog expression. PMID: 26296469
34. NANOG is selectively expressed in stratified epithelia, most notably in the oesophagus where the Nanog promoter is hypomethylated. PMID: 24979572
35. Stochastic promoter activation significantly affects the Nanog expression variability in mouse embryonic stem cells. PMID: 25410303
36. prolonged expression upon differentiation in METTL3-depleted embryonic stem cells PMID: 25456834
37. BRD4 associates with BRG1, a key regulator of embryonic stem cell self-renewal and pluripotency, in the Nanog regulatory regions to regulate Nanog expression. PMID: 25146928
38. Despite downregulation of tumor suppressors and increased proliferation, ectopic Nanog expression did not lead to tumor formation. PMID: 25173648
39. Nanog may be an important mediator of reprogramming, it is not required for establishing pluripotency in the mouse, even under standard conditions. PMID: 24527385
40. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter PMID: 25743411
41. Taken together, our results suggest that Nanog positively regulates Zfp57 expression in multiple types of cells. PMID: 25445595
42. observed cell cycle-regulation of Nanog expression, and not Oct4, reaching high levels prior to G1/S transition, finely mirroring Cyclin E1 fluctuations PMID: 24695638
43. Nuclear transfer alone affords no immediate transition from a somatic to an Oct4- and Nanog-positive gene expression pattern, unless DNA replication is also in place within the mouse ooplasm. PMID: 24836291
44. Nanog protein promotes pluripotency by inhibiting endodermal specification. PMID: 24681518
45. Nanog functions in conjunction with mesenchymal factors Snai1 and Snai2 in the transcriptional regulation of pluripotency-associated genes and miRNAs during the Nanog-driven reprogramming process. PMID: 25240402
46. This network was rearranged during differentiation and restored in induced pluripotent stem cells. A large fraction of Nanog-interacting loci were bound by Mediator or cohesin in pluripotent cells. PMID: 23665121
47. Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression. PMID: 23963652
48. Foxa1 recruited Grg3 to the Nanog promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3. PMID: 24803390
49. SHP-1 participated in regulation of Nanog expression. PMID: 24466030
50. Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast. PMID: 24929238

Show More

Hide All

KEGG: mmu:71950

STRING: 10090.ENSMUSP00000012540

UniGene: Mm.485537