Recombinant Mouse Neurogenic locus notch homolog protein 2 (Notch2), partial

1. that regulating Notch2 protein levels is particularly important during normal signaling during mouse lens development PMID: 30059908
2. The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage. PMID: 28707394
3. Notch2 physiologically regulates bone remodeling by inhibiting trabecular bone formation in the appendicular skeleton. PMID: 27102824
4. Notch2 was crucial in maintaining the integrity of the epithelial and smooth muscle layers of the distal conducting airways, and our data suggest that epithelial Notch signaling regulates multiple aspects of postnatal development in the distal lung and may represent a potential target for intervention in pulmonary diseases. PMID: 27364009
5. Authors confirmed that NOTCH2 is significantly over-expressed in EEA. In the most relevant endometrial adenocarcinoma cell model, Ishikawa H, altering miR-181c expression produces significant changes in NOTCH2 expression, consistent with direct targeting. PMID: 28969912
6. These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 pathway as observed in patients with HCS. PMID: 29149593
7. Hajdu-Cheney Syndrome is a devastating disease associated with a gain-of-NOTCH2 function resulting in diverse clinical manifestations PMID: 27241678
8. Study indicates that knockdown of Notch2 promotes in vivo growth of triple-negative breast cancer (TNBC) and proposes that Notch2 functions as a tumor growth suppressor in TNBC. PMID: 27097807
9. Human biliary atresia and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-induced experimental cholestasis in mice are associated with increased expression of Notch2. PMID: 28688656
10. The data showed that the overexpression of miR-18a-5p could downregulate Notch2 expression and subsequently suppress endothelial-mesenchymal transition and cardiac fibrosis. PMID: 28733035
11. Transgenic mice harboring Notch2 mutation analogous to that in patients with Hajdu-Cheney syndrome (HCS) are severely osteopenic because of enhanced bone resorption; this model has now been validated. Data from further studies in transgenic mice suggest that the HCS mutation in osteoblasts, but not in osteoclasts, causes osteopenia in this model. PMID: 28592489
12. this study shows that Notch2 activity is required for the maintenance of lung tissue-resident memory CD103+ T cells PMID: 27776108
13. In this study, authors use a smooth muscle-specific deletion of Notch2 together with a global Notch3 deletion to produce mice with combinations of mutant and wild-type Notch2/3 alleles in vascular smooth muscle cells PMID: 26453897
14. 6955C-->T mutation in the Notch2 locus leading to cancellous and cortical bone osteopenia. PMID: 26627824
15. Data (including data from studies in transgenic/knockout mice) suggest deletion of Notch1 in podocytes prevents diabetic nephropathy development and up-regulates Notch2 expression; overexpression of Notch2 does not promote diabetic nephropathy. PMID: 26293507
16. NOTCH2 inhibits PDGF-B-dependent proliferation and its expression is decreased by PDGF-B. PMID: 25957400
17. BTK synergizes with Notch2 to govern marginal zone B cells in non-obese diabetic mice. PMID: 26034172
18. Surface expression of NOTCH2 was seen in specified E11 AGM (CD45+VE-cadherin+) hematopoietic progenitors. NOTCH activation by Delta1 can increase long-term engrafting HSC numbers from these cells. PMID: 25866967
19. drives multiple myeloma associated osteoclast development and bone destruction PMID: 25257302
20. Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. PMID: 25446530
21. This study demonstrates important functions for Jagged1 and Notch2 in the resolution of germ cell syncytia and the coordination of somatic and germ cell growth within follicles of the mouse ovary. PMID: 24552588
22. Loss of Notch2 has little influence on early embryonic pituitary proliferation but is crucial for postnatal progenitor maintenance. PMID: 24673559
23. Propose a receptor-specific function for Notch2 in regulating Jag-1-induced p27(kip1) expression and growth arrest in vascular smooth muscle cells. PMID: 23965337
24. Lack of Notch-2 prevents biliary tubule formation, both in vivo and in vitro. PMID: 23500150
25. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. PMID: 23913046
26. In the postnatal retina, NOTCH2, as well as the Notch downstream genes, HES1 and SOX9, were detected in VSX2/Cyclin D1/SOX2-expressing cells in the postnatal retina, and in the mature retina NOTCH2 was most abundant in Muller glia PMID: 23277114
27. The N2 extracellular domain (NECD) increases Notch protein localization to the cell surface during kidney development and is cleaved more efficiently upon ligand binding. PMID: 23806616
28. Notch2 appears to be the main determinant not only of biliary commitment of embryonic hepatoblasts during development but also of biliary reprogramming of adult hepatocytes. PMID: 23315998
29. Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye. PMID: 23676271
30. Notch2 signaling in NSCs produces features of GSCs and induces astrocytic lineage entry, consistent with a possible role in astrocytoma formation. PMID: 22717580
31. Our data establish an oncogenic role for constitutive Notch2 signaling in liver cancer development PMID: 23175466
32. Pubertal Notch2+ lineages play a critical role in the formation of alveolar clusters. PMID: 23604318
33. demonstrates that Notch2-mediated signaling in the somatic-cell lineage of the mouse ovary regulates oocyte apoptosis non-cell autonomously, and is essential for regulating breakdown of germ-cell nests and formation of primordial follicles PMID: 23406467
34. Osteoclastogenesis is enhanced following binding of monoclonal antibody to Notch2. PMID: 22390640
35. expression of constitutively active Notch2 in the myocardium of transgenic mice resulted in hypertrabeculation, reduced compaction, and ventricular septum defects PMID: 22865640
36. results suggest that two different assemblies of Notch receptors coordinate the numbers and distribution of the major epithelial cell types in the conducting airway during lung organogenesis PMID: 23132245
37. In vitro analysis show that both Notch2 and Notch3 robustly activate smooth muscle differentiation genes, and Notch3, but not Notch2 is a target of Notch signaling PMID: 22615991
38. These data identify Fos as one of the target genes for Notch2 signaling that is crucial for marginal zone B development. PMID: 22293205
39. Notch2-mediated signaling regulates lens morphogenesis, apoptosis, cell cycle withdrawal, and secondary fiber cell differentiation. PMID: 22173065
40. Data from transgenic/knockout mice indicate that Notch2 signaling acts as a binary switch that drives, depending on the cellular background, either T-cell development or the generation of marginal zone B-cells. PMID: 21795747
41. Notch2 is a common differentiation signal for T cell-priming CD11b(+) DC subsets in the spleen and intestine. PMID: 22018469
42. Notch signaling is involved in follicular development by regulating granulosa cell proliferation. PMID: 21427220
43. Whereas fetal RORgammat(+) cells matured in the fetal liver environment, adult bone marrow-derived RORgammat(+) ILCs matured outside the bone marrow, in a Notch2-dependent manner PMID: 21909092
44. Notch-2 was identified as a novel target for beta-catenin-dependent Wnt signaling. PMID: 21437251
45. Notch2 has a role in assuring orderly repopulation by HSCs, MPPs, myeloid cells, and lymphoid cells during BM regeneration PMID: 21285514
46. Loss of Notch2 is associated with impaired eradication of Strongyloides venezuelensis. PMID: 20971948
47. Notch-2 up-regulation after neonatal ischemia is detrimental to neuronal survival. PMID: 20876509
48. Notch2 activation did not skew the cell fate toward the proximal nephron but resulted in severe kidney dysgenesis and depletion of Six2-positive progenitors. PMID: 20299358
49. ADAM10 regulates marginal zone b cell development by initationing notch2 signaling. PMID: 20156974
50. Notch2 plays an important role in development of the roof plate of the diencephalon and mesencephalon, and cellular rearrangement is involved in this process PMID: 12242712

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KEGG: mmu:18129

STRING: 10090.ENSMUSP00000078741

UniGene: Mm.485843