The rabbit IgG recombinant CD74 monoclonal antibody specifically targets the human CD74. The DNA encoding the CD74 monoclonal antibody was inserted into the plasmid and subsequently transfected into the cell line for expression. The product was purified through the affinity-chromatography method to get the CD74 recombinant antibody. This CD74 antibody has been demonstrated to be highly specific and sensitive in ELISA, IHC, and FC applications.
CD74 plays an essential role in antigen presentation by mediating the assembly and subcellular trafficking of the MHCII complex. It also serves as a surface receptor for the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF), which regulates endosomal trafficking, cell migration, and cellular signaling independently of MHCII. CD74 is upregulated in several cancers and is linked to increased proliferation and metastatic potential.