Recombinant Mouse SH2 domain-containing adapter protein B (Shb)

1. The absence of the src homology 2 domain-containing transforming protein B (Shb) gene exacerbates the disease in myeloid leukemia, whereas it alters the disease characteristics without affecting latency in B- and T-cell leukemia. PMID: 29792386
2. The observed aberrations in myeloid cell properties in Shb-deficient mice are likely consequences of an abnormal vascular compartment and are not responsible for reduced muscle blood flow PMID: 25561022
3. a unique combinatorial response of increased vascular permeability and reduced recruitment of cytotoxic CD8+ cells occurs as a consequence of Shb deficiency in B16F10 melanomas. PMID: 25885274
4. Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells. PMID: 25274988
5. Data suggest that absence of Src homology-2 protein Shb accelerates disease progression by exerting dual roles in BCR-ABL-induced leukemia: increased cell expansion due to elevated focal adhesion kinase (FAK) activity and neutrophilia in peripheral blood. PMID: 24952416
6. loss of Shb alters TCR signalling ability, thereby favouring the development of Th2-driven inflammation and exacerbating symptoms of allergy PMID: 24645804
7. Shb knockout mouse exhibited structural and functional (angiogenesis and vascular permeability) vascular abnormalities that have implications for understanding the function of VEGF-A under physiological conditions PMID: 22562363
8. Data show reduced VEGF-A expression in Shb-deficient tumors.Interference with Shb signaling may provide novel means for future cancer therapy. PMID: 22336752
9. Shb appears to play an important modulating role on T- Cell receptor signaling, thus regulating the peripheral CD4+ T(H)2 cell response. PMID: 21223549
10. It is concluded that SHB regulates normal oocyte and follicle development and that perturbation of SHB signaling causes defective meiosis I and early embryo development PMID: 20585392
11. Shb binds directly to FAK and regulates its phosphorylation leading to enhanced cell spreading in a Src-dependent manner. PMID: 12464388
12. The findings suggest that Shb may play a crucial role during early ES cell differentiation to vascular structures by transducing VEGFR-2 and PDGFR-beta signals. PMID: 15919073
13. SHB is required for appropriate hematopoietic and vascular differentiation PMID: 16971391
14. SHB has a role during reproduction and development PMID: 17676633
15. Shb regulates apoptosis and cell shape in tumor endothelial cells via focal adhesion kinase PMID: 17914455
16. Expression of R522K-Shb enhances certain signaling pathways downstream of FGF and that an interplay between FGF and activin A participates in ES cell differentiation to endoderm. PMID: 18093225
17. Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth. PMID: 19223532
18. It is concluded that islets deficient in the Shb protein are less susceptible to cytotoxic conditions, and that this partly depends on their increased ability to induce Hsp70 under such circumstances. PMID: 19615333
19. loss of Shb impairs insulin secretion, alters islet microvascular morphology, and increases the basal blood glucose concentration. PMID: 19696098

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KEGG: mmu:230126

STRING: 10090.ENSMUSP00000060433

UniGene: Mm.251716